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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by tessellated on March 13, 2006, at 18:11:26
I've found sleep deprivation to be a great way around parnate insomia. I stay awake 36 hrs and then sleep solidly for about 12hrs.
Is prolonged sleep deprivation of this sort dangerous?
(i'm speaking physically not from impaired driving etc..) or is this simplistic and idiosynchratic?
http://essentialpsychopharmacology.com/articles/66_4.htmlConversely, I've also read numerous case studies about individuals who cannot sleep (and/or do not REM) due to (brain damage, etc), and who show no siginficant ill effects.
In doing this I'm able to have deep restfull sleep without the use of sleep aids-and get a whop load done.
Parnate makes sleep look like death, when just days ago it was an escape....
I do know sleep deprivation is the most empirically proven form of a "homeopathic treatment to depression.
Can anyone unravel the mysteries of sleep?
Posted by linkadge on March 13, 2006, at 20:13:58
In reply to Sleep deprivation for Parnate insomnia?, posted by tessellated on March 13, 2006, at 18:11:26
Sleep can play a strange role in depression. I think that in apathy and anhedonia that sleep deprivation can help, but in cases of neurosis/psychosis that sleep is definately needed.
I would think that there would be definate consequences of going without sleep for too long.
But now and again is probably fine.Linkadge
Posted by linkadge on March 13, 2006, at 20:15:25
In reply to Re: Sleep deprivation for Parnate insomnia?, posted by linkadge on March 13, 2006, at 20:13:58
For me, SD is the only antidepressant that really works. All others are only work insofar as they give me insomnia.
Linkadge
Posted by tessellated on March 14, 2006, at 17:46:34
In reply to Re: Sleep deprivation for Parnate insomnia? » linkadge, posted by linkadge on March 13, 2006, at 20:15:25
Link, I agree,
here are a bunch of studies on the AD of SD. The therapuetic benefits are statisticaly remarkable. I recall that this was discovered before the monoamine hypothesis leading them to think that depression was caused by some endogenous agent released during sleep, leading partially to the theories on melatonin. Its still unclear how AD's REM suppression fits in.
http://www.psycom.net/depression.central.sleepdep.htmlthe adverse health effects listed here:
http://essentialpsychopharmacology.com/articles/66_4.htmlThey correlate sleep deprivation to a cortisol related accelleration of the ageing process, diabetes, and obesity. I wonder if through the use of parnate or provigil, one could avoid the cortisol release simply by enjoying the sleep deprivation rather than perceiveing it as adverse or threatening. I know that glucocorticotropins (stress hormones) and their releasing factor GRF is directly related to the organismsms perception of stress, not the stress itself.
Therefore is one doesn't perceive sleep deprivation as uncomfortable then perhaps all those bad affects could be avoided?
This would be a rather tricky experiment to pull off double blind.tessl8
Posted by linkadge on March 14, 2006, at 21:14:42
In reply to Sleep Deprivation AntiDepressants, posted by tessellated on March 14, 2006, at 17:46:34
Sleep deprivation affects the monoamines. Sleep deprivation increases hippocampal serotonin, sometimes that inrease lasts a few days after the SD night.
SD actually affects all three of the monoamines to varying extends and in different ways.
Sleep deprivation increases the sensitivity of the d2 receptors. It is funny, because sucessfull treatment with many antidepressants increases the sensitivity of the d2 receptors.
I honestly don't understand it.
The sucess of SD tells me that the brain has full capability of putting itself into remission.
But its complex, because when you induce depression in animals (by stressing them unavoidably) they develop sleep abnormalities, in particular REM sleep abnormalities.
So, I don't get it, but it angers me that a cure is "right there" but just inacessable.
SSRI's only worked for me when they reduced the amount of sleep I got.
Linkadge
This is the end of the thread.
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