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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by linkadge on July 9, 2005, at 22:07:04
Does anyone know the difference between the serotonin 5-ht1b autoreceptors and the 5-ht1b hertoreceptors?
Linkadge
Posted by bipolarspectrum on July 9, 2005, at 23:42:35
In reply to difference between heteroreceotirs and autorecepto, posted by linkadge on July 9, 2005, at 22:07:04
Link,
Whats with the indepth psychpharm questions?? I took 2 upper-year pharm courses during my undergrad and we never touches 5-ht2 heteroceptors... your gonna make a great researcher!
bps
Posted by linkadge on July 9, 2005, at 23:53:46
In reply to Re: difference between heteroreceotirs and autorecepto, posted by bipolarspectrum on July 9, 2005, at 23:42:35
I was just reading an article on the effects of fasting and exercise on the 5-ht1b autoreceptors. I kind of understand what the autoreceptors do, but was not sure about the actions of the heteroreceptors.
Linkadge
Posted by Shawn. T. on July 10, 2005, at 6:14:15
In reply to difference between heteroreceotirs and autorecepto, posted by linkadge on July 9, 2005, at 22:07:04
A 5-HT1B autoreceptor decreases the synthesis & release of serotonin. A 5-HT1B heteroreceptor decreases the synthesis & release of some other neurotransmitter or neuromodulator. 5-HT1A receptors are autoreceptors on cell bodies or dendrites. 5-HT1B and 5-HT1D are autoreceptors at axon terminals. Full agonists can desensitize these receptors after chronic use, resulting in a decreased effect upon synthesis/release. Partial agonists cause less desensitization and therefore may decrease synthesis/release to a greater degree than full agonists when chronically administered.
Shawn
Posted by linkadge on July 10, 2005, at 15:34:08
In reply to Re: difference between auto- and heteroreceptors, posted by Shawn. T. on July 10, 2005, at 6:14:15
Am I correct in my understanding that lithium antagonizes the 1b autoreceptor and hence leading to greater serotonin synthesis and release?
Or is the heteroreceptor involved?
Linkadge
Posted by Shawn. T. on July 11, 2005, at 14:00:45
In reply to Re: difference between auto- and heteroreceptors, posted by linkadge on July 10, 2005, at 15:34:08
>Am I correct in my understanding that lithium >antagonizes the 1b autoreceptor and hence >leading to greater serotonin synthesis and >release?
That's correct. Lithium only increases serotonin release in certain areas of the brain, so keep that in mind.
Shawn
Posted by linkadge on July 12, 2005, at 20:00:37
In reply to Re: difference between auto- and heteroreceptors, posted by Shawn. T. on July 11, 2005, at 14:00:45
Why do the autoreceptors become so sensitive?
Is it really a result of decreased synaptic serotonin or is it something else that leads to supersensitive autoreceptors.
Linkadge
Posted by Shawn. T. on July 14, 2005, at 19:34:17
In reply to Re: difference between auto- and heteroreceptors, posted by linkadge on July 12, 2005, at 20:00:37
Persistent agonist activity at an autoreceptor can result in a decrease in the amount of membrane-associated G(alpha)i. G(alpha)i inhibits adenylate cyclase, an enzyme that catalyzes the formation of cyclic AMP (cAMP) from ATP. Persistent agonist activity at G(alpha)i coupled receptors may also result in a sensitization of adenylate cyclase, which would lead to an increase in cAMP formation. The mechanisms involved are more complicated than that, and they still aren't fully understood yet. Decreased extracellular serotonin levels can increase the sensitivity of serotonin autoreceptors.
Shawn
This is the end of the thread.
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