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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by linkadge on June 26, 2004, at 15:23:12
What do the D2 receptors even do ??
Linkadge
Posted by 1980Monroe on June 27, 2004, at 20:47:47
In reply to What on earth are the D2 receptors for ??, posted by linkadge on June 26, 2004, at 15:23:12
Im not sure, but i know its a Dopamine receptor that alot of the stimuants such as amphetamine effect, in the release of dopamine, but thats about all i know.
Posted by gardenergirl on June 28, 2004, at 15:13:11
In reply to What on earth are the D2 receptors for ??, posted by linkadge on June 26, 2004, at 15:23:12
It's hard to easily find stuff on the normal function of these receptors. Everything I found via google and searching my neuropsych. text book talks about D2 receptors in terms of schizophrenia or parkinson's. I did find one article that had more of a summary.
http://www.australianprescriber.com/index.php?content=/magazines/vol17no1/dopamine1.htm
Regards,
gg
Posted by btnd on June 29, 2004, at 1:48:43
In reply to What on earth are the D2 receptors for ??, posted by linkadge on June 26, 2004, at 15:23:12
Low dopamine D(2) receptor binding potential in social phobia
by
Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M.
Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA.
Am J Psychiatry 2000 Mar;157(3):457-9ABSTRACT
OBJECTIVE: This study compared dopamine D(2) receptor binding potential in patients with social phobia and healthy comparison subjects.
METHOD: Dopamine D(2) receptor binding potential was assessed in 10 unmedicated subjects with generalized social phobia and no significant lifetime psychiatric comorbidity and 10 healthy comparison subjects matched for age and sex. Binding potential was measured in the striatum by using single photon emission computerized tomography and constant infusion of the D(2) receptor radiotracer [(123)I]iodobenzamide ([(123)I]IBZM).
RESULTS: Mean D(2) receptor binding potential was significantly lower in the subjects with social phobia than in the comparison subjects. Within the social phobia group, there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score.
CONCLUSIONS: Generalized social phobia may be associated with low binding of [(123)I]IBZM to D(2) receptors in the striatum.
Posted by linkadge on June 29, 2004, at 18:35:12
In reply to Low D2 receptor binding potential in social phobia » linkadge, posted by btnd on June 29, 2004, at 1:48:43
Antipsychotics would worsen social phobia, or improve it.
Linkadge
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