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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 13 to 37 of 37. Go back in thread:
Posted by ed_uk on November 19, 2005, at 16:06:43
In reply to Re: Adrafinil (Olmifon) diary - day 1 » ed_uk, posted by Meri-Tuuli on November 19, 2005, at 16:03:01
Hi Meri
>I'm glad you liked the post - I was worried after i posted that it might have caused you offense!!
LOL no :D
>I'm getting referred to a pdoc by my GP and I am SCARED!
I've seen several different pdocs and none of them were at all scary. Unfortunately, none of them were very good either!
ed x
Posted by blueberry on November 19, 2005, at 17:54:30
In reply to Adrafinil (Olmifon) diary - day 1, posted by ed_uk on November 19, 2005, at 9:10:35
I took adrafinil for over a year, so I can share a little bit of how it went. It pretty much went the way I've seen it described on the web...after two weeks you become more active and interested, after 3 weeks more talkative, after 4 weeks depression lifts...something along those lines. Different variations and different timeframes, but basically something like that.
I actually felt some mild speedish effects right from the beginning, then they faded, and then all the things described above gradually happened in a 2 to 4 week period. I was taking 600mg at first, and then after it kicked in I was able to maintain at 300mg. It never pooped out. And when I finally quit, thinking I didn't need it any more, I did a relatively fast taper compared to most meds, and there were no withdrawals. Nice.
Posted by Phillipa on November 19, 2005, at 22:41:32
In reply to Re: Adrafinil (Olmifon) diary - day 1 » ed_uk, posted by blueberry on November 19, 2005, at 17:54:30
Okay Ed what is this med? Is it only in the UK? Love PJ O
Posted by ed_uk on November 20, 2005, at 13:55:30
In reply to Re: Adrafinil (Olmifon) diary - day 1, posted by Phillipa on November 19, 2005, at 22:41:32
Hi PJ,
No, it's a French drug, similar to Provigil.
Ed xx
Posted by Declan on November 20, 2005, at 14:17:45
In reply to Re: Adrafinil (Olmifon) diary - day 1 » Phillipa, posted by ed_uk on November 20, 2005, at 13:55:30
Eddy, maybe the citalopram keeps you somewhat immune to the effects of Adrafinil. I didn't think it was subtle, although there might have been interactions (Hydergine? people say they can't notice that either). Anyway once I felt pretty bad on it. Maybe I'm med sensitive, or have heightened expectations or something.
How's it going now?
Declan
Posted by ed_uk on November 20, 2005, at 14:21:56
In reply to Re: Adrafinil (Olmifon) diary - day 1, posted by Declan on November 20, 2005, at 14:17:45
Hi Deccie
I didn't take it today because I got up late. I'm gonna start it again tomorrow and take it throughout the week. Will keep you updated!
Ed
Posted by tecknohed on November 20, 2005, at 15:59:18
In reply to Re: Adrafinil (Olmifon) diary - day 1, posted by Meri-Tuuli on November 19, 2005, at 12:01:13
Hi Meri-Tuuli,
> 'The metabolites of Adrafinil contains sulfur, and can easily be detected by a peculiar odour of the urine of the person who has taken it.'
I take modafinil and get that same odour. Maybe its something to do with the drug 'class'. One of Adrafinil's metabolites is actually modafinil itself so maybe thats it. And maybe its the modafinil that is bonded to sulfur during the breakdown/excretion process.
> Which is rather interesting. I take b-vitamins and one of them (niacin?) makes my pee bright yellow.
Buy the way, assuming you take a vitamin B 'complex', it is vitamin B2 (riboflavin) that causes the yellow urine colour rather than niacin.
Regards
teck
Posted by ed_uk on November 21, 2005, at 15:23:23
In reply to Re: Adrafinil (Olmifon) diary - day 1 » Meri-Tuuli, posted by tecknohed on November 20, 2005, at 15:59:18
Hi
Today, I took 300mg Olmifon four times a day. I'm not sure whether I noticed any effects....... probably not, although I did get a mild caffeine-like feeling at one point in the afternoon. I also felt a bit nervous, although I had quite a stressful day a work.
Ed
Posted by zeugma on November 21, 2005, at 17:01:06
In reply to Day 2/3, posted by ed_uk on November 21, 2005, at 15:23:23
hi Ed,
do you find it slows down your thoughts at all?
