Psycho-Babble Medication Thread 610302

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Prozac - 100 mg or more

Posted by Maxime on February 16, 2006, at 15:08:23

Has anyone here been on a 100 mg or more of Prozac? I think I was on a 100 mg before, but didn't notice much difference between 80 and 100. Has anyone take 120 mg? Did it help?

Maxime

Re: Prozac - 100 mg or more » Maxime

Posted by john berk on February 16, 2006, at 15:35:16

In reply to Prozac - 100 mg or more, posted by Maxime on February 16, 2006, at 15:08:23

Hi, i had a close friend who was on 120 mgs. of prozac, he said he also didn't feel much difference between that dose and 80 mgs, but he was overall quite med resistant, i have read that some people do great on 100 mgs. or more...john

Re: Prozac - 100 mg or more

Posted by blueberry on February 16, 2006, at 16:34:27

In reply to Prozac - 100 mg or more, posted by Maxime on February 16, 2006, at 15:08:23

I've heard of prozac doses as high as 180mg. I wonder though how prozac's mechanism changes, if at all, at high doses, because I think the serotonin reuptake pumps are already completely 100% blocked at around 60mg to 80mg.

Re: Prozac - 100 mg or more

Posted by vainamoinen on February 16, 2006, at 18:38:14

In reply to Prozac - 100 mg or more, posted by Maxime on February 16, 2006, at 15:08:23

I took 120 mg once by accident, I usually take 60 mg but I forgot I had already taken my dose so I doubled up by accident.

I was irritable as hell that day, really cranky.

I'm bipolar II so things like that are destabilizing I guess.

Re: Prozac - 100 mg or more

Posted by Phillipa on February 16, 2006, at 21:54:56

In reply to Re: Prozac - 100 mg or more, posted by vainamoinen on February 16, 2006, at 18:38:14

20mg sent me over the edge by the third day. Boy are we all different!!!!Fondly, Phillipa

Re: Prozac - 100 mg or more

Posted by SLS on February 17, 2006, at 8:10:46

In reply to Re: Prozac - 100 mg or more, posted by blueberry on February 16, 2006, at 16:34:27

> I've heard of prozac doses as high as 180mg. I wonder though how prozac's mechanism changes, if at all, at high doses, because I think the serotonin reuptake pumps are already completely 100% blocked at around 60mg to 80mg.

Norepinephrine? It might be just as effective to add desipramine. Linkage can probably better answer this question. These drugs do so many different things.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9451727&query_hl=4&itool=pubmed_docsum

The other possibility is that it takes a high concentration of Prozac in the blood to reach certain target tissues in the brain.

- Scott

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