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Dr. Bob is Robert Hsiung, MD,
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Posted by TomG on May 14, 2006, at 12:12:34
I ask this because Seroquel gives me consistent quality deep sleep.
I'm struggling with insomnia. I've tried Lunesta, Ambien CR, 25mgs Benadryl, Ativan. Everything above will put me out, but I wake up early and don't feel like I've slept at all. I'm not reaching deep sleep. I feel great mood wise have mental energy etc. but I sort of feel tired like I need sleep during the day. Tired but not sleepy. My eyes look like hell.
The Benadryl that I used worked the first night and gave me pretty good rest, but the second night it did not work. I will try 50-75mgs and see what that does.
What I need to know does *low dose* Seroquel have signifigant dopamine antagonism. It has never failed at providing the best sleep I've ever had. Although I'm taking 25mgs amisulpride a day, and it's working great for my symptoms, and I don't want to jinx anything.
Tom
Posted by blueberry on May 14, 2006, at 18:51:52
In reply to Does Low Dose Seroquel Have Dopamine Antagonism?, posted by TomG on May 14, 2006, at 12:12:34
As far as I understand, Seroquel has the lowest amount of dopamine antagonism of them all. And since the amount of antagonism is directly related to the size of the dose, I would guess the amount of antagonism at the doses you are talking about is pretty low. Probably not anywhere near enough to disturb amisulpride.
I have read in studies where they added amisulpride to full doses of other antipsychotics to treat residual negative symptoms and it was generally effective.
I used 25mg amisulpride with 5mg zyprexa and could feel the amisulpride stimulation. Sexual side effects were real bad for me though, so I did not make it past week 2.
Just an opinion and just an educated guess, but I think you should be all set.
Nighty night. Sleep good!
Posted by TomG on May 15, 2006, at 14:07:27
In reply to Re: Does Low Dose Seroquel Have Dopamine Antagonism? » TomG, posted by blueberry on May 14, 2006, at 18:51:52
This is the end of the thread.
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