Psycho-Babble Medication Thread 627344

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how is welbutrin different from abilify, seroquel

Posted by platinumbride on March 31, 2006, at 22:41:16

I Do understand that one is and AD and the others antipsychotics, but if they both work on dopamine, why does abilify make bipolar 2 depression better, while wellbutrin does zero?

Thanks,

Diane

Re: how is welbutrin different from abilify, seroq » platinumbride

Posted by yxibow on April 1, 2006, at 4:06:52

In reply to how is welbutrin different from abilify, seroquel, posted by platinumbride on March 31, 2006, at 22:41:16

> I Do understand that one is and AD and the others antipsychotics, but if they both work on dopamine, why does abilify make bipolar 2 depression better, while wellbutrin does zero?
>
> Thanks,
>
> Diane

Abilify, as an atypical antipsychotic, targets and antagonizes (for a specified length of time and strength) a specific dopamine receptor, D2, while the metabolites of Wellbutrin are general norepinephrine and dopamine reuptake inhibitors.

Re: how is welbutrin different from abilify, seroq » yxibow

Posted by platinumbride on April 1, 2006, at 5:20:57

In reply to Re: how is welbutrin different from abilify, seroq » platinumbride, posted by yxibow on April 1, 2006, at 4:06:52

Thank you, yxibow.

What do you mean for a "specificed amount of time"? Am I going to be back where I was, vis a vis depression within 6 months?

Thanks again,

Diane

> > I Do understand that one is and AD and the others antipsychotics, but if they both work on dopamine, why does abilify make bipolar 2 depression better, while wellbutrin does zero?
> >
> > Thanks,
> >
> > Diane
>
> Abilify, as an atypical antipsychotic, targets and antagonizes (for a specified length of time and strength) a specific dopamine receptor, D2, while the metabolites of Wellbutrin are general norepinephrine and dopamine reuptake inhibitors.

Re: how is welbutrin different from abilify, seroq » platinumbride

Posted by yxibow on April 1, 2006, at 12:19:35

In reply to Re: how is welbutrin different from abilify, seroq » yxibow, posted by platinumbride on April 1, 2006, at 5:20:57

> Thank you, yxibow.
>
> What do you mean for a "specificed amount of time"? Am I going to be back where I was, vis a vis depression within 6 months?

Oh, no, I was talking about how strong a particular antipsychotic grabs the D2 receptor in particular.

Haloperidol (Haldol) occupies it basically 100%, and grabs on like no tomorrow, producing a lot of nasty side effects in the way (does the same for a lot of the Dx receptors). Things like Seroquel occupy it for a short time and then release it, and then grab it again. Less EPS (side effects, specifically usually used as a term for antipsychotics), theoretically though I have some odd EPS. Nothing like Compazine though which I had in the hospital for flu -- its at least as nasty as Haldol and has profuse akathisia.

Re: how is welbutrin different from abilify, seroq » yxibow

Posted by Phillipa on April 1, 2006, at 20:00:20

In reply to Re: how is welbutrin different from abilify, seroq » platinumbride, posted by yxibow on April 1, 2006, at 12:19:35

I'm confused too since wellbutrin is an AD and abilfy is an antipsychotic. Love Phillipa

Re: how is welbutrin different from abilify, seroq

Posted by Caedmon on April 1, 2006, at 23:07:31

In reply to how is welbutrin different from abilify, seroquel, posted by platinumbride on March 31, 2006, at 22:41:16

As far as I know, Wellbutrin can be used for bipolar depression so long as you are on adequate mood stabilizer(s) and aren't 'cycling'. <shrug>

- C

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