Psycho-Babble Medication Thread 407541

Shown: posts 1 to 3 of 3. This is the beginning of the thread.

Is Trazodone an SSRI?

Posted by redscarlet on October 26, 2004, at 15:50:24

if not what knid of antidepressant is it?
Thanks

Re: Is Trazodone an SSRI?

Posted by SLS on October 26, 2004, at 16:07:50

In reply to Is Trazodone an SSRI?, posted by redscarlet on October 26, 2004, at 15:50:24

Trazodone (Desyrel) is a phenylpiperazine. It is a weak inhibitor of serotonin (5-HT) reuptake, but it does other things too. It is not really selective. It is also an antagonist of 5-HT2a and NE alpha-1 receptors. Its metabolite, mCPP, is an agonist of 5-HT2b and 5-HT2c receptors. Some literatures states that trazodone is devoid of anticholinergic side effects, others describe mild effects.

- Scott

Re: Is Trazodone an SSRI? » SLS

Posted by King Vultan on October 26, 2004, at 23:27:44

In reply to Re: Is Trazodone an SSRI?, posted by SLS on October 26, 2004, at 16:07:50

> Trazodone (Desyrel) is a phenylpiperazine. It is a weak inhibitor of serotonin (5-HT) reuptake, but it does other things too. It is not really selective. It is also an antagonist of 5-HT2a and NE alpha-1 receptors. Its metabolite, mCPP, is an agonist of 5-HT2b and 5-HT2c receptors. Some literatures states that trazodone is devoid of anticholinergic side effects, others describe mild effects.
>
>
> - Scott
>
>

I just happened to try this stuff again a couple nights ago as a sleep aid for my Parnate insomnia. It was quite a disaster, as 50 mg was seemingly worse than taking nothing, and I barely slept at all. I don't think it blockades ACh receptors really at all, but it gave me nasty dry mouth during the night and constipation the next day. One other thing it does fairly strongly is blockade alpha-2 adrenergic receptors--this has the effect of stimulating NE release and IMO is the only reasonable explanation for these anticholinergic type effects I noticed. This particular blockade and its effects might raise some concern about taking it with an MAOI, but there seems to be plenty of evidence that people have been doing this successfully and safely for years.

Todd

This is the end of the thread.

Show another thread

Psycho-Babble Medication | Extras | FAQ

Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.