-z
Posted by alohashirt on November 21, 2005, at 17:13:39
In reply to Re: Adrafinil (Olmifon) diary - day 1, posted by Phillipa on November 19, 2005, at 22:41:32
> Okay Ed what is this med? Is it only in the UK? Love PJ O
Maybe someone can help clarify the legal / procedural status of this medication in the US? I know that it has never been licensed as the FDA in the US. Does this mean that it falls in the same category as a food supplement like vitamin B? Or do things that are medications in other places (e.g. anti-depressants, antibiotics) but not used in the US for market/profit reasons have a different status than herbs/vitamins/antioxidants?
My understanding is that Provigl metabolizes to Adrafinil, Provigil is patented in the US and Adrafinil isn't, Adrafinil is much cheaper, according to some a "better medication" but also has liver effects that Provigil doesn't share. A single isomer version of Provigil is coming out but I don't know if there is any medical driver for this or if its purely a profit vehicle. I have never seen Adrafinil for sale in a GNC in the US - is there a reason why? I don't want to continue this vein further and risk crossing the line of acceptable psychbabble conversations.
Some clarity here would be useful. Dr Bob - can you share anything about the legal/procedural issues surrounding meduications in this status? Are there other examples?
Posted by Nickengland on November 22, 2005, at 6:57:55
In reply to Philippa: (Re: Adrafinil (Olmifon) diary - day 1, posted by alohashirt on November 21, 2005, at 17:13:39
Hi alohashirt,
I have recently baught a food supplement - Gaba from a website which is from part of the 'yahoo/stores/shops/ Its an online company (no names mentioned*) which is American and also I baught Adrafinil from there (along with the gaba)
Package arrived - Airmail from the United states postal service from Lawrenceville GA.
I know that Adrafinil is a French smart drug, but its definitely available in the US and sold along side vitamins and supplements from my knowledge...the company I baught from has been operating since 1995.
Not sure on the legal status in the US, but yahoo don't mind having a US/online shop in their stores selling it along with vitamins etc..
Kind regards
Nick
* Not providing the webaddress due to rules etc
Posted by ed_uk on November 23, 2005, at 14:09:11
In reply to Re: Day 2/3 » ed_uk, posted by zeugma on November 21, 2005, at 17:01:06
Hi Zeugster :-)
>do you find it slows down your thoughts at all?
No - it doesn't seem to be doing anything at all ;-)
Ed
Posted by ed_uk on November 23, 2005, at 14:10:48
In reply to Re: Philippa: (Re: Adrafinil (Olmifon) diary - day 1 » alohashirt, posted by Nickengland on November 22, 2005, at 6:57:55
I'm gonna try taking 1200mg as a single dose in the morning. Will keep you up to date :-)
Ed
Posted by zeugma on November 25, 2005, at 14:56:59
In reply to Plan for tomorrow...., posted by ed_uk on November 23, 2005, at 14:10:48
Hi Ed,
No effects from 1200 mg adrafinil??
-z
Posted by ed_uk on November 26, 2005, at 13:32:53
In reply to Re: Plan for tomorrow.... » ed_uk, posted by zeugma on November 25, 2005, at 14:56:59
Hi Z
I tried 900mg but didn't notice much. I'll try 1200mg next - will report back :-)
ed
Posted by ed_uk on November 26, 2005, at 16:38:48
In reply to Re: Plan for tomorrow.... » ed_uk, posted by zeugma on November 25, 2005, at 14:56:59
Hi Z
I took 1200mg this evening. I don't think it did anything!
Ed
Posted by zeugma on November 26, 2005, at 17:17:09
In reply to Re: Plan for tomorrow.... » zeugma, posted by ed_uk on November 26, 2005, at 16:38:48
> Hi Z
>
> I took 1200mg this evening. I don't think it did anything!
>
> Edhi there Ed
hmmm. I noticed a definite effect on my cognitive processes at 50 mg of modafinil. I have no idea how much adrafinil is converted to modafinil in vivo vs. inactive metabolites. I experienced insomnia from 50-100 mg, necessitating a slow titration.
Subjects in a clinical test of a single dose of 200 mg modafinil reported a subjective increase in 'excitement.' These were subjects with adult ADHD.
I wonder how much of the difference is one between adrafinil and its not-well-known metabolism (unlike amitriptyline for example, much of adrafinil is quickly converted to inactive metabolites) and also between whatever susceptibilty you might have to the drug's effects. Saying, for instance, that a drug is a 'stimulant' is only to say that it is clinically effective in keeping about 70 percent of narcolepsy patients awake. (AD response rates also are in the 60-70 percent range.)
