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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by ace on January 7, 2005, at 20:51:05
Hi dudes and dudettes....
i am a fat man. quite a tubby man indeed! This is Zyprexa's fault: even though it has helped my OCD greatly
who has been on seroquel and zyprexa, and what is the weight gain contrast between the two???
Fat man Ace!
Posted by zero on January 8, 2005, at 0:42:38
In reply to SEROQUEL VS ZYPREXA: WEIGHT GAIN...., posted by ace on January 7, 2005, at 20:51:05
ace,
this is worth a look if you've never seen it (esp. the bottom section specific to methods of counteracting Zyprexa induced weight gain):http://www.psycheducation.org/hormones/Insulin/weightgain.htm
hope it's helpful.
z.
Posted by Kenny Koala on January 8, 2005, at 7:04:02
In reply to Re: SEROQUEL VS ZYPREXA: WEIGHT GAIN...., posted by zero on January 8, 2005, at 0:42:38
It's not what you asked for, but maybe useful.
http://www.nimh.nih.gov/ncdeu/abstracts2001/ncdeu3080.cfm
Concomitant Use of Trazodone May Attenuate Olanzapine-Associated Weight Gain Olanzapine, Weight Gain, Trazodone, mCPP, Serotonin
George E Jaskiw 1; E-mail: gxj5@po.cwru.edu1 Louis Stokes Cleveland VAMC
Introduction: Olanzapine-associated weight gain is a significant adverse event that may lead to obesity-related health risks and poor medication compliance. The precise mechanisms underlying the weight gain are not known. It is possible that at least some of the weight gain may be mediated through olanzapine's antagonist actions on the 5-HT2C receptor. The latter has been implicated in the regulation of weight and satiety in both human and animal studies. mCPP, the primary metabolite of trazodone, is a potent agonist at the 5-HT2C receptor. Pharmacologically relevant plasma levels of mCPP are generated during treatment with trazodone. We posited that trazodone co-administered with olanzapine would reduce olanzapine-associated weight gain.
Methods: Ours was a retrospective chart review of weight changes in several groups of patients; A) patients treated with olanzapine alone (n=14), B) trazodone treatment initiated before olanzapine therapy (n=33), C) olanzapine treatment initiated before trazodone treatment (n=10).
Results: Patients taking olanzapine alone (Group A) gained a mean weight of 15.50+/- 12.46 lbs. over a course of 8.6 months (p<0.001). Patients treated with trazodone and then started on olanzapine (Group B), gained 5.21+/- 14.09lbs (p=0.02). The difference in weight gain between groups A and B was statistically significant (p < 0.002). Patients treated with olanzapine and subsequently started on trazodone (Group C) lost 5.78+/-11.51 lbs (NS).
Conclusions: The data suggest that concomitant treatment with trazodone may attenuate olanzapine-associated weight gain.
Significance: This study is compatible with the hypothesis that 5-HT2C antagonist actions may contribute to atypical antipsychotic-induced weight gain and that the latter may be attenuated by concomitant treatment with a 5-HT2C agonist. Prevention of weight gain could reduce long-term medical morbidity and improve medication compliance in patients taking olanzapine and other atypical antipsychotic drugs.
KK.
Posted by Camille Dumont on January 8, 2005, at 11:42:13
In reply to SEROQUEL VS ZYPREXA: WEIGHT GAIN...., posted by ace on January 7, 2005, at 20:51:05
Well, zyprexa made me gain weight whereas seroquel made me lose weight.
With Seroquel I went from 115 pounds (usual weight) to 105 in a couple of weeks. With Zyprexa in less than two weeks I went from 105 to 117 pounds but I stopped taking it because a) didn't want the weight gain and b) it gave me seizures.
But my experience might not be representative because I'm one of those weird people who tend to lose weight on most ADs
Posted by TomG on January 8, 2005, at 12:04:31
In reply to Re: SEROQUEL VS ZYPREXA: WEIGHT GAIN...., posted by Camille Dumont on January 8, 2005, at 11:42:13
ace, If its any help I lost about 12lbs. while taking Geodon. I've since stopped taking it, but I think the weight would have kept going if I had kept taking it. Zyprexa also made me gain about 25lbs. Geodon may not be available in Austrailia. I'm not sure about that one.
Posted by Tepiaca on January 8, 2005, at 12:50:47
In reply to SEROQUEL VS ZYPREXA: WEIGHT GAIN...., posted by ace on January 7, 2005, at 20:51:05
> Hi dudes and dudettes....
>
> i am a fat man. quite a tubby man indeed! This is Zyprexa's fault: even though it has helped my OCD greatly
>
> who has been on seroquel and zyprexa, and what is the weight gain contrast between the two???
>
>
> Fat man Ace!In my experience , as you know champion , Zyprexa made me gain a lot of weight.
With Seroquel I gained no weight in 2 years no matter the dose.
tep
Posted by ace on January 10, 2005, at 22:15:46
In reply to Re: SEROQUEL VS ZYPREXA: WEIGHT GAIN...., posted by TomG on January 8, 2005, at 12:04:31
This is the end of the thread.
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