Psycho-Babble Medication Thread 614567

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Lamictal / Neurontin Drug Interaction.

Posted by Sobriquet Style on March 1, 2006, at 6:27:39

Would anyone be able to point me into the direction (provide links) of information confirming there is no interaction between Lamictal (Lamotrigine) and Gabapenein (Neurontin)

Thanks in Advance

:-)

~

Re: Lamictal / Neurontin Drug Interaction.

Posted by SLS on March 1, 2006, at 6:58:00

In reply to Lamictal / Neurontin Drug Interaction., posted by Sobriquet Style on March 1, 2006, at 6:27:39

> Would anyone be able to point me into the direction (provide links) of information confirming there is no interaction between Lamictal (Lamotrigine) and Gabapenein (Neurontin)
>
> Thanks in Advance
>
> :-)
>
> ~

The NIMH did a few studies combining these two drugs. No adverse events were reported. You should be able to find the abstract to these studies on Medline:

http://www.pubmed.gov

If you can't find anything there, try this:

http://www.bipolarnews.org/pdfs/bnnvol6iss1.pdf

I tried the combination once. It really didn't help me, but the NIMH seemed to think that the two drugs together were better than either one alone.

- Scott

Re: Lamictal / Neurontin Drug Interaction.

Posted by Sobriquet Style on March 1, 2006, at 9:08:56

In reply to Re: Lamictal / Neurontin Drug Interaction., posted by SLS on March 1, 2006, at 6:58:00

>http://www.pubmed.gov

Thanks for the link...

>You should be able to find the abstract to these studies on Medline:

I was unable to find the abstract about the study of Lamotrine and Gabapentin, but I did find these...

Levetiracetam, gabapentin and pregabalin have not been reported to cause or be a target for clinically relevant pharmacokinetic drug interactions.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16487217&query_hl=1&itool=pubmed_docsum

Several newer AEDs used in BPD also offer the advantages of fewer drug interactions and less need for therapeutic drug monitoring compared with older AEDs.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16403851&query_hl=1&itool=pubmed_docsum

In addition, newer AEDs appear to have a more favourable tolerability and drug interaction profile as compared to older compounds, so thus improving compliance to treatment.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15246950&query_hl=1&itool=pubmed_docsum

I think you may take Levetiracetam? I found this too, so thought I'd post it as it may be of some interest with interactions.. :-)

Levetiracetam did not increase or decrease mean steady-state serum concentrations of carbamazepine, phenytoin, valproic acid, lamotrigine, gabapentin, phenobarbital, or primidone.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15823510&query_hl=1&itool=pubmed_docsum

>http://www.bipolarnews.org/pdfs/bnnvol6iss1.pdf

Thanks for that link Scott. :-)

I'll try again to see if I can access it from Pubmed, but I don't think I'll have any luck for some reason, I searched about 100, but still no luck :-( lol

~

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