Psycho-Babble Medication Thread 390040

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How is Paxil different from other SSRIs?

Posted by 4WD on September 12, 2004, at 16:57:39

Can anyone tell me what about Paxil makes it different from other SSRIs? On most SSRIs I develop a side effect of intense muscle tightness and pain in my neck and shoulders. It makes it impossible for me to take Prozac, Zoloft, Celexa or Lexapro. Paxil, OTOH, doesn't do this. Neither does Effexor or Cymbalta. Why is this?

Marsha

Re: How is Paxil different from other SSRIs?

Posted by King Vultan on September 12, 2004, at 19:00:20

In reply to How is Paxil different from other SSRIs?, posted by 4WD on September 12, 2004, at 16:57:39

> Can anyone tell me what about Paxil makes it different from other SSRIs? On most SSRIs I develop a side effect of intense muscle tightness and pain in my neck and shoulders. It makes it impossible for me to take Prozac, Zoloft, Celexa or Lexapro. Paxil, OTOH, doesn't do this. Neither does Effexor or Cymbalta. Why is this?
>
> Marsha
>

It could have something to do with norepinephrine transmission. Paxil is highly selective for blocking serotonin reuptake, but in absolute terms, it does have the highest affinity for the norepinephrine reuptake transporter of any of the SSRIs. Effexor and Cymbalta are dual serotonin/norepinephrine reuptake inhibitors, so perhaps it is the norepinephrine element that is responsible for the effects you are seeing. If this is actually true, tricyclics and MAOIs should also leave you free from this muscle tightness and pain that you have observed on the SSRIs you indicated.

Todd

Thanks - exactly what I needed to know (nm) » King Vultan

Posted by 4WD on September 12, 2004, at 19:11:34

In reply to Re: How is Paxil different from other SSRIs?, posted by King Vultan on September 12, 2004, at 19:00:20

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