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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by flip-floppy on September 2, 2006, at 11:33:40
After trying Abilify for some days, and giving it up because it produced too much anxiety, I'm back on amisulpride again. A low dosage of amisulpride really has an extraordinary ability to enable me to shrug off intrusive thoughts and "psychotic panic attacks" as I call it... I thought increasing dopamine was not advisable for psychotic persons, but, really, is cocaine, for example, bad for psychotic persons? I don't understand this stuff... Anyway, I plan to take amisulpride until I can get a script for Seroquel.
Posted by Jimmyboy on September 2, 2006, at 12:17:22
In reply to Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 11:33:40
How do you get Amisulpride in the US? Is there anything in the US that is similar?
Thanks
JB
Posted by flip-floppy on September 2, 2006, at 12:22:53
In reply to Re: Back on the stuff (amisulpride), posted by Jimmyboy on September 2, 2006, at 12:17:22
You have to order it from overseas pharmacies. Babble-mail me if you want a list. The most similar drugs would be amineptine and tianeptine, which you also have to order from abroad.
Posted by flip-floppy on September 2, 2006, at 13:11:29
In reply to Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 11:33:40
When taking amisulpride it makes me alert, sharp and concentrated, but taking 10 mgs of Zyprexa makes me stupid. Amisulpride actually let's me outsmart the "voices" (or whatever it is/they are...)
Posted by flip-floppy on September 2, 2006, at 13:17:47
In reply to Amisulpride makes me smart, Zyprexa makes me dumb, posted by flip-floppy on September 2, 2006, at 13:11:29
Posted by flip-floppy on September 2, 2006, at 13:33:32
In reply to Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 11:33:40
Posted by Jimmyboy on September 2, 2006, at 13:41:05
In reply to Can dopamine deficiency cause psychotic symptoms? (nm), posted by flip-floppy on September 2, 2006, at 13:33:32
Did you get my babblemail.. I am having troubles with it..
JB
Posted by flip-floppy on September 2, 2006, at 13:55:52
In reply to Re: Can dopamine deficiency cause psychotic symptoms?, posted by Jimmyboy on September 2, 2006, at 13:41:05
Posted by psychobot5000 on September 2, 2006, at 22:05:27
In reply to Re: Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 12:22:53
> You have to order it from overseas pharmacies. Babble-mail me if you want a list. The most similar drugs would be amineptine and tianeptine, which you also have to order from abroad.
I'm not sure how similar Tianeptine is to amisulpride--it doesn't have the same dopamine reuptake-inhibiting effects like amineptine does, but there does seem to be some indirect effect.
But the dopamine agonists Pramipexole and Ropinirole are thought to be similar to amisulpride, and available in the US. They all enhance dopamine action at the D2/D3 receptors, though amisulpride does it differently than the other two. However, they are primarily Parkinson's disease drugs, and would need to be prescribed 'off-label' for something else. However, an experienced and open-minded psychiatrist, might be willing to do it. There is pretty good evidence for Pramipexole's use in depression and other related things.
Posted by Jimmyboy on September 3, 2006, at 12:09:43
In reply to Re: Back on the stuff (amisulpride) Jimmyboy, posted by psychobot5000 on September 2, 2006, at 22:05:27
Thanks , I will look into those ..
JB
Posted by yxibow on September 3, 2006, at 15:43:55
In reply to Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 11:33:40
> After trying Abilify for some days, and giving it up because it produced too much anxiety, I'm back on amisulpride again. A low dosage of amisulpride really has an extraordinary ability to enable me to shrug off intrusive thoughts and "psychotic panic attacks" as I call it... I thought increasing dopamine was not advisable for psychotic persons, but, really, is cocaine, for example, bad for psychotic persons? I don't understand this stuff... Anyway, I plan to take amisulpride until I can get a script for Seroquel.
Amisulpride or Seroquel are atypical neuroleptics, they reduce dopamine, not increase it, majorly at a specific transmitter D2 (dopamine sub 2) but also others as well, D1-4 (I beleive), depending on the antipsychotic involved. Amisulpride does agonize (increase) though certain receptors at a low dose and antagonize at a higher dose. Seroquel to the best of my knowledge does not, I use it, although not for psychosis.
Was the "anxiety" on Abilify something you could describe as unnatural to anxiety you've experienced, like you wanted to pace or walk through walls? If so, that's akathisia, an EPS, or side effect of neuroleptics. Seroquel, lowest on the list besides Clozaril, does not typically show this.
Posted by flip-floppy on September 4, 2006, at 1:56:00
In reply to Re: Back on the stuff (amisulpride), posted by yxibow on September 3, 2006, at 15:43:55
The anxiety was not like akathisia (which I experienced on Thorazine -- it nearly made me kill myself, once.) Abilify worsened the anxiety that was already there, but amisulpride, on the other hand, is an excellent anxiolytic, in my opinion.
What I don't understand about amisulpride, is that dosages below 300 mg is supposed to enhance dopaminergic transmission (because it blocks the presynaptic dopamine D2/D3 autoreceptors.) So low-dose amisulpride should actually make me worse, but it doesn't.
Posted by flip-floppy on September 4, 2006, at 14:44:46
In reply to Re: Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 12:22:53
I just assumed that at least *some* of the pharmacies on the list I have, were selling amisulpride, but that might not be the case. Sorry.
Posted by psychobot5000 on September 8, 2006, at 10:41:11
In reply to Re: Back on the stuff (amisulpride), posted by Jimmyboy on September 2, 2006, at 12:17:22
If you still need amisulpride, babblemail me and I can point you somewhere.
This is the end of the thread.
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