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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by KaraS on January 7, 2005, at 15:11:05
Does anyone know if this would also be the standard two weeks?
Posted by Maxime on January 7, 2005, at 20:40:23
In reply to Washout time from SJW before starting on MAOI?, posted by KaraS on January 7, 2005, at 15:11:05
To be safe, yes. The thing about herbal remedies is you don't really know how much of the active ingredient is in there.
You can ask your doctor.
Max
Posted by KaraS on January 7, 2005, at 21:47:00
In reply to Re: Washout time from SJW before starting on MAOI?, posted by Maxime on January 7, 2005, at 20:40:23
> To be safe, yes. The thing about herbal remedies is you don't really know how much of the active ingredient is in there.
>
> You can ask your doctor.
>
> MaxThanks. From what I've been reading, it seems to have a half-life more in line with Prozac's. So I'm thinking (unfortunately) that a 5 week washout is probably necessary.
K
Posted by djmmm on January 7, 2005, at 22:06:58
In reply to Re: Washout time from SJW before starting on MAOI? » Maxime, posted by KaraS on January 7, 2005, at 21:47:00
> > To be safe, yes. The thing about herbal remedies is you don't really know how much of the active ingredient is in there.
> >
> > You can ask your doctor.
> >
> > Max
>
> Thanks. From what I've been reading, it seems to have a half-life more in line with Prozac's. So I'm thinking (unfortunately) that a 5 week washout is probably necessary.
>
> KHonestly..there is really no need for a significant washout period, a couple of days should be fine. I switched from Nardil to Parnate without a washout period, and a there is little evidence that SJW has any signifcant effect on monoamines or acts as a MAOI.
Posted by Larry Hoover on January 7, 2005, at 22:22:16
In reply to Washout time from SJW before starting on MAOI?, posted by KaraS on January 7, 2005, at 15:11:05
> Does anyone know if this would also be the standard two weeks?
I know there are multiple active principles to consider, but the 300 mg t.i.d. dose schedule suggests an eight hour half life. Three days ought to do it.
OK, I went to Pubmed. The half-life of hyperforin is less than three hours. The half-life for hypericin is 24 hours. Six days, and you're at near undetectable of both of these principle active ingredients.
Lar
Posted by KaraS on January 7, 2005, at 22:44:41
In reply to Washout time from SJW before starting on MAOI?, posted by KaraS on January 7, 2005, at 15:11:05
This is the end of the thread.
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