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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by lostforwards on October 19, 2005, at 10:36:12
I read that prozac increases norepinephrine and dopamine extracellular levels in the prefrontal cortex. Does celexa,being an SSRI, do the same thing?
Posted by Phillipa on October 19, 2005, at 19:25:50
In reply to SSRIs effects on prefrontal cortex., posted by lostforwards on October 19, 2005, at 10:36:12
I was always under the impression that prozac just worked on serotonin. And it was the first drug called an SSRI. But of course I could be wrong. Fondly, Phillipa
Posted by Shawn. T. on October 20, 2005, at 1:13:28
In reply to SSRIs effects on prefrontal cortex., posted by lostforwards on October 19, 2005, at 10:36:12
You're correct about Prozac. Celexa, being a more selective serotonin reuptake inhibitor than Prozac, does not increase extracellular norepinephrine and dopamine levels in the prefrontal cortex.
See Bymaster et al., 2002: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11919662
Shawn
Posted by Dave001 on October 23, 2005, at 14:41:38
In reply to Re: SSRIs effects on prefrontal cortex. » lostforwards, posted by Shawn. T. on October 20, 2005, at 1:13:28
> You're correct about Prozac. Celexa, being a more selective serotonin reuptake inhibitor than Prozac, does not increase extracellular norepinephrine and dopamine levels in the prefrontal cortex.
>
> See Bymaster et al., 2002: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11919662
>Address: Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285-0510, USA. F.Bymaster@Lilly.com
Is it really any wonder why Prozac accomplished what none of the other SSRIs did? ;-) Furthermore, the subjects were rats, and the significance of the results is not known.
Not that studies involving other antidepressants are funded from sources outside of industry...
This is the end of the thread.
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