![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by deniseuk190466 on November 10, 2006, at 13:26:59
I took 1mg of Klonopin the other night and all it did was make me feel even more flat.
If I had to compare Klonopin with Zyprexa, mood wise I feel much better taking 10mg of Zyprexa when compared with the 1mg of Klonopin.
Denise
Posted by yxibow on November 10, 2006, at 15:13:15
In reply to My verdict on Klonopin., posted by deniseuk190466 on November 10, 2006, at 13:26:59
> I took 1mg of Klonopin the other night and all it did was make me feel even more flat.
>
> If I had to compare Klonopin with Zyprexa, mood wise I feel much better taking 10mg of Zyprexa when compared with the 1mg of Klonopin.
>
>
> DeniseKlonopin, or any benzodiazepines can have a flattening feeling, by blunting affect and not allowing true emotions to come through. I do caution you but I am glad you're feeling well on Zyprexa, is that blunting is even greater on neuroleptics.
However, though my hands shook too much to continue on Zyprexa, I can concur that it is a very fast mood lifting agent and can completely replace also any benzodiazepines taken at the time. For some people, of course. This isn't a complete generalization
Good luck
-- Jay
Posted by fca on November 10, 2006, at 18:25:42
In reply to My verdict on Klonopin., posted by deniseuk190466 on November 10, 2006, at 13:26:59
Come again, for me that is a bit like saying when I am tired I feel better after taking methamphetamine than two shots of espresso--klonopin and Zyprexa are not even in the same league and have vastly different
pharmacology and modes of action. If Zyprexa provides you substantial relief (and it well may)it is treating more than uncomplicated anxiety. I am not minimizing the pain and anguish of anxiety (having been there)but I would be concerned if readers thought Zyprexa was readily available off label for anxiety. There have been studies suggesting its use for refractory anxiety or for persons unresponsive to SSRIs, TCAs or where Bzs may be contraindicated. I am not aware of Zyprexa being used PRN for anxiety although it probably would be sedating. Of the APs I am most familiar with using Seroquel for anxiety because of its relative safety profile vis a vis other APs and its sedating properties. I would appreciate other's comments.
Posted by blueberry on November 10, 2006, at 19:41:09
In reply to My verdict on Klonopin., posted by deniseuk190466 on November 10, 2006, at 13:26:59
I think, generally speaking, klonopin and zyprexa are two excellent medications. However, whether one treats a particular condition better than another varies from person to person. And it may vary from timeframe to timeframe. One medicatioin may act exactly as research supports that it would, or it could act totally the opposite. Or research could go completely in the trash while either of these meds brings some result that doesn't make much sense.
Simply, mileage varies. Psychiatric pharmacology is complicated and often unpredictable. I think what is important is to take information from personal trials and use it to your advantage and not get too concerned about why it is so or whether it makes any sense or not.
Posted by Phillipa on November 10, 2006, at 21:10:12
In reply to Re: My verdict on Klonopin., posted by blueberry on November 10, 2006, at 19:41:09
Well you can't take a benzo go off it and then just take an antipsychotic cause of withdrawal from the benzos. But they could be combined. I have tried seroquel. Wow it's strong compared to klonopin. Different classes of drugs. Love phillipa
Posted by Glydin on November 10, 2006, at 21:17:57
In reply to My verdict on Klonopin., posted by deniseuk190466 on November 10, 2006, at 13:26:59
> I took 1mg of Klonopin the other night and all it did was make me feel even more flat.
>~~~ On beginning Klonopin, I experienced some emotional flatness and mental fog that cleared by the time I had used it consistently for about 2 weeks. I can't speak to anything but that based on my experience.
Posted by yxibow on November 11, 2006, at 5:27:12
In reply to Re: My verdict on Klonopin., posted by Phillipa on November 10, 2006, at 21:10:12
> Well you can't take a benzo go off it and then just take an antipsychotic cause of withdrawal from the benzos. But they could be combined. I have tried seroquel. Wow it's strong compared to klonopin. Different classes of drugs. Love phillipa
You're probably more relating the H1 histamine sedation from Seroquel than the anxiety relief, unless I'm wrong ? I don't think you tried it that long.
Seroquel is heavily sedating and is not an example of what an average atypical neuroleptic does. At least not if you're not used to the rhinoceros stopping sedation.
Zyprexa is a bit different, in my opinion, in terms of transmitter binding -- it more heavily binds at muscarinic receptors in comparison (I've never quite understood these other than scary mushrooms, but they deal with cholinergic activities), and blockades 5HT2A, a site of hallucinogenic activity and one of the 5HT:D2 ratio sites of atypicals greater. It also is a thienobenzodiazepine derivative, shared only in structure with the highly esoteric benzodiazepine brotizolam. I wonder if there is anything more than a structural relation between the two. But at any rate though I probably shouldn't rechallenge Zyprexa with heavy handshaking, it made me sleep like it was a benzodiazepine. Quite curious.
The others you probably wouldn't want to try except at a small dose as the akathisia scale goes up sky high to Risperdal, of course this completely varies with some people snoring on Geodon and I'm crawling on the floor through up the walls.
-- tidings
Jay
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.