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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by ed_uk on February 16, 2005, at 9:42:23
Fluoxetine (Prozac) and paroxetine (Seroxat, Paxil) are inhibitors of CYP2D6.
From a UK government report....
It has recently been shown that CYP2D6 is involved in the metabolism of endogenous
amines that may be precursors of neurotransmitters such as dopamine. Theoretically, in extensive metabolisers of CYP2D6, drug administration may lead to inhibition of this P450 isoform with a consequent effect on endogenous metabolites, possibly leading to a relative deficiency of catecholamines in crucial areas of the brain. The relevance of this with respect to underlying personality, psychiatric disease and the pharmacology of the drugs used to treat these diseases is unclear and needs further investigation.Yu AM, Idle JR, Herraiz T, Kupfer A, Gonzalez FJ. Screening for endogenous
substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.
Pharmacogenetics 2003;13(6):307-19.Yu AM, Idle JR, Gonzalez FJ. Polymorphic cytochrome P450 2D6: humanized
mouse model and endogenous substrates. Drug Metabolism Reviews
2004;36(2):243-77.Ed.
Posted by Nixon on February 16, 2005, at 10:00:27
In reply to SSRIs and possible catecholamine depletion, posted by ed_uk on February 16, 2005, at 9:42:23
Hey Ed,
Just stopped by and saw this. Interesting stuff. So the ramifications of taking Prozac as I do could be negative? Hmmm. I did not start the valium yet, I thought I would wait till Friday after I get home from work. I'll take a dose of librium thursday pm as usual and hold off for the valium till Friday around 6pm. I posted about anyone with experiences with Prozac Weekly and no responses, oh well. Instead I see a post under this about someone who is a wizard. Whatever. JN
Posted by bart on February 16, 2005, at 10:21:27
In reply to SSRIs and possible catecholamine depletion, posted by ed_uk on February 16, 2005, at 9:42:23
Yes indeed. I'm starting to read and hear a lot of things on that subject. From my own experience it makes a lot of sense. I think that subject matter could be one of the culprits for why SSRI's lose effectiveness over time for some people and cause a lot of fogginess and apathy
Posted by soft on February 16, 2005, at 16:00:57
In reply to SSRIs and possible catecholamine depletion, posted by ed_uk on February 16, 2005, at 9:42:23
Certain foods can increase catecholamine levels including coffee, tea, bananas, chocolate, cocoa, citrus fruits, and vanilla.
Posted by Phillipa on February 16, 2005, at 18:21:17
In reply to Re: SSRIs and possible catecholamine depletion, posted by soft on February 16, 2005, at 16:00:57
So, does zoloft and remeron fit this picture too? I just don't have a brain that absorbs this type of info, and can put it to use. Fondly, Phillipa Does this include TCA's too?
Posted by Minnie-Haha on February 16, 2005, at 18:34:02
In reply to Re: SSRIs and possible catecholamine depletion, posted by Phillipa on February 16, 2005, at 18:21:17
Yeah... What does this MEAN? For whom among us does this have implications?
Posted by MM on February 17, 2005, at 20:59:13
In reply to SSRIs and possible catecholamine depletion, posted by ed_uk on February 16, 2005, at 9:42:23
Posted by sabre on February 18, 2005, at 22:47:59
In reply to SSRIs and possible catecholamine depletion, posted by ed_uk on February 16, 2005, at 9:42:23
Hi Ed
Does this only apply to Paxil and Prozac? Any other SSRIs?
So if you are already deficient in NA or DA, these drugs might not be a good idea?
Thanks
sabre
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