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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by KayeBaby on June 8, 2007, at 11:44:27
I am very interested in this angle.
I have sample packs of abilify, it is supposed to be helpful for motivation in low doses. I feel really great on the EMSAM and Namenda I just don't have the gumption to move much and I know part of this is from being used to taking stimulants. The other part is that lack of physical motivation has always been an issue with me. (NLD)I really wish I could get a little kick in the rear. I keep toying with the idea of Abilify and in researching today I found this study.
Would there be any real harm in trying the stuff? Could I trial it? Is there withdrawal sickness with Abilify.
I am still sleeping 10-12 hrs a night and this is with EMSAM.
Would love your thoughts on this.
Thanks!
Kaye
http://www.springerlink.com/content/fg2m766325r37p7j/
Received: 4 May 2006 Accepted: 16 July 2006 Published online: 5 September 2006Abstract
Rationale Withdrawal from repeated amphetamine administration has been shown to decrease the motivation to work for a natural reward in rats, a phenomenon thought to be associated with hypofunction of the mesolimbic dopamine system.
Objectives We tested whether aripiprazole, a partial dopamine receptor agonist, can restore the animals’ responding for reward pellets after amphetamine withdrawal.
Materials and methods Rats were trained to lever-press for food pellets under a progressive ratio-schedule of reinforcement. After reaching a stable breakpoint, i.e., the highest ratio completed, one group was injected ten times with increasing doses of amphetamine (1 to 10 mg/kg, three times a day for 4 days), while the other group received vehicle injections. The rats were again tested for their breakpoint 24 h after the last amphetamine injection under 0.0, 0.25, 0.75, and 2.5 mg/kg aripiprazole.
Results Withdrawal from repeated amphetamine injection reduced the breakpoint while low doses of aripiprazole (0.25 and 0.75 mg/kg) prevented this effect. In addition, the rats needed a longer time for the first 20 pellets (fixed ratio-schedule training before starting the progressive ratio-schedule) after amphetamine withdrawal but not after subsequent injection with aripiprazole. It is notable that the injection of 2.5 mg/kg aripiprazole reduced responding for reward pellets and prolonged the duration for the first 20 pellets irrespective of previous amphetamine or vehicle treatment. However, withdrawal from repeated administration of 0.25 and 2.5 mg/kg aripiprazole did not reduce responding for reward pellets.
Conclusions These results suggest that aripiprazole may have potential use as a treatment for the motivational effects of the acute withdrawal stage of the psychostimulant addiction cycle.
Posted by Zyprexa on June 8, 2007, at 12:05:25
In reply to Abilify for Amphetamine withdrawal??, posted by KayeBaby on June 8, 2007, at 11:44:27
I didn't sleep at all on Abilify, may be that kick in the but you need. I have wondered if it would work for this. I've never realy taken any amphetamines. Abilify has been the most activating and psycho-active med I've taken. I could not tolerate it though. Let me know if it works!
Article sounds convincing!
Zyprexa, for me!
Posted by KayeBaby on June 8, 2007, at 13:37:48
In reply to Re: Abilify - It's worth a try, posted by Zyprexa on June 8, 2007, at 12:05:25
Thanks fpor the information!
How many days till you started to feel the activation of abilify? What dose did you start at?
Did you have any other problems asid4e from the over-stimulation?
Appreciation,
Kaye
Posted by Zyprexa on June 8, 2007, at 14:40:12
In reply to Re: Abilify - It's worth a try, posted by KayeBaby on June 8, 2007, at 13:37:48
> Thanks fpor the information!
>
> How many days till you started to feel the activation of abilify? What dose did you start at?
>Day one.
> Did you have any other problems asid4e from the over-stimulation?
>Anxiety, paranoia.
> Appreciation,
> Kaye
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