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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by TrishP on April 14, 2005, at 6:52:27
Will taking an antiepileptic like Trileptal or Zonegran help reduce the risk of having a seizure while taking Wellbutrin? I recently went up from 150mg of Wellbutrin to 200mg. I know this is still a small dose, but I'm still nervous about the seizure thing.
I'm moving from Trileptal to Zonegran for mood. Will this help reduce my seizure risk?
Posted by lunesta on April 14, 2005, at 8:09:14
In reply to Reduce Seizure Risk?, posted by TrishP on April 14, 2005, at 6:52:27
yes. those are there purpose!
Posted by Maxime on April 14, 2005, at 12:43:37
In reply to Reduce Seizure Risk?, posted by TrishP on April 14, 2005, at 6:52:27
Is Zonegran known to help moods?
Maxime
> Will taking an antiepileptic like Trileptal or Zonegran help reduce the risk of having a seizure while taking Wellbutrin? I recently went up from 150mg of Wellbutrin to 200mg. I know this is still a small dose, but I'm still nervous about the seizure thing.
>
> I'm moving from Trileptal to Zonegran for mood. Will this help reduce my seizure risk?
Posted by ed_uk on April 14, 2005, at 12:48:12
In reply to Re: Reduce Seizure Risk? » TrishP, posted by Maxime on April 14, 2005, at 12:43:37
Hi!
J Clin Psychiatry. 2005 Feb;66(2):195-8.
A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients.Anand A, Bukhari L, Jennings SA, Lee C, Kamat M, Shekhar A, Nurnberger JI Jr, Lightfoot J.
Department of Psychiatry, Indiana University School of Medicine, IN 46202, USA. aanand@iupui.edu
OBJECTIVE: The purpose of this study was to investigate the effectiveness of zonisamide in the treatment of bipolar depression. METHOD: Ten patients with DSM-IV bipolar disorder, depressed phase, who had either not tolerated or not responded to previous treatments were given zonisamide in this add-on open-label study. Zonisamide treatment was started at 100 mg/day and increased by 100 mg every 2 weeks to a maximum of 300 mg/day in divided doses (b.i.d. or t.i.d.). Subjects underwent weekly visits at which they were administered the 17-item Hamilton Rating Scale for Depression (HAM-D), Young Mania Rating Scale (YMRS), and Clinical Global Impressions scale (CGI). Every 2 weeks, subjects also underwent laboratory tests, a urine examination, and a verbal memory test. Outcome measures were analyzed with repeated-measures analysis of variance. RESULTS: Eight subjects completed all 8 weeks of the study. Two subjects completed more than 4 weeks of the study, and their data were analyzed using the last observation carried forward. Bipolar depression subjects had a significant reduction in HAM-D scores (p < .001) and in CGI-Improvement (CGI-I) scores (p < .001). Five of 8 subjects who completed all 8 weeks of the study had more than a 50% decrease in HAM-D scores and were rated much improved on the CGI-I at the end of 8 weeks of treatment. There was no significant drug effect on YMRS scores, weight, or verbal memory. CONCLUSION: Zonisamide may be a useful drug in the treatment of bipolar depression. Further controlled clinical trials are needed.
Ed xxxxxx
Posted by temoigneur on April 14, 2005, at 17:59:34
In reply to Re: Reduce Seizure Risk? » Maxime, posted by ed_uk on April 14, 2005, at 12:48:12
Hi Ed - howz it going? I wanted to ask you about your situation, and if I might, what your on that's seemingly allowing you to function. i was wondering, how you feel, and maybe about past experiences with meds. I apologize, I wrote you at your 'home' address, but perhaps it would have been better to send it through babble mail - this was after you sent the msg 'I only just now got your email'!
You're case intrigues me b/c we do have similarities, well i imagine a great number on this board do- considering the relatively limited spectrum of medications used to treat the full gammit of psychiatric disorders. I was really sorry to read this about Lunesta. I couldn't imagine how it would be any different from zopiclone, (I'm canadian) - but with the all the hype, and not having seen any talk of cross tolerance with benzo's or the like I had hopes. :(
Re: clomipramine and sedation - I still feel like my creativity has been partially zapped, I'm thinking I might want to titrate slightly lower but we'll see.
Well, it looks like I may be getting into one of the finest pdocs in Vancouver, - I'm told he knows his meds, this would be amazing. Please feel free to email me at my home address, also do you check your 'home' addy, I would send this there, Take Care
Ben
Posted by Maxime on April 14, 2005, at 20:53:15
In reply to Re: Reduce Seizure Risk? » Maxime, posted by ed_uk on April 14, 2005, at 12:48:12
Hi Ed. It's not available in Canada though.
xxxx
Maxime
> Hi!
>
> J Clin Psychiatry. 2005 Feb;66(2):195-8.
>
> A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients.
>
> Anand A, Bukhari L, Jennings SA, Lee C, Kamat M, Shekhar A, Nurnberger JI Jr, Lightfoot J.
>
> Department of Psychiatry, Indiana University School of Medicine, IN 46202, USA. aanand@iupui.edu
>
> OBJECTIVE: The purpose of this study was to investigate the effectiveness of zonisamide in the treatment of bipolar depression. METHOD: Ten patients with DSM-IV bipolar disorder, depressed phase, who had either not tolerated or not responded to previous treatments were given zonisamide in this add-on open-label study. Zonisamide treatment was started at 100 mg/day and increased by 100 mg every 2 weeks to a maximum of 300 mg/day in divided doses (b.i.d. or t.i.d.). Subjects underwent weekly visits at which they were administered the 17-item Hamilton Rating Scale for Depression (HAM-D), Young Mania Rating Scale (YMRS), and Clinical Global Impressions scale (CGI). Every 2 weeks, subjects also underwent laboratory tests, a urine examination, and a verbal memory test. Outcome measures were analyzed with repeated-measures analysis of variance. RESULTS: Eight subjects completed all 8 weeks of the study. Two subjects completed more than 4 weeks of the study, and their data were analyzed using the last observation carried forward. Bipolar depression subjects had a significant reduction in HAM-D scores (p < .001) and in CGI-Improvement (CGI-I) scores (p < .001). Five of 8 subjects who completed all 8 weeks of the study had more than a 50% decrease in HAM-D scores and were rated much improved on the CGI-I at the end of 8 weeks of treatment. There was no significant drug effect on YMRS scores, weight, or verbal memory. CONCLUSION: Zonisamide may be a useful drug in the treatment of bipolar depression. Further controlled clinical trials are needed.
>
> Ed xxxxxx
Posted by ed_uk on April 16, 2005, at 15:07:57
In reply to Re: Reduce Seizure Risk? » ed_uk, posted by Maxime on April 14, 2005, at 20:53:15
Hi Maxi!
It's not available here either!
Ed xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
This is the end of the thread.
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