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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Don_Bristol on May 16, 2006, at 19:14:22
Parnate inhibits of monoamine oxidase with the result that certain neurotransmitters become raised.
One web page says that it increases the concentration of epinephrine, norepinephrine, and serotonin.
Do you know which of these neurotransmitters it affects the most and by how much more than the others?
(Just as an aside, do Nardil and Marplan affect the same neurotransmitters in the same degree?)Don
Posted by willyee on May 16, 2006, at 19:59:36
In reply to Which neurotransmitters does Parnate affect?, posted by Don_Bristol on May 16, 2006, at 19:14:22
Parnate stands unique among many meds even maois due to its effect on dopamine also,try doing a parnate/dopamine google search,use the key words biopsychatiary also i know they have a good aritcle somewhere on how parnate has a unique mode of action that is only a result of parnate,its affect on dopamine i mean.
Posted by Jost on May 16, 2006, at 20:17:36
In reply to Re: Which neurotransmitters does Parnate affect?, posted by willyee on May 16, 2006, at 19:59:36
It affects all neurotransmitters that are broken down by monoamine oxidase, which includes dopamine, noradrenaline, and serotonin.
Those are the main three neurotransmitters that are targetted by makers of ADs, at this point.
Jost
Posted by willyee on May 16, 2006, at 21:08:42
In reply to Re: Which neurotransmitters does Parnate affect?, posted by Jost on May 16, 2006, at 20:17:36
I could be wrong but i dont think Nardil touches dopamine much at all,as Parnate doesent touch GABA at all,in fact there was a study done on these speicific two,i can probuably fine it,where parnate was used to lower gaba transmission,a side effect from Nardil use,so in the study both were used,so oviously no washout period was exsistent.
I can confirm at least that much personaly,i have attempted Nardil trials a few times only to RUN back to parnate,and in the mean time ended up on both in doing so,this was on more than a single occasion.
Parnate like Midfanil lowers gaba,which is why a lot of people usualy use a benzo with it even if its not daily use but semi daily.
Nardil with its serotnioninic and gaba enhancment make it a very calming drug,for some people TOO calmming and the lack of that STIMULANT effect is needed which is why a lot of people look to add stimulants,ill look for the article.
Posted by djmmm on May 16, 2006, at 21:41:38
In reply to Which neurotransmitters does Parnate affect?, posted by Don_Bristol on May 16, 2006, at 19:14:22
Parnate increases all monoamines-- the catecholamines (Dopamine, norepinephrine, and epinephrine), Serotonin, Histamine, and many other trace amines.
Some studies of long term exposure to MAOI's, show a greater increase in Serotonin, as opposed to the other monoamines-- regardless of the fact that Parnate is a non selective MAOISome studies also suggest that Parnate has the ability to block the re-uptake of catecholamines.
Nardil is unique in that one of it's metabolites is a inhibitor of GABA transaminase, as a result, GABA is increased.
Posted by Phillipa on May 16, 2006, at 22:45:08
In reply to Re: Which neurotransmitters does Parnate affect?, posted by djmmm on May 16, 2006, at 21:41:38
Well if I don't do EMSAM and do an Maoi then it's nardil I need the sedation. Anxiety is my biggest issue. Thanks Phillipa
Posted by Jost on May 16, 2006, at 23:04:50
In reply to Re: Which neurotransmitters does Parnate affect? » djmmm, posted by Phillipa on May 16, 2006, at 22:45:08
Got this from wikipedia:
"MAOIs act by inhibiting the activity of monoamine oxidase preventing the breakdown of monoamine neurotransmitters and so increasing the available stores. There are two isoforms, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, adrenaline and noradrenaline. MAO-B preferentially deaminates phenylethylamine and trace amines. Dopamine is equally deaminated by both types."
Jost
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