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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by linkadge on July 28, 2007, at 15:51:59
According to the following study, the antihistamine hydroxyzine, sometimes used for sleep, is an inhibitor of MAO-B.
Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine.
[My paper] J O'Sullivan , M I O'Sullivan , K E Tipton , G Davey
The effects of the drug hydroxyzine on the activities of the rat liver monoamine oxidases (EC 1.4.3.6; MAO) and the membrane-bound and soluble forms of bovine semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) were studied. Hydroxyzine was found to be a competitive inhibitor of MAO-B (Ki - 38 microM), whereas it had a low potency towards MAO-A (IC50 > 630 microM). Although it was a relatively potent competitive inhibitor of bovine plasma SSAO (Ki approximately 1.5 microM), it was a weak inhibitor of the membrane-bound form of the enzyme from bovine lung (IC50 approximately 1 mM). These findings extend our knowledge of the drug binding capabilities of the amine oxidases and suggest that these interactions may contribute to the complex actions of this drug.
Linkadge
Posted by med_empowered on July 28, 2007, at 18:38:22
In reply to hydroxyzine is a MAO-B inhibitor, posted by linkadge on July 28, 2007, at 15:51:59
hydroxyzine is strange. It made me more anxious. It can block dopamine. It sometimes causes TD. Now its an MAOI?
Strange. Complicated drug...still, I think BZDs are better.
Posted by linkadge on July 28, 2007, at 19:46:12
In reply to weird, posted by med_empowered on July 28, 2007, at 18:38:22
Yeah, there are some strange binding affinities for certain drugs.
For instance, the drug cogentin actually has fairly high binding for DAT.
The euphoriant like effects, (sometimes attributed to its anticholinergic profile), may be a result of, at least in part, its ability to block the dopamine transporter, with moderate affniinty.
I personally thought cogentin was about as good as any antidepressant.
Linkadge
This is the end of the thread.
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