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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by zuzu80 on August 26, 2004, at 18:00:18
Please let me know if it worked or otherwise for you?...
Christine
Posted by zeugma on August 26, 2004, at 19:44:11
In reply to Buspar for Social Anxiety ? Any success stories ?!, posted by zuzu80 on August 26, 2004, at 18:00:18
no, unfortunately it did not... however it does have an antidepressant effect, if it had been marketed as an AD and given an extended-release formulation it might have made a good one.
Posted by Glydin on August 26, 2004, at 20:52:20
In reply to Re: Buspar for Social Anxiety ? Any success stories ?!, posted by zeugma on August 26, 2004, at 19:44:11
Sorry to report a "no" here, too.
Posted by SLS on August 27, 2004, at 12:57:11
In reply to Re: Buspar for Social Anxiety ? Any success stories ?!, posted by zeugma on August 26, 2004, at 19:44:11
> no, unfortunately it did not... however it does have an antidepressant effect, if it had been marketed as an AD and given an extended-release formulation it might have made a good one.
Do you think I should put it on my list of things to try as an augmentor. Which antidepressants do you think it works best with?I am dismayed that the FDA dismissed gepirone. I think it would have made an ideal augmentor.
- Scott
Posted by alesta on August 27, 2004, at 14:24:04
In reply to Re: Buspar for Social Anxiety ? Any success stories ?! » zeugma, posted by SLS on August 27, 2004, at 12:57:11
hi, zuzu! :) zuzu, my research confirms what the others are saying, i'm sorry to report. i haven't heard great things about it for social anxiety, either.
> Do you think I should put it on my list of things to try as an augmentor. Which antidepressants do you think it works best with?scott, my 2 cents: with the cymbalta i agree that if there's anything you're going to need to supplement with, it would be a dopaminergic drug. (but it's hard to say right now if you will need more dopamine b/c cymbalta is supposed to increase dopamine a little bit. so you'll have to wait and see. at least it doesn't *decrease* it as with SSRIs.) i have researched dopaminergic add-ons myself and came up with extended-release ritalin as your best bet in my opinion, if you need to augment.
if the 60 mgs doesn't work for you, i would possibly add that (the ritalin). but i wouldn't go over 60 mg before adding ritalin because adding ritalin will increase blood levels of some neurotransmitters. (besides, i don't think cymbalta has been proven yet to have any greater efficacy over 60 mg a day, but don't quote me on this.)
but i am interested to see how you do without augmentation first for a little while after it kicks in, so you can better see what neurotransmitters you need to target. (we're going to get you well, darn it!) but if you don't want my advice, you can tell me where to go. :) just kidding, but seriously, i don't want to give unwanted advice....:) but i have taken an interest in your case...hope you're doing okay.
take care :),
amy
Posted by alesta on August 27, 2004, at 15:32:20
In reply to Re: Buspar for Social Anxiety ? zuzu sls, posted by alesta on August 27, 2004, at 14:24:04
scott,
one more thing...If you choose to augment, before trying the low-dose Ritalin, you might want to try l-theanine. I’ll give you more details later if you decide to try it. It targets dopamine and gaba. and if by some chance the cymbalta doesn’t work at all, you may want to try l-theanine by itself. (I don’t think you’re going to find many more dopaminergics than those I just listed that either work well or last. See my recent post “dopaminergic add-on to ssri.” just trying to hopefully save you a little legwork, as I just went through this line of questioning concerning dopaminergic add-ons myself. :) but then, of course, I could have missed something. The one other option I’m not sure about is abilify. ok...that's really it!amy :)
Posted by SLS on August 27, 2004, at 15:50:03
In reply to Re: Buspar for Social Anxiety ? -- sls, posted by alesta on August 27, 2004, at 15:32:20
Posted by zeugma on August 27, 2004, at 18:56:20
In reply to Re: Buspar for Social Anxiety ? Any success stories ?! » zeugma, posted by SLS on August 27, 2004, at 12:57:11
> > no, unfortunately it did not... however it does have an antidepressant effect, if it had been marketed as an AD and given an extended-release formulation it might have made a good one.
>
>
> Do you think I should put it on my list of things to try as an augmentor. Which antidepressants do you think it works best with?
>
> I am dismayed that the FDA dismissed gepirone. I think it would have made an ideal augmentor.
>
>
> - ScottHi Scott. I think buspirone is a reasonable choice as a potential add-on, because it hits a lot of neurotransmitters, and has a very short half-life, so if you have an adverse reaction, it's out of there in a hurry. More substantively, I would guess that it works best with NRI's because of its alpha-2 antagonist metabolite. But the drug is highly variable in pharmacokinetics, so although you're guaranteed to get something (5HT 1A partial agonism, NE autoreceptor antagonism, a little bit of D2 blockade) there's no guarantee that you're going to get what you need (or that you're not going to get something you don't need). The name Variza seemed appropriate for the similar gepirone, except of course gepirone came in an ER formulation that would have resulted in a much higher gepirone/1-PP ratio and would not have affected dopamine directly at all. It would have been a lot more predictable, and effective for more people. I agree that it would have made an ideal augmentor.
-z
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