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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Willyee on December 9, 2004, at 2:25:07
I have to say i was really disapointed i did not get any response to the post below which i left a few days ago.At the very least i was really hoping a few people would not mind simply sharing the dosage amount of parnate they take,as far as the max taken in a single dosing.
I range anywhere from 20mg at a dosing,to 40 mg which i never go above.
30mg seems to be the more common dose for me.I also find unless its after a larger amout has been consumed,i can not tolerate a 10mg dosing of parnate,it agiates me.I know the post is long,but i will try asking one more time,can anyone share with me the amount of parnate they take in a single setting.Thank you!
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I want to first say i find it very comforting to find a place where there are so many Maoi users.Localy the average person,and most docters are totaly unfamiliar with them,they just know of the common ssris,so i have no one to share infromation with in real time.I say im on parnate and people give me a blank stare.I also wanna state that a recent thread about parnate had me in awe as it sounded like the words were comming right from my mouth.
Parnate now is still providing me stableness,and being on all the other meds numerous times i have no intention on going back.I like the other poster however crave the initial relief parnate provided me with during its first year.The incosistnency of the med right now is driving me crazy,i have augmented it with tons of substances from meds to herbs.
Currently im finding most benifit from 3 caps of l-thenaine,.25 klonopin,partial tab of vivarin,20-30 mg parnate.
There is a initial discomfort as it settles,but after i am able to be fully funciontal and racing thoughts stop.
The caffiene from what i read is a smooth muscle relaxant at low doses which is why i think it helps,i now wont even consider taking parnate with out even a small pieace of it.
I guess the previous poster already asked the question on any possable recomendations on add-ons,so i will be sure to keep my eye out on any posts,and will keep everyone updated on my progress as well.
As far as nardil goes,i understand it has a slight gaba effect that parnate doesent,but i also heard a major believe of its therputic action is the fact a metabolite of it turns into PEA the feel good choclate substance,which may explain whynardil users tend to like chocalte.
Im curious if parnate has the same effect on PEA.Has anyone heard of this?
Also i am very very curious to know others dosing amounts.Id greatly appreciate anyone to share,i myself will dose no higher than 40 mg at a time,but 30-20 mg is much much more common.
Can someone please share the amount of parnate they take in a single dosing?please!
I ask this also because what i notice is i can only tolerate a 10 mg dose of parnate if i had already had a larger dose earlier,a single 10 mg dose puts me in a very bad mood.I also am not able to take parnate alone anymore,i have to augment it,anyone else have this problem as well?
I am very very sorry to drop so many questions at once,please feel free to answer any one of them,as they all are very important to me and information on even a single question would greatly be appreciated.
(Ill be sure to keep everyone updated to my -----parnate trials,thank you for the ear!
Posted by ed_uk on December 9, 2004, at 5:14:47
In reply to Parnate again.., posted by Willyee on December 9, 2004, at 2:25:07
Hi Willyee,
I just wanted to say hello. Try not to be upset that no one answered your post, babble seems to be rather quiet lately, I think a lot of people are either quite depressed at the moment or busy with work. Unfortunately, I can't answer your question about Parnate dosing because I've never taken Parnate.
Regards,
Ed.
Posted by SLS on December 9, 2004, at 6:57:19
In reply to Parnate again.., posted by Willyee on December 9, 2004, at 2:25:07
Hey there.
Sorry I did't repond to your initial post, but I've been feeling very low lately. I used to take Parnate at dosages as high as 120mg. I took 40mg three times a day and never had a problem with it. When I was at 80mg, I took 40mg upon awakening and 40mg in the early afternoon.
Be well.
- Scott
Posted by ed_uk on December 9, 2004, at 7:02:15
In reply to Re: Parnate again.. » Willyee, posted by SLS on December 9, 2004, at 6:57:19
Hi Scott,
Are you thinking of trying Parnate again, maybe in combination with some of the drugs that you're taking at the moment?
Regards,
Ed.
Posted by SDW on December 9, 2004, at 10:00:15
In reply to Re: Parnate again.. » SLS, posted by ed_uk on December 9, 2004, at 7:02:15
I just restared Parnate after a 5-month break to see if I can get it to work again at a higher dose. I had been taking 60 mg (30/30) and this became ineffective. Now I am at 90 mg and I take (30/30/30). I may go as high as 120mg before I give up and move on. It's one of the best AD's there is, until it quits on you.
Posted by libbyann on December 9, 2004, at 10:09:06
In reply to Re: Parnate again.., posted by SDW on December 9, 2004, at 10:00:15
I would gladly reply, but I don't know what Parnate is. I'm on Paxil and Klonopin for GAD. I've taken Prozac, Effexor, Buspar, Lexapro, Gabitril, and Zyprexa. :) If you have questions about any of those, my thoughts are always free!!
libbyann
Posted by Dan Perkins on December 9, 2004, at 10:21:10
In reply to Parnate again.., posted by Willyee on December 9, 2004, at 2:25:07
Hi,
I went as high as 90mg but found that 70mg was best for me. I actually got more depressed if I went above 70mg.
