![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by rod on June 22, 2004, at 5:58:47
Does anybody know if Maprotiline gets metabolised into oxaprotiline, or are they 2 different drugs.
I didnt find an answer to this on the internet. So any info is much appreciated.thanks
Roland
Posted by SLS on June 22, 2004, at 7:01:22
In reply to Maprotiline / Oxaprotiline, metabol. or diff. drug, posted by rod on June 22, 2004, at 5:58:47
> Does anybody know if Maprotiline gets metabolised into oxaprotiline, or are they 2 different drugs.
> I didnt find an answer to this on the internet. So any info is much appreciated.
>
> thanks
> Roland
Hi Roland.I infer from these two Medline abstracts that the two drugs are both parent drugs of similar parallel metabolites. They don't seem to be metabolites of each other. I think Chemist would be able to interpret the literature more definitevely.
What's up?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3984384http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6464500
- Scott
Posted by rod on June 22, 2004, at 7:26:50
In reply to Re: Maprotiline / Oxaprotiline, metabol. or diff. drug » rod, posted by SLS on June 22, 2004, at 7:01:22
> > Does anybody know if Maprotiline gets metabolised into oxaprotiline, or are they 2 different drugs.
> > I didnt find an answer to this on the internet. So any info is much appreciated.
> >
> > thanks
> > Roland
>
>
> Hi Roland.
>
> I infer from these two Medline abstracts that the two drugs are both parent drugs of similar parallel metabolites. They don't seem to be metabolites of each other. I think Chemist would be able to interpret the literature more definitevely.
>
> What's up?
>
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3984384
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6464500
>
>
> - ScottDear Scott,
Thanks for taking the time to look this up.
you are right, they seem to be different drugs. :(
I read some interesting things about oxaprotiline. It has an indirect effect on dopamine recepters and so on...
So I will have to deal with Maprotiline.Whats up with me?
Well, not doing so bad.And how are you?
Roland
Posted by SLS on June 22, 2004, at 20:44:09
In reply to Re: Maprotiline / Oxaprotiline, metabol. or diff. drug » SLS, posted by rod on June 22, 2004, at 7:26:50
> Whats up with me?
> Well, not doing so bad.
>
> And how are you?
Not too good, but I've been worse. I'm trying to be patient. I would like to try duloxetine (Cymbalta) next, but I'm not sure when it will become available. Last I heard, it was expected to be approved by the FDA sometime this summer. However, my doctor might be able to get it for me as an investigational drug on an open label basis. I don't know what to hope for anymore. I really should not expect a monoamine reuptake inhibitor to work, as none of them really have in the past. I'm looking at riluzole (Rilutek), a glutamate release inhibitor, as something to try if duloxetine doesn't work out.I've never tried maprotiline. Please keep me informed how you do with it. Thanks. :-)
- Scott
Posted by rod on June 25, 2004, at 5:22:36
In reply to Re: Maprotiline / Oxaprotiline, metabol. or diff. drug, posted by SLS on June 22, 2004, at 20:44:09
> I've never tried maprotiline. Please keep me informed how you do with it. Thanks. :-)
Well, 2 days on it I only can say its very sedative and hard to get out of bed in them morning, which is bad for me :( But, well, It might be too early to say something.
And dont forget that the cortisol antagonist stuff will come out the next few years, hopefully. That sounds very promising.
If Maprotiline isnt the right thing for me, I will quit it and also Abilify, which is activating, but also makes me a bit dysphoric, and switch to Mirapex. I already got a script for this. And I will also try a bit DHEA... Maybe thats doing something positive.
take care
Roland
Posted by rod on July 2, 2004, at 6:01:01
In reply to Re: Maprotiline / Oxaprotiline, metabol. or diff., posted by rod on June 25, 2004, at 5:22:36
Dear Scott,
I dont think you miss something with this drug, Maprotiline. Thats the most sedating drug I have ever taken. And its claimed to have more side effects than Amitriptyline has. Its making me even more lethatgic and apathic during the day and gives me some kind of restless feeling in the night. I was on the minimum dose... I will have to try something lese.
Roland
Posted by KaraS on July 2, 2004, at 12:55:46
In reply to Re: Maprotiline / Oxaprotiline, metabol. or diff., posted by rod on July 2, 2004, at 6:01:01
I'm really surprised at your response to Maprotiline. I've taken that as well as Amitriptyline and Doxepin. Maprotiline was just very mildly sedating for me. I used to take 25 mg. nightly to aid sleep. Doxepin and Amitriptyline were extremely sedating for me. With Amitryptiline, my apartment could have caught on fire and I'd have been too groggy to get up and out the door.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.