![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by KayeBaby on February 17, 2007, at 15:49:57
I cannot even snap with my non-dominant hand. This is interesting to me.
Peace,
Kaye
Lateralization of hand skill in bipolar affective disorder
J. Savitz, L. van der Merwe, M. Solms and R. Ramesar
Abstract
Diverse strands of evidence suggest that schizophrenia is associated with an excess of left and mixed handedness, reflecting anomalous cerebral lateralization. Genetic studies have indicated a degree of overlap between bipolar disorder (BPD) and schizophrenia. Nevertheless, pattern of handedness and degree of lateralization have not been explicitly tested in BPD. We measured handedness, footedness and relative manual dexterity in a sample of 47 families comprising BPD probands and their bipolar-spectrum and unaffected relatives (N = 240). The BPD I sample (N = 55) was significantly more lateralized on handedness, footedness and relative manual dexterity than their unaffected relatives (N = 66). They were also more lateralized than their relatives with other psychiatric diagnoses. No evidence of excess mixed handedness or footedness was observed in the BPD I sample. We raise the possibility that schizophrenia and BPD I differ in that disproportionate left-hemisphere dominance in BPD I is associated with right-hemisphere dysfunction leading to deficits in emotional regulation. Given our results, we hypothesized that degree of lateralization may be a phenotypic marker or endophenotype for BPD I. We therefore conducted a family-based genetic association analysis with this quantitative trait. Relative hand skill was significantly associated with a functional variant in the catechol-O-methyltransferase gene. We speculate that this polymorphism may influence brain lateralization.
Source: Genes, Brain and Behavior
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1601-183X.2006.00299.x
Posted by linkadge on February 17, 2007, at 16:52:05
In reply to Lateralization of hand skills in Bipolar, posted by KayeBaby on February 17, 2007, at 15:49:57
Intereresting. I am left handed. I am very messey.
I have often wondered if my handedness is related to my issues.
Linakdge
Posted by Phillipa on February 17, 2007, at 21:45:46
In reply to Re: Lateralization of hand skills in Bipolar, posted by linkadge on February 17, 2007, at 16:52:05
Well I can't snap with my left hand so does this mean no bipolar even with the new categories of TRD? Love Phillipa
Posted by KayeBaby on February 18, 2007, at 2:30:10
In reply to Re: Lateralization of hand skills in Bipolar, posted by linkadge on February 17, 2007, at 16:52:05
> Intereresting. I am left handed. I am very messey.
>
> I have often wondered if my handedness is related to my issues.
>
> Linakdge
>
> Is there a large difference in abilities between the two hands? can you snap with both or do they have similar strengh and agility?I think it is that the fuctionality between the two hands varies so much. Did I understand the article correctly?
Peace,
Kaye
Posted by linkadge on February 18, 2007, at 8:36:15
In reply to Re: Lateralization of hand skills in Bipolar, posted by KayeBaby on February 18, 2007, at 2:30:10
Well, I know I didn't understand the article fully. Supposedly left handed people have right brain dominance. It was talking something about right hemispheric dysfunction.
I will have to read it again.
Linkadge
Posted by Phillipa on February 18, 2007, at 18:54:52
In reply to Re: Lateralization of hand skills in Bipolar, posted by linkadge on February 18, 2007, at 8:36:15
That's like a stroke if it happens on let's say the right side of the brain the left side is affected and vis versa. Love Phillipa
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.