One investigator claims that 300 mg modafinil = 20 mg d-amphetamine in terms of wakefulness promotion. I tend to agree with this, in that it is generally accepted that methylphenidate 20 mg = 10 mg d-amphetamine, roughly, and 300 mg modafinil is somewhere between 30 mg MPH (or 15 mg d-AMPH) and 60 mg MPH in terms of duration of wakefulness induction for me.
-z
Posted by ed_uk on November 27, 2005, at 11:15:49
In reply to Re: Plan for tomorrow.... » ed_uk, posted by zeugma on November 26, 2005, at 17:17:09
Hi Z
A friend sent me ten 100mg Provigil tablets yesterday. I took 100mg this afternoon. I feel a bit jittery, a bit like I've taken some caffeine. Could be a 'placebo' effect though. I get the impression Provigil is going to be better than Olmifon. I'm starting to wonder whether I'm incapable of metabolising adrafinil to modafinil or something!
Kind regards
Ed
Posted by denise1966 on November 27, 2005, at 13:20:12
In reply to Re: Plan for tomorrow.... » zeugma, posted by ed_uk on November 27, 2005, at 11:15:49
Hi Ed,
I tried Adrafinil too and got no effects at all, can't remember the dose now.
Just wondering why you're taking it as I thought your normal regimen was working ok?
Kind Regards....Denise
Posted by ed_uk on November 27, 2005, at 14:30:52
In reply to Re: Plan for tomorrow...., posted by denise1966 on November 27, 2005, at 13:20:12
Hi Denise
I'm doing ok on citalopram 80mg but do get tired rather easily. I was hoping that adrafinil might allow me to be more alert during the day.
Ed xxx
Posted by Phillipa on November 27, 2005, at 21:26:38
In reply to Re: Plan for tomorrow.... » denise1966, posted by ed_uk on November 27, 2005, at 14:30:52
But Ed working six days a week nonstop is a lot different from being in school with breaks between subjects and weekends off not to mention you picked the times that you wanted to study. So I'd think you'd expect to be tired. Love PJ O
Posted by Bryco on November 28, 2005, at 10:59:36
In reply to Re: Plan for tomorrow.... » ed_uk, posted by Phillipa on November 27, 2005, at 21:26:38
I just took adrafinil for 1 week and stopped with it today cause it was just to bad.
The people in my class started to think i was a drug addict, my eyes were everything but normal and i just couldn't control my movements: I had VERY bad hand tremor, uncontrollable little shocks trough my body etc.
I turned into everything but nice company, not that before i took it i was nice company, but now it's even worse :-)think twice before you take it i'd suggest.(tough it seems promising when reading things about it)
now i'm going to try Sinemet if my psy agrees on it, i allready suggested it twice but i think he's to afraid of abuse, i'm 20 years old and my problems started with... yeah well.
Posted by ed_uk on November 28, 2005, at 13:18:51
In reply to !!! negative adrafinil experience !!, posted by Bryco on November 28, 2005, at 10:59:36
Today.......
I took 100mg modafinil (Provigil) four times a day. It caused a mild tremor and a mild 'buzzy' feeling. I think it made me a bit dumber than normal, I kept forgetting what I was doing and making stupid mistakes! It could have been because I didn't sleep that well last night though. I'll try it again tomorrow.
Ed
Posted by zeugma on November 28, 2005, at 18:33:47
In reply to Today I took Provigil, posted by ed_uk on November 28, 2005, at 13:18:51
> Today.......
>
> I took 100mg modafinil (Provigil) four times a day. It caused a mild tremor and a mild 'buzzy' feeling. I think it made me a bit dumber than normal, I kept forgetting what I was doing and making stupid mistakes! It could have been because I didn't sleep that well last night though. I'll try it again tomorrow.
>Hi Ed,
400 mg Provigil could very well cause insomnia (especially if you're taking it divided into four doses daily). I also found that taking 300 mg at once in the am caused overfocus, leading to various problems (not what I'd call 'stupid mistakes' but certainly not ideal directions of energy). I would imagine taking 100 mg at intervals over an eight-hour period would lead to comparable plasma levels through much of the day.
Oddly, Provigil eliminates tremors I have.
-z
Posted by ed_uk on November 30, 2005, at 15:20:31
In reply to Re: Today I took Provigil » ed_uk, posted by zeugma on November 28, 2005, at 18:33:47
Hi Z
I took 300mg today at noon. I think it made me slightly nervous. It didn't improve my attention.
>I also found that taking 300 mg at once in the am caused overfocus, leading to various problems (not what I'd call 'stupid mistakes' but certainly not ideal directions of energy).
I wasn't focussed at all - less than usual!
Kind regards
Ed
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