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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by nickguy on August 3, 2006, at 19:17:46
I've failed so many meds, but I really don't feel like putting up with the fuss of an irreversible MAOI. I don't have enough energy or willpower to follow the diet, especially not being able to drink much alcohol. God knows why RIMA's arent approved in the U.S, but I know doctors in the US can write prescriptions to be filled overseas and mailed to the patient. I'm curious as to anybody's experience with these, but especially those in the United States who have manageed to get a prescription for them.
Posted by Meri-Tuuli on August 4, 2006, at 4:59:48
In reply to anybdy in the US take RIMA's(or international ppl), posted by nickguy on August 3, 2006, at 19:17:46
Hey there Nickguy,
I live in the UK and I have tried moclobemide, a RIMA that isn't available in the states. I think its the most popular RIMA out there, certainly in Europe. Yes there are people in the US who have got a prescription from their docs and had it filled in a European pharmacy and then had it shipped over. I get the impression that there are no significant hurdles to this practice.
Well my experience with moc - it unfortunately didn't last too long, because I developed a rash on my hands (which, I think in hindsight, was unrelated to the moc) and my pdoc thought it best to come off it (despite never having seen the rash). I generally don't like taking conventional medicines, so I was more than happy to stop.
Anyway it certainly works in the first few days. It gave me a significant energy boost, increased my socialability, stopped panic and did make me feel abit dizzy spaced out at times. But I didn't take it for long (maybe 1 and a half weeks?) and stopped because of the (unrelated?) rash.
Hmmm. According to some ancedotal reports, its one of those meds which you will know if it will work fairly quicky. And also it looks good on paper, but some people have found it disappointing. But then again, this happens with all meds.
Good luck!
Kind regards
Meri
Posted by nickguy on August 4, 2006, at 7:25:44
In reply to Re: anybdy in the US take RIMA's(or international » nickguy, posted by Meri-Tuuli on August 4, 2006, at 4:59:48
thank you ma'm. Anybody have any idea why they are not available in the US? I"m not particularly overly enthusiastic about RIMA's, but it would definetely be worth a shot just like all other meds.
Posted by SLS on August 4, 2006, at 7:41:13
In reply to Re: anybdy in the US take RIMA's(or international, posted by nickguy on August 4, 2006, at 7:25:44
> thank you ma'm. Anybody have any idea why they are not available in the US? I"m not particularly overly enthusiastic about RIMA's, but it would definetely be worth a shot just like all other meds.
Moclobemide could not get approved in the US because clinical trials conducted there did not demonstrate efficacy, even when tested for social phobia. Moclobemide fell into relative disuse around the world for perceived lack of efficacy. My guess is that the other RIMA drugs that had been in various stages of development were abandoned for this reason.
- Scott
Posted by silvercoin on August 4, 2006, at 7:48:48
In reply to Re: anybdy in the US take RIMA's(or international, posted by nickguy on August 4, 2006, at 7:25:44
> thank you ma'm. Anybody have any idea why they are not available in the US? I"m not particularly overly enthusiastic about RIMA's, but it would definetely be worth a shot just like all other meds.
My assumption is that either they did not show sufficient efficacy in clinical trials and/or no company felt it worth the effort to pursue. My impression is that reversible MAOIs are inferior to the irreversible ones in terms of antidepressant efficacy. As for alcohol consumption, as long as tap beer is not consumed, you can have at least two drinks a day on any MAOI. This figure is really based on a worse case scenario involving Parnate; and my feeling is that on Marplan, Nardil, or EMSAM, you can go way beyond this.Todd
Posted by willyee on August 4, 2006, at 12:18:49
In reply to Re: anybdy in the US take RIMA's(or international, posted by silvercoin on August 4, 2006, at 7:48:48
> > thank you ma'm. Anybody have any idea why they are not available in the US? I"m not particularly overly enthusiastic about RIMA's, but it would definetely be worth a shot just like all other meds.
>
>
> My assumption is that either they did not show sufficient efficacy in clinical trials and/or no company felt it worth the effort to pursue. My impression is that reversible MAOIs are inferior to the irreversible ones in terms of antidepressant efficacy. As for alcohol consumption, as long as tap beer is not consumed, you can have at least two drinks a day on any MAOI. This figure is really based on a worse case scenario involving Parnate; and my feeling is that on Marplan, Nardil, or EMSAM, you can go way beyond this.
>
> ToddMaois themelves can be tricky to keep working,rimas are that much harder,personaly i find the most common one,molicmide to be best at being an augmentation drug.
Posted by Phillipa on August 4, 2006, at 16:29:31
In reply to Re: anybdy in the US take RIMA's(or international, posted by willyee on August 4, 2006, at 12:18:49
Willyee you're back I'm e-mailing you a question someone said you had the answer to. Love Phillipa
This is the end of the thread.
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