![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by TJO on February 2, 2006, at 6:30:46
Hi All,
I presently take 800 mg of Seroquel. I recently upped the dose from 700 to 800mg. I felt a LOT better. I tried 900 mg for a couple of days and felt better still. I have a pdoc appt on Feb 9th, and am going to try to convince him to let me take the 900 mg. A great friend found me an article on a study that was done in Europe where doses from 900 to 1600 mg were administered with no adverse affects. My question is this,
Have any of you tried Seroquel at any doses higher than 800 mg, and if so, what were the results?Thanks so much
Tam
Posted by yxibow on February 2, 2006, at 12:18:16
In reply to High Dose Seroquel ?, posted by TJO on February 2, 2006, at 6:30:46
> Hi All,
> I presently take 800 mg of Seroquel. I recently upped the dose from 700 to 800mg. I felt a LOT better. I tried 900 mg for a couple of days and felt better still. I have a pdoc appt on Feb 9th, and am going to try to convince him to let me take the 900 mg. A great friend found me an article on a study that was done in Europe where doses from 900 to 1600 mg were administered with no adverse affects. My question is this,
> Have any of you tried Seroquel at any doses higher than 800 mg, and if so, what were the results?
I am currently at 975mg of Seroquel, partially because another drug has shifted my blood levels, so that would be more like 900mg, but Seroquel has a very wide range of dose levels. I have taken as high as 1000+. It is weak at the D2 levels so higher doses may be necessary for certain conditions, e.g. schizophrenia. I take it for other reasons.The results are what could be expected, increased effectiveness, but more EPS, tending in the milder form, not akathisia. Your miles may vary as they say.
Jay
Posted by TJO on February 2, 2006, at 16:15:37
In reply to Re: High Dose Seroquel ? » TJO, posted by yxibow on February 2, 2006, at 12:18:16
Posted by bipolarspectrum on February 3, 2006, at 0:01:46
In reply to High Dose Seroquel ?, posted by TJO on February 2, 2006, at 6:30:46
Hey,
I was taking 900mg at night for awhile with lithium... it worked really really well... but it knocked me out for like 12/13 hours at night
and there was possibly some mental cloud with the lithium....
bps
Posted by yxibow on February 3, 2006, at 0:32:38
In reply to Re: High Dose Seroquel ?, posted by bipolarspectrum on February 3, 2006, at 0:01:46
> Hey,
> I was taking 900mg at night for awhile with lithium... it worked really really well... but it knocked me out for like 12/13 hours at night
> and there was possibly some mental cloud with the lithium....
> bpsYes, forgot to add the increased daytime sedation issue as it goes up. Passable if you can stand caffeine or something, I can't much.
Posted by SLS on February 4, 2006, at 7:16:55
In reply to Re: High Dose Seroquel ? » TJO, posted by yxibow on February 2, 2006, at 12:18:16
> I am currently at 975mg of Seroquel, partially because another drug has shifted my blood levels, so that would be more like 900mg, but Seroquel has a very wide range of dose levels. I have taken as high as 1000+. It is weak at the D2 levels so higher doses may be necessary for certain conditions, e.g. schizophrenia. I take it for other reasons.
Indeed, such a high dosage of Seroquel might indicate a need for low dosages of a stronger D2 antagonist (one with higher binding affinity) like Risperdal. However, Seroquel is now being looked at closely to assess its potential antidepressant effects. Actually, combining Risperdal with small dosages of Seroquel can have amazing therapeutic effects to clear-up thinking and produce an energizing effect.
- Scott
Posted by ed_uk on February 4, 2006, at 11:37:40
In reply to Re: High Dose Seroquel ?, posted by SLS on February 4, 2006, at 7:16:55
Hi Scott
>Indeed, such a high dosage of Seroquel might indicate a need for low dosages of a stronger D2 antagonist (one with higher binding affinity) like Risperdal.
I would imagine that combining Seroquel with sulpiride (Dolmatil) or amisulpride (Solian) might also be a useful treatment for psychosis.
Ed
Posted by yxibow on February 4, 2006, at 13:04:42
In reply to Re: High Dose Seroquel ?, posted by SLS on February 4, 2006, at 7:16:55
> > I am currently at 975mg of Seroquel, partially because another drug has shifted my blood levels, so that would be more like 900mg, but Seroquel has a very wide range of dose levels. I have taken as high as 1000+. It is weak at the D2 levels so higher doses may be necessary for certain conditions, e.g. schizophrenia. I take it for other reasons.
>
> Indeed, such a high dosage of Seroquel might indicate a need for low dosages of a stronger D2 antagonist (one with higher binding affinity) like Risperdal. However, Seroquel is now being looked at closely to assess its potential antidepressant effects. Actually, combining Risperdal with small dosages of Seroquel can have amazing therapeutic effects to clear-up thinking and produce an energizing effect.
Don't get me near Risperdal (Haloperidol in chemical disguise) again... I still have a right index finger that twitches slightly from a low dose. Seroquel is about the only neuroleptic I can handle without major EPS. Abilify was disappointing even, because it caused akathisia, not quite as skin crawling as Geodon but noticeable. Zyprexa caused pseudoparkinsonism, twice, on two trials and I've never quite regained 100% control of my hands -- although the Seroquel could be continuing it on a very minor basis.At a high dose, you're right, it has more of a binding affinity, but it releases it more quickly unlike Risperdal and traditional neuroleptics. The only reason I am taking it, is for the D2 effect, but it is for a rare visual related somatiform condition.
EPS and quality of life from side effects is something that seemed to be completely ignored (especially for people with nonpsychotic or parapsychotic affective disorders) in the recent article that novel neuroleptics were not particularly better than "old line" ones.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.