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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by TJO on May 3, 2006, at 6:05:09
Hi All,
Was reading yesterday that this was/is supposed to be a new antidepressant. Is it out yet? Any success stories?Thanks
Tam
Posted by ed_uk on May 3, 2006, at 9:14:15
In reply to Aprepitant, posted by TJO on May 3, 2006, at 6:05:09
Hi Tam,
>Is it out yet?
Yes, but not as an antidepressant. It's available as an antiemetic to prevent nausea and vomiting caused by cancer chemotherapy.
Here is some information.....
'Aprepitant is a neurokinin-1 (NK-1)-receptor antagonist (substance P antagonist)'
'Aprepitant was in Phase II studies expected to be an effective antidepressant, but Phase III studies failed to show efficacy in the treatment of depression. Aprepitant's failure in depression sounds a warning for substance P antagonists - it is not the first drug in this class to be suspended from trials in depression.'
Regards
Ed
Posted by ben on May 3, 2006, at 14:42:28
In reply to NK-1 antagonists » TJO, posted by ed_uk on May 3, 2006, at 9:14:15
Hi Ed_uk
which drug was eliminated in clinical trials beside this NK1-antagonist? I hope not Saredutant!?
Ben
This is the end of the thread.
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