![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by lostforwards on March 19, 2006, at 10:45:05
How effective is effexor as an NRI? For a dose of, say, 75mg/day. What are some of the other NRIs available?
Posted by Racer on March 19, 2006, at 12:12:58
In reply to Effexor as an NRI, posted by lostforwards on March 19, 2006, at 10:45:05
> How effective is effexor as an NRI? For a dose of, say, 75mg/day. What are some of the other NRIs available?
I think Effexor has to be higher to hit NE receptors, but don't really know the thresholds.
As for other NRIs:
Strattera is a Selective Norepinephrine Reuptake Inhibitor. I believe it's the only actual SNRI at this point.
Cymbalta is a balanced 5HT and NE reuptake inhibitor.
Wellbutrin inhibits the reuptake of NE and DA.
Amphetamines inhibit the reuptake of NE and DA.
Nortriptyline is an NRI.
Desipramine is an NRI.
Amitriptyline is an NRI.
There are other NRIs in the TCA class, but I don't know all the names.
Hope that helps.
Posted by greywolf on March 19, 2006, at 22:10:00
In reply to Re: Effexor as an NRI » lostforwards, posted by Racer on March 19, 2006, at 12:12:58
Most of the info I've read says Traz is an NRI, but I've seen a couple studies that reject the proposition. One found that Traz does not inhibit NE reuptake, but may enhance NE release. But the bulk of the reports accept that Traz inhibits NE.
Posted by TylerJ on March 24, 2006, at 9:36:45
In reply to Racer: is Trazadone an NRI?, posted by greywolf on March 19, 2006, at 22:10:00
>
> Most of the info I've read says Traz is an NRI, but I've seen a couple studies that reject the proposition. One found that Traz does not inhibit NE reuptake, but may enhance NE release. But the bulk of the reports accept that Traz inhibits NE.
I'm not Racer, however I'm taking Trazodone so I'll tell you what i know about it. Traz is a Triazolopyridine with a 1/2 life of 4 - 9 hrs. Traz inhibits presynaptic serotonin, and has mild postsynaptic serotonergic antagonism. It is also a potent antihistamine which causes it's sedation effect and possible weight gain. Traz also causes marked inhibition of alpha-1-adrenergic receptors which can lead to severe hypotension. For me, 200mgs. at bedtime helps tremendously for my moai induced insomnia. Any more than 200 causes daytime drowsiness for me.Tyler
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.