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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on July 9, 2005, at 22:14:49
The following study suggests melancholy might be associated with decreased sensitivity of 5-ht1d receptor, and that SSRI's don't ameliorate this.
SSRI apathy.
Any 5-ht1d receptor antagonists out there ?
http://bjp.rcpsych.org/cgi/content/full/178/5/454
Linkadge
Posted by linkadge on July 9, 2005, at 22:55:01
In reply to 5-ht1d melancholy and SSRI's, posted by linkadge on July 9, 2005, at 22:14:49
Perhaps if you have major depression without OCD, then SSRI's might not be best. 5-ht1d stimulation seems to have apathy promoting/anti-ocd properties.
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Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.
J Clin Psychiatry. 2004;65 Suppl 1418-21.
Support for the serotonin-1D (5-HT(1D)) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT(1D) agonist sumatriptan, and case reports in which prolonged administration of 5-HT(1D) agonists was associated with a therapeutic effect, suggest that 5-HT(1D) may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT(1D) gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT(1D) hypothesis requires further investigation in order to disentangle the role of the 5-HT(1D) receptor in this common and often severe disorder. [Abstract]
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