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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by fachad on January 5, 2006, at 18:29:42
I've heard that because of properties at alpha receptors which become more pronounced at "higher" doses, and eventually eclipse the histamine receptor (sedative) effect - because of that Remeron is actually LESS sedating at HIGHER does.
Does this resonate with people's actual experiences?
The usual anecdote is that at "higher" doses - said to be around 45 mg or 60 mg - Remeron is less sedating. Does that mean that Remeron becomes MORE sedating as the dose increases, UNTIL it goes above 30mg? So is 30 mg more sedating than 15 mg; and 15 mg is more sedating than 7.5 mg? Or are there some people find the alpha thing to kick in at the 30mg dose, making the ideal dose for sleep to be 15 mg?
I know that YMMV, but I'm wondering what mileage people actually get, and how much that jibes with the theoretical data/marketing claims of the manufacturer.
Posted by fires on January 5, 2006, at 18:50:14
In reply to What dose of Remeron is most sedating?, posted by fachad on January 5, 2006, at 18:29:42
>
> The usual anecdote is that at "higher" doses - said to be around 45 mg or 60 mg - Remeron is less sedating. Does that mean that Remeron becomes MORE sedating as the dose increases, UNTIL it goes above 30mg? So is 30 mg more sedating than 15 mg; and 15 mg is more sedating than 7.5 mg?For me 7.5 mg was most sedating. 15 mg: sedation dropped for me. Definitely no sedation at 30 mg.
Posted by Declan on January 6, 2006, at 1:24:04
In reply to Re: What dose of Remeron is most sedating? » fachad, posted by fires on January 5, 2006, at 18:50:14
Hey Fires, I'm interested.
When you took 30mg, was there no sedation at night?
That seems odd to me, but I only ever took one dose of 7.5mg at night.
Declan
Posted by xbunny on January 6, 2006, at 4:39:25
In reply to What dose of Remeron is most sedating?, posted by fachad on January 5, 2006, at 18:29:42
For me 15mg was quite sedating, 30mg less sedating and tolerable. Those are the only two doses I have tried. Buns
Posted by SandyWeb on January 6, 2006, at 8:11:37
In reply to Re: What dose of Remeron is most sedating?, posted by xbunny on January 6, 2006, at 4:39:25
I might be the exception here, but I never found Remeron to be sedating at any dose. I am taking 45 mg now, but started out at 15 mg and worked up.
My doctor had been hesitant to precribe it to me because she said it would make me "profoundly tired". I don't know why, but it just doesn't make me tired.
Sandy
Posted by fires on January 6, 2006, at 11:59:00
In reply to Re: What dose of Remeron is most sedating? » fires, posted by Declan on January 6, 2006, at 1:24:04
> Hey Fires, I'm interested.
>
> When you took 30mg, was there no sedation at night?
>
> That seems odd to me, but I only ever took one dose of 7.5mg at night.
>
> Declan
I could be wrong. It's been almost 2 years since I took it so I don't remember that much about the 30 mg dose. Also, I took it in combo. with Effexor.I'll check my med. diary to see what, if anything, I noted.
Posted by linkadge on January 6, 2006, at 16:07:32
In reply to Re: What dose of Remeron is most sedating? » Declan, posted by fires on January 6, 2006, at 11:59:00
I found it was generally more sedating upto 15mg.
But the thing is that it doesn't just magically switch from sedating to nonsedating. It is probably that the noradenergic effect overcomes the antihistamine sedation.
I found was that all doses gave a really crappy
yucky feeling to start with, but I supose I adapted to the antihistamine effect within a week or two.Linkadge
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