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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on July 23, 2006, at 3:13:54
This is an OTC antihistamine which zimelidine was derived from. It supposedly is a fairly strong SSRI itself, though I don't know the exact potency.
Anyhow, has anyone tried it in SSRI like applications ?
Linkadge
Posted by SLS on July 23, 2006, at 8:57:00
In reply to Anyone used chlorpheniramine ?, posted by linkadge on July 23, 2006, at 3:13:54
Hi Linkadge.
> This is an OTC antihistamine which zimelidine was derived from. It supposedly is a fairly strong SSRI itself, though I don't know the exact potency.
>
> Anyhow, has anyone tried it in SSRI like applications ?
It is my belief that the reason diphenhydramine acts to mitigate the withdrawal symptoms associatied with the discontinuation syndrome of the various SRI drugs is precisely because it inhibits the reuptake of serotonin. It is likely that the anticholinergic properties help out there too in some cases. This might apply to drugs with NE reuptake inhibition or anticholinergic properties. I'm just guessing though.To what extent is chlorpheniramine anticholinergic?
- Scott
Posted by djmmm on July 23, 2006, at 15:58:27
In reply to Anyone used chlorpheniramine ?, posted by linkadge on July 23, 2006, at 3:13:54
> This is an OTC antihistamine which zimelidine was derived from. It supposedly is a fairly strong SSRI itself, though I don't know the exact potency.
>
> Anyhow, has anyone tried it in SSRI like applications ?
>
> http://jlmeek.com/postdoc/
>
> LinkadgeHey...I've used it, not as a primary medication, but it completely stops the "brain zaps' associated with ssri discontinuation (for me at least)
Posted by linkadge on July 23, 2006, at 16:33:43
In reply to Re: Anyone used chlorpheniramine ? » linkadge, posted by SLS on July 23, 2006, at 8:57:00
Chlorpheniramine is supposedly a stronger SSRI than benadrly, yet weaker anticholinergic properties. It does have strong antihistamine effects though, and would probably need to be taken at night.
Linkadge
Posted by linkadge on July 23, 2006, at 16:35:12
In reply to Re: Anyone used chlorpheniramine ?, posted by djmmm on July 23, 2006, at 15:58:27
I picked some up from the pharmacy. I'm going to see if a low dose can reverse some of my problems with movement.
If it works, it may be more taperable.
There are case reports of mood improvement on it.
Linkadge
Posted by linkadge on July 23, 2006, at 19:12:20
In reply to Re: Anyone used chlorpheniramine ?, posted by linkadge on July 23, 2006, at 16:35:12
It feels a lot like an SSRI. Kindof like clomipramine. Drowsiness, and some mild deleriant like effects though.
Linkadge
Posted by Caedmon on July 23, 2006, at 20:42:04
In reply to Anyone used chlorpheniramine ?, posted by linkadge on July 23, 2006, at 3:13:54
I've taken it lots, for allergies. It must not have strong SRI properties at least for me. I've taken bunches (well, up to 24mg/day) along with Parnate and it didn't interact at all, so either it's not that strong or it has the... crud, those 5ht2a (?) antagonist properties or whatever it is that is considered protective against serotonin toxicity.
I don't think it has very strong anticholinergic properties, esp. compared to diphenhydramine. To me it is/was just a fairly good allergy med. I never even feel sleepy on it.
Best of luck,
- Chris
This is the end of the thread.
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