Psycho-Babble Medication Thread 411390

Shown: posts 1 to 5 of 5. This is the beginning of the thread.

 

Gepirone

Posted by Iansf on November 3, 2004, at 23:21:44

Does anyone know why Gepirone was not approved by the FDA? I came across multiple studies demonstrating its effectiveness, but I can't uncover the reason for its rejection. I was looking forward with great interest to its release and am very disappointed we will never see it.

The same thing happened with flesinoxan a couple years ago- very promising studies but never a release. That was even more disappoinging since it had a reputation for being pro-sexual.

John

 

Re: Gepirone

Posted by SLS on November 4, 2004, at 6:24:45

In reply to Gepirone, posted by Iansf on November 3, 2004, at 23:21:44

> Does anyone know why Gepirone was not approved by the FDA? I came across multiple studies demonstrating its effectiveness, but I can't uncover the reason for its rejection.

Actually, I think it was rejected for a lack of efficacy.

I was looking forward with great interest to its release and am very disappointed we will never see it.

I would have been hesitant to try gepirone because I react badly to Remeron. The metabolite of gepirone, 1-PP, is a potent antagonist of NE alpha-2 receptors, as is Remeron. You would think that this would promote an antidepressant effect for most people. However, it should be noted that Remeron also acts as an antagonist at serotonin receptors (5-HT2a and 5-HT3). This might differeniate the two and explain why gepirone is not as effective.

> The same thing happened with flesinoxan a couple years ago- very promising studies but never a release.

I know. I was even more disappointed by this outcome because flesinoxan is not metabolized into 1-PP.

Thanks for the info.


- Scott

 

Re: Gepirone

Posted by linkadge on November 4, 2004, at 7:27:25

In reply to Re: Gepirone, posted by SLS on November 4, 2004, at 6:24:45

I was dissapointed too, as what we really do need are potent 5-ht1a agonists to help get the most of antianxiety, and antidepressant treatments.

Note: Blocking the 5-h1a receptor blocks virtually all the antidepressant responce in SSRI's


Linkadge


 

buspirone

Posted by zeugma on November 7, 2004, at 13:16:18

In reply to Re: Gepirone, posted by linkadge on November 4, 2004, at 7:27:25

You can always try buspirone (unless that is yet another med your doctor NEVER prescribes). Buspirone is closely related to gepirone, although it is also a weak antagonist at the D2 receptor- this would probably help someone with DA autoreceptor hyperfunction, which may not be an issue for you, but could be for several others on this board.

-z

 

Re: buspirone

Posted by Iansf on November 7, 2004, at 13:38:37

In reply to buspirone, posted by zeugma on November 7, 2004, at 13:16:18

> You can always try buspirone (unless that is yet another med your doctor NEVER prescribes). Buspirone is closely related to gepirone, although it is also a weak antagonist at the D2 receptor- this would probably help someone with DA autoreceptor hyperfunction, which may not be an issue for you, but could be for several others on this board.
>
> -z

Heaven knows if he'll prescribe it. Too many psychiatrists I've visited over the years have been astonishingly rigid, not to mention underinformed, or both. Given that I live in San Francisco, generally one of the most progressive cities in the U.S. and a center of intellectual experimentation, I expected to find a very open-minded psychiatric community. Unfortunately my experience has been the reverse. I have come across some wonderful exceptions, but overall psychiatrists have been some of the coldest, most doctrinaire people I've ever encountered and extraordinarily lacking in compassion. If I didn't constantly get bumped from insurance plan to insurance plan, I could stick with someone I like, but I've suffered through six changes of plans in 10 years. Very discouraging.


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