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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by blueberry on September 20, 2006, at 16:22:44
"Methylphenidate sensitization is modulated by valproate".
Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225, USA.
Repeated administration of psychostimulants such as amphetamine, cocaine, and methylphenidate has been shown to induce behavioral sensitization. Sodium valproate, an anticonvulsant agent that enhances GABA activity, and dizocilpine (MK-801), a non-competitive NMDA receptor antagonist, can block the sensitization elicited by psychostimulants.What does this mean? When they say depakote blocks the sensitization to repeated stimulants, does that mean it prevents getting immune to the effects of the repeated stimulants, or does it mean it just outright blocks the effects of the stimulants?
There were several abstracts on this subject and they all kind of gave me the impression that stimulants work smoother without developing tolerance when in the presence of depakote. But it all depends on what they mean by "behavioral sensitization", which is what I am hoping all you experts out there can help me with.
Posted by linkadge on September 20, 2006, at 16:38:27
In reply to What does this mean? Behavioral sensitization., posted by blueberry on September 20, 2006, at 16:22:44
I think (I could be wrong) that it probably blocks the induction of sterotypical behavior induced by repeated administration of stimulants.
Linkadge
Posted by zeugma on September 20, 2006, at 17:11:07
In reply to Re: What does this mean? Behavioral sensitization., posted by linkadge on September 20, 2006, at 16:38:27
Sensitization means 'augmented effect over time.' In the case of these studies, they are talking about stereotypic movements, number of beams crossed on an actimeter, etc.
-z
Posted by SLS on September 20, 2006, at 21:49:06
In reply to Re: What does this mean? Behavioral sensitization., posted by zeugma on September 20, 2006, at 17:11:07
It's about time you showed up, Z.
I came across a paper for you to take a look at a few months back. I posted looking for you, but you were absent. Let me see if I can find it again.
Got it.
Have a good day.
- Scott-------------------------------------------
Sleep Med. 2001 Jan;2(1):63-65. Related Articles, Links
Click here to read
Narcolepsy and obesity: remission of severe cataplexy with sibutramine.Krahn LE, Moore WR, Altchuler SI.
Mayo Sleep Disorders Center, Mayo Clinic and Foundation, 200 First Street, SW, MN 55905, Rochester, USA
An overweight patient (body mass index of 34 kg/m(2)) with narcolepsy associated with cataplexy is described. Polysomnography did not indicate obstructive sleep apnea. Her obesity was treated with sibutramine, a norepinephrine, serotonin and dopamine reuptake inhibiting medication and her severe cataplexy remitted. Clinicians must be aware that sibutramine may suppress cataplexy when evaluating excessive daytime sleepiness in an overweight patient taking this anti-obesity medication. Therefore a negative history of cataplexy in these cases may be misleading and narcolepsy may be overlooked in the differential diagnosis. Sibutramine should be discontinued before polysomnography and multiple sleep latency testing but may be a useful medication in the management of obese narcoleptic patients with cataplexy. With the discovery of decreased hypocretin 1 levels in humans with narcolepsy, a neuropeptide that modulates sleep and feeding, the association between narcolepsy and obesity requires more attention.
PMID: 11152984 [PubMed - as supplied by publisher]
Posted by Phillipa on September 20, 2006, at 22:16:38
In reply to Sorry for the interruption. » zeugma, posted by SLS on September 20, 2006, at 21:49:06
Blueberry are you any better and did you make up your mind? Love Phillipa
Posted by zeugma on September 21, 2006, at 7:36:53
In reply to Sorry for the interruption. » zeugma, posted by SLS on September 20, 2006, at 21:49:06
hi Scott,
I appreciated that you posted that to me a couple of months ago. Unfortunately I was not able to express this because I was blocked for the summer for making a tactless remark about the FDA(no doubt the feelings of partisans of current FDA policy were immensely cheered by my enforced absence- the cause of the gretaer good etc.)
I was disappointed that sibutramine did not work out for you. I think that maybe the muddiness you felt was a dopaminergic effect. Right now I am entertaining the thought that side effects/strange reactions are more prevalent when stimulation is applied to circuitry that is particularly broken down.
The anticataleptic effect of sibutramine is probably attributable to its NE/5HT reuptake properties. It would be interesting to try, although the last thing i need is a drug that promotes weight loss. from the little I've been able to find out about its pharmacology, it appears to be a very clean drug.
-z
This is the end of the thread.
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