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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Caedmon on November 19, 2006, at 8:38:38
Hi all
I am starting Lamictal (lamotrigine). I have been taking acetaminophen for those nasty Lamictal headaches, and that works okay.
I read that Lamictal goes through glucuronidation pathways (or, however it's called). But, so does acetaminophen if I'm understanding right. Does anyone know if there is an interaction? Thanks,
- Chris
Posted by ed_uk on November 19, 2006, at 11:51:05
In reply to Lamictal interact w/ acetaminophen / paracetamol?, posted by Caedmon on November 19, 2006, at 8:38:38
Hi Chris
I'm not aware of there being an interaction. I hope the Lamictal works well for you.
Regards
Ed
Posted by Phillipa on November 19, 2006, at 12:02:03
In reply to Re: Lamictal interact w/ acetaminophen / paracetamol? » Caedmon, posted by ed_uk on November 19, 2006, at 11:51:05
Me too. Love Phillipa
Posted by Quintal on November 19, 2006, at 15:03:02
In reply to Lamictal interact w/ acetaminophen / paracetamol?, posted by Caedmon on November 19, 2006, at 8:38:38
I took Lamictal for two years and used paracetamol a lot during that time. Had no unwanted effects from using the paracetamol and my liver is unscathed as far as I'm aware :-O
Paracetamol is not listed as a potential drug interaction in the patient information leaflet and I've never heard of this being a problem elsewhere.
Good luck with the Lamictal.
Q
Posted by Caedmon on November 20, 2006, at 5:57:58
In reply to Lamictal interact w/ acetaminophen / paracetamol?, posted by Caedmon on November 19, 2006, at 8:38:38
Okay, so doing some research, it looks like acetaminophen might decrease Lamictal levels.
_________________________
Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine.Clin Pharmacol Ther. 1990 Oct;48(4):346-55.
Depot M, Powell JR, Messenheimer JA Jr, Cloutier G, Dalton MJ.
Medical Department, Miles Canada Inc., Toronto, Etobicoke, Ontario.In this double-blind, randomized, crossover, placebo-controlled study, the effect of multiple oral doses of acetaminophen on lamotrigine disposition was examined in healthy volunteers. Eight volunteers received two single 300 mg oral doses of lamotrigine, administered 20 days apart. Acetaminophen (2.7 gm/day) or placebo was taken for 24 hours before and continued for 10 days after each lamotrigine dose. Area under the plasma concentration-time curve for lamotrigine [AUC(O-infinity)] and lamotrigine half-life were statistically decreased by 20% (229.0 +/- 62.5 micrograms.hr/ml versus 191.2 +/- 42.1 micrograms.hr/ml, p less than 0.01) and 15% (35.7 +/- 9.3 hours versus 30.2 +/- 7.3 hours, p less than 0.01), respectively, when concurrently administered with acetaminophen. There was no significant difference in the peak plasma concentration or the time to reach peak plasma concentration. The percentage of the dose of lamotrigine recovered in the urine (total) was significantly higher during the acetaminophen treatment (65.9% +/- 12.3% versus 72.5% +/- 5.7%, p = 0.048). Acetaminophen seems to facilitate lamotrigine removal through a yet to be determined mechanism(s).
This is the end of the thread.
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