I also took all 70mg as a single dose in the morning. I tried splitting up the dose, but found that a single morning dose worked best for me.
Posted by SLS on December 9, 2004, at 11:06:10
In reply to Re: Parnate again.. » SLS, posted by ed_uk on December 9, 2004, at 7:02:15
> Are you thinking of trying Parnate again, maybe in combination with some of the drugs that you're taking at the moment?
Hi Ed.
I am in the middle of a decision making process that I am having difficulty with. I can either add Parnate to what I am already taking, undergo a trial of mifepristone, or give rTMS a try. Parnate + desipramine was the only thing I responded well to. Unfortunately, Parnate + TCA no longer works. At best, it takes the edge off the depression. Otherwise, it really represents a dead end. The only thing novel to me would be that I am now taking Abilify. I really don't think that it will make any difference, though.
Any thoughts?
Thanks.
- Scott
Posted by ed_uk on December 9, 2004, at 11:35:51
In reply to Re: Parnate again.. » ed_uk, posted by SLS on December 9, 2004, at 11:06:10
Hi,
What do you think about trying a higher dose of Parnate? (like Chairman_MAO)
Ed.
Posted by ed_uk on December 9, 2004, at 11:44:17
In reply to Re: Parnate again.. » SLS, posted by ed_uk on December 9, 2004, at 11:35:51
.... apparantly, one woman who was taking 600mg Parnate a day developed severe thrombocytopenia!
Ed.
Posted by Willyee on December 10, 2004, at 0:34:47
In reply to Re: Parnate again.., posted by ed_uk on December 9, 2004, at 11:44:17
> .... apparantly, one woman who was taking 600mg Parnate a day developed severe thrombocytopenia!
>
> Ed.Thank you very much guys,i greatly appreciate the responses.I am still on the med,the only possable switch would be to nardil,i had a quick unsussesful run at it before but having tried everything else numerous times nardil would be the only one worth considering again.I think i will first continue to to augmen the parnate or go higher,i thought i was a freak dosing at 40 mg but i see one poster doses at 70 mg,so i guess it depends on the individual.
I have contacted the company,and they have little to no information on their product parnate,so the date sheet recomendations as far as max dosage were set with little investigation,in fact one sheet recomends no higher than 30 while a newer one alows up to 60mg,what this tellls me is that the med was so short lived througough examination of it was never truly accomplished.Calling the company was a huge dissapoint they had zero info and read from the same sheets i had,so i guess using the med cautisoluy is and sharing info is the best way,im still in awe one is able to handle a 70 mg dose,kuddos to you lol.Unfortunatly the med is loosing its effectinniess for me by the day i will take into consderation several of the options u guys left for me,thanks once again.
Posted by SLS on December 10, 2004, at 8:30:54
In reply to Re: Parnate again.. » SLS, posted by ed_uk on December 9, 2004, at 11:35:51
> Hi,
>
> What do you think about trying a higher dose of Parnate? (like Chairman_MAO)
>
> Ed.
Hi Ed.That's a great suggestion. I don't know how high "high" is. I have tried dosages between 120-150mg. I gleaned cognitive improvements at that dosage that I didn't have at lower dosages. It was one of the few times in the last 14 years that I could actually read, learn, and remember. How does one go about determining the maximum dosage for any one individual? I know that a few people have been to 200mg and perhaps as much as 300mg. What do you think?
Thanks.
- Scott
Posted by ed_uk on December 10, 2004, at 9:20:52
In reply to Re: Parnate again.., posted by SLS on December 10, 2004, at 8:30:54
Hi Scott,
I don't know of any way to determine what dose would be too high apart from trial and error. As far as I know, doses as high as you've already taken haven't really been studied. It would make sense to monitor your platelet count at high doses because of the numerous reports of thrombocytopenia.
Some people tolerate high doses a little too well!
Br J Psychiatry. 1991 Jun;158:856-7.
Dependence on monoamine oxidase inhibitors in high dose.
Vartzopoulos D, Krull F.
Universitats-Nervenklinik, Koln.A 37-year-old woman with a personality disorder and chronic dysthymia developed a dependence on MAOIs. She ingested 440 mg tranylcypromine daily without any side-effects while taking no dietary precautions.
Regards,
Ed.
Posted by Dan Perkins on December 10, 2004, at 13:58:55
In reply to Re: Parnate again.. » SLS, posted by ed_uk on December 10, 2004, at 9:20:52
I would agree that trial and error with careful monitoring is the only way to determine the right Parnate dose for you. For me, 70mg was the right dose, I would get more depressed if I took more or less than this amount.
This is the end of the thread.
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