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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by sdb on April 10, 2005, at 12:39:49
Does somebody have experience with alpha2-agonists like (clonodine...) to combat central over-noradrenaline transmission?
And is there somebody with parasympathomimetica experience?
I have found an interesting article for biochemical reasons of social phobia:
It is written
"While normal beta-adrenergic receptor number was observed in lymphocytes, a blunted response of growth hormone to clonidine, an a2-adrenergic agonist, was reported. This suggests reduced post-synaptic a2-adrenergic receptor functioning related to norepinephrine overactivity in social phobia. "
But in this article are more possible explanations, so there is obviously no ultimative trigger for social phobia (I personally suppose that individuals could have genetically and biochemically more responsiveness for sp, but i dont think there is a soul trigger organically).
Link
Pmid: 15538306
Posted by The_Resistance on April 10, 2005, at 15:13:18
In reply to alpha2-agonists and parasympathomimetica, posted by sdb on April 10, 2005, at 12:39:49
All the research on Social Anxiety is interesting.
Its difficult to translate the research in usefull stratergies (for me at least!)
I have never tried Clonodine, but apparently it can exacibate depression.
Posted by Phillipa on April 10, 2005, at 17:17:05
In reply to Re: alpha2-agonists and parasympathomimetica, posted by The_Resistance on April 10, 2005, at 15:13:18
Posted by sdb on April 10, 2005, at 17:19:56
In reply to Re: alpha2-agonists and parasympathomimetica (nm), posted by Phillipa on April 10, 2005, at 17:17:05
What does that mean Phillipa, (nm)
Kind regards
sdb
Posted by sdb on April 10, 2005, at 17:26:18
In reply to Re: alpha2-agonists and parasympathomimetica, posted by sdb on April 10, 2005, at 17:19:56
NM - Nautical Mile
NM - Network Module
NM - New Mexico
NM - Night Message
NM - nitro methane
+ NO2-CH3
NM - nitrosomesitylene
+ 1,3,5-(CH3)3-2-(O=N)-C6H2
+ 1,3,5-trimethyl-2-nitroso benzene
NM - No Mark
+ Not Marked????
I am weary of working and must go to bed.
Good night
Posted by Phillipa on April 10, 2005, at 18:00:24
In reply to Re: alpha2-agonists and parasympathomimetica, posted by sdb on April 10, 2005, at 17:19:56
It means I'm an idiot and don't know what you're talking about but would like to learn. So instead of posting something that wouldn't contribute to what you're asking I wanted to follow the Thread. I hope you're not mad? Fondly, Phillipa
Posted by sdb on April 10, 2005, at 18:50:42
In reply to Re: alpha2-agonists and parasympathomimetica » sdb, posted by Phillipa on April 10, 2005, at 18:00:24
Dear Phillipa,
You are definately not an idiot! You are a precious human being with many talents or probably hidden talents and you are person, who wants to learn.
alpha2-agonists decrease noradrenergic central (in the brain )transmission. This could be usefull for people with anxiety problems. It reduces adrenal response to stress.
Unfortunately this could be lead to depression for some persons because central noradrenaline has activating properties which is important when your not to much stressed.
But I have the alpha2-agonist not taken yet, so I can probably tell you some weeks or months later about some experiences.
Fondly,
sdb
Posted by Iansf on April 10, 2005, at 22:06:22
In reply to alpha2-agonists and parasympathomimetica, posted by sdb on April 10, 2005, at 12:39:49
Can someone translate please:
> I have found an interesting article for biochemical reasons of social phobia:
>
> It is written
>
> "While normal beta-adrenergic receptor number was observed in lymphocytes, a blunted response of growth hormone to clonidine, an a2-adrenergic agonist, was reported. This suggests reduced post-synaptic a2-adrenergic receptor functioning related to norepinephrine overactivity in social phobia. "
>
> But in this article are more possible explanations, so there is obviously no ultimative trigger for social phobia (I personally suppose that individuals could have genetically and biochemically more responsiveness for sp, but i dont think there is a soul trigger organically).
>
> Link
>
> Pmid: 15538306
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15538306
Posted by SLS on April 11, 2005, at 7:20:42
In reply to alpha2-agonists and parasympathomimetica, posted by sdb on April 10, 2005, at 12:39:49
> Does somebody have experience with alpha2-agonists like (clonodine...) to combat central over-noradrenaline transmission?
>
> And is there somebody with parasympathomimetica experience?
Are you experiencing dysautonomia?As someone suggested, clonidine can be depressogenic, even in otherwise mentally healthy people. Still, I don't think this would be sufficient reason not to try it.
- Scott
Posted by sdb on April 11, 2005, at 10:20:03
In reply to Re: alpha2-agonists and parasympathomimetica » sdb, posted by SLS on April 11, 2005, at 7:20:42
Have you taken it?
It could be used for specific phobias or as a supplement to an other activating drug.
Posted by seamus2 on April 11, 2005, at 10:35:18
In reply to Re: alpha2-agonists and parasympathomimetica, posted by sdb on April 11, 2005, at 10:20:03
If you view social-phobia as an exaggerated "fight or flight" response, systematic desensitization w/ the concomittant use of Inderal might be worth a try.
Posted by ed_uk on April 11, 2005, at 11:28:54
In reply to Re: alpha2-agonists and parasympathomimetica, posted by sdb on April 10, 2005, at 18:50:42
Hi!!!
>You are a precious human being with many talents or probably hidden talents and you are person, who wants to learn.
Awww sdb! That was a really nice thing to say! You are right, Phillipa is lovely and very talented- she was an excellent nurse :-)
Kind regards,
Ed.
Posted by Phillipa on April 11, 2005, at 15:50:45
In reply to To sdb and Phillipa » sdb, posted by ed_uk on April 11, 2005, at 11:28:54
Ed, You are sooooo sweet! Thanks for the compliment. Maybe I will be able to go back to nursing someday. Who knows? Fondly, Phillipa OOOO
Posted by sdb on April 11, 2005, at 15:57:07
In reply to Re: alpha2-agonists and parasympathomimetica, posted by seamus2 on April 11, 2005, at 10:35:18
I think social phobia can not be treatet as well as depression today. Reasons for Social phobia are very difficult to find biologically. The alpha2-agonist is, as stated in the article, only one explanation how something could be treated. The brain is complex, there are different cells in different locations with different ligands. It is clear that for example also things like early "mobbing" in school could lead to sp. People seems to be more or less sensitive to sp and its similar with other mental illnesses. But why the sensitivity for social phobia? I dont know, if it could be only hereditary. Unipolar, bipolar depression definitaly can. But i dont know with sp and ocd.
Posted by Spriggy on April 11, 2005, at 16:22:10
In reply to To sdb and Phillipa » sdb, posted by ed_uk on April 11, 2005, at 11:28:54
This is the end of the thread.
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