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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by aazospiro on March 28, 2004, at 13:00:39
I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
Posted by francesco on March 28, 2004, at 13:52:09
In reply to IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by aazospiro on March 28, 2004, at 13:00:39
> I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
I have no info about it but my experience. I found even 10mg of Imipramine very energizing but experience also agitation while on it. I had to quit for this reason even if I like it. According to the charts it has also SE-reuptake properties.
Francesco
Posted by zeugma on March 28, 2004, at 14:00:07
In reply to Re: IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by francesco on March 28, 2004, at 13:52:09
http://jpet.aspetjournals.org/cgi/content/full/283/3/1305#T3
IMO, the probable reason you had the different reaction to the two meds is because amitriptyline is much more sedating than imipramine. Imipramine, although considered a 'dirty' drug, has high affinities to fewer binding sites than amitriptyline.
Posted by jodeye on March 28, 2004, at 14:55:00
In reply to IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by aazospiro on March 28, 2004, at 13:00:39
> I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
Hello Aazospiro,
You can download a file which may help. It is located at the bottom of my homepage at:
http://www20.brinkster.com/stapro/Let me know if it helps.
--Jay
Posted by King Vultan on March 28, 2004, at 16:21:51
In reply to IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by aazospiro on March 28, 2004, at 13:00:39
> I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
NE reuptake blockade occurs at low dosages without even considering the activity of the desipramine metabolite. Imipramine is the essence of a "dirty" drug and binds to multiple sites of action nearly simultaneously:http://www.preskorn.com/columns/0003.html
Todd
Posted by Sad Panda on March 28, 2004, at 22:46:17
In reply to IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR??, posted by aazospiro on March 28, 2004, at 13:00:39
> I read somewhere that a considerable amount of imipramine is metabolized to desipramine on first pass. Can NE reuptake occur at low doses? Example 12.5 mg? The reason I asked is that it seems to calm me down quite abit without ANY drowsiness. But its a stimulated calmness. I was VERY surprised because amitriptyline made me very very drowsy and heavy. ANYONE KNOW OF ANY SITES WITH DIFINATIVEINFORMATION ON THE FUNDAMENTAL DIFFERENCES ON THESE TRICYCLIC AGENTS?
>
>Here is a table I made with data from http://www.psychotropical.com/
_______________5-HT__NE____H1___5-HT2A__A1___M1
CLOMIPRAMINE__0.28__38____15____23_____50___25
IMIPRAMINE_____1.4___37____37____150____32___60
AMITRIPTYLINE__4.3___35____1_____18_____24___13
DOTHIEPIN______8.6___46____3.6__________450__38
NORTRIPTYLINE_18____4.3___6.3___41_____55___50
DESIPRAMINE_________0.83__60____350____100__210
DOXEPIN________68____29.5__0.2___27_____23___52
MIANSERIN______4000________0.4__________34_____
MIRTAZAPINE________________0.12__30____________
NEFAZODONE____200_________24000_26_____48_____
VENLAFAXINE____8.9___1060__35000________35000__
PAROXETINE_____0.13__40______________________80
SERTRALINE_____0.29________24000________380__1300
FLUOXETINE_____0.81__240_________280_________1000
CITALOPRAM_____1.16____________________________
FLUVOXAMINE____2.2_____________________________Imipramine is a very weak H1 blocker, Ami is strong. Sorry the table is hard to read, this board doesn't allow for tabs or spaces.
Cheers,
Panda.
Posted by aazospiro on March 29, 2004, at 9:43:14
In reply to Re: IMIPRAMINE? AT WHAT DOSE DOES NE REUPTAKE OCCUR?? » aazospiro, posted by Sad Panda on March 28, 2004, at 22:46:17
Thanks again to Panda and Fransesco. I live in St. Vincent Fransesco. Imipramine has only been taken for about 6 days. It makes me a bit jittery in the morning for which pindolol 5 mg helps alot with. Concentration is alot better. However when I did the Dr. Amen's test online, I was said to have been ADHD mixed with anxiety and mild depression. It seems to me that I am one of those people who may benefit from very low-dose combinations.
However dopaminergic agents here is only the d-agonists like the dirty bromocriptine and reuptake inhibitor bupropion which is $$$$$$$ like I said many times before.
So my idea is to add 18.75 mg venlafaxine twice a day with 100/10 Sinemet also twice a day, if after another week, no significant improvement in low mood.
What do you think? I have read reports where l-dopa seems to do very well with some ADHD patients as a low dose adjunct.............
This is the end of the thread.
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