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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Jaynee on February 28, 2004, at 17:26:33
Sumitomo Pharmaceuticals Co. Ltd. Releases Serotonin-Agonist Antianxiety Drug In China
Sumitomo Pharmaceuticals announced on February 24 that it started to distribute "Sediel," a serotonin-agonist antianxiety drug, in China in February.
Posted by Jaynee on February 28, 2004, at 17:39:53
In reply to Opinions on this drug please - Sediel?, posted by Jaynee on February 28, 2004, at 17:26:33
Here is more info on this drug. I know I am not supposed to ask, but desperation is desperation, how can I get this drug?
J Pharmacol Exp Ther. 1994 Nov;271(2):683-94. Related Articles, Links
Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans.Evans SM, Troisi JR 2nd, Griffiths RR.
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Tandospirone is a novel nonbenzodiazepine anxiolytic/antidepressant that acts primarily at the serotonin-1A receptor. In the present study, the behavioral effects and abuse liability of tandospirone were characterized relative to those of the benzodiazepine, alprazolam. In an outpatient setting, the acute effects of placebo, tandospirone citrate (40, 80 and 160 mg) and alprazolam (0.5, 1.0 and 2.0 mg) were assessed with a double-blind, cross-over design in 14 male volunteers with histories of sedative drug abuse. Drug effects were assessed on behavioral performance tasks; observer ratings of drug effect; and subject ratings of strength of drug effect, mood and drug liking. Both alprazolam and tandospirone produced comparable dose-related increases in subject- and observer-rated strength of drug effect. The peak drug effect occurred approximately 2 hr after drug administration; the time to peak did not differ between the two drugs. Alprazolam produced greater impairments on psychomotor performance than did tandospirone. Alprazolam produced dose-related increases in subject-rated drug liking; tandospirone, in contrast, produced dose-related increases in subject-rated drug disliking. The highest dose of alprazolam was predominantly classified by subjects as being a benzodiazepine or a barbiturate (71%) in contrast to the highest dose of tandospirone (29%). Across subjects, tandospirone plasma concentrations after a single dose of 160 mg were significantly correlated with several subjective and behavioral measures. The present study demonstrates