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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by iforgotmypassword on February 12, 2007, at 6:41:42
both anti-glutamatergic? anti-excitotoxic?
yknow... in the direct effect sense, not just the floating brain substance? its actual relevant receptors? like how ketamine low dose is a nirvana somewhere yet we haven't heard much due to uhh, legality or umm laziness? or the retirement of jay a. goldstein? or perhaps writing off ketamine over how low low-dose ketamine should go? no it should not be anaesthetic, neither should it be visine. bla bla bla.
anyway...
uhh.
this is important. yeah yeah i know. this is the best that's coming out right now. i don't rewrite when i don't know how to get things wrote in the first place. i just thank the precious lord when it happens.
Posted by iforgotmypassword on February 12, 2007, at 6:48:28
In reply to gaba-b agonism and nmda antagonism alike?, posted by iforgotmypassword on February 12, 2007, at 6:41:42
taking memantine right now.
this is general route i am considering
fight glutamate, nmda activity, stregthen response to dopamine to where it is supposed to be to reinforce feeling, and action; fight head cement, fight task death, the grinding of metal in black and white (read: gray and gray)
i also would like to hear from acetylcholine on a few things. being my hoarding, indecision, apathy... ohhhh wait its all the same again. i said things better on aricept. i could combine. maybe worth a shot (in the head.)
Posted by rovers95 on February 12, 2007, at 10:00:56
In reply to executive function take two, posted by iforgotmypassword on February 12, 2007, at 6:48:28
> taking memantine right now.
>
> this is general route i am considering
>
> fight glutamate, nmda activity, stregthen response to dopamine to where it is supposed to be to reinforce feeling, and action; fight head cement, fight task death, the grinding of metal in black and white (read: gray and gray)
>
> i also would like to hear from acetylcholine on a few things. being my hoarding, indecision, apathy... ohhhh wait its all the same again. i said things better on aricept. i could combine. maybe worth a shot (in the head.)You wont get a strengthened response to dopamine or a stregnthened hpa axis, it jus doesn't bind as tightly as ket.
Although you will get the reduction in glutamate and should, like i did, get a good anti-anxiety effect, which i believe can improve depressive sympttoms as a result.
mark
Posted by saturn on February 12, 2007, at 14:32:57
In reply to gaba-b agonism and nmda antagonism alike?, posted by iforgotmypassword on February 12, 2007, at 6:41:42
Your reference to GABA-B caught my eye.
What about GABA-B ANtagonism?
Saegis/Novartis apparently is in Phase II trials of such a drug, currently called SGS-742, for ADHD.
I can't find *any* other information on it (I have even called them to no avail). Might anyone have *any* info regarding this?
This is the end of the thread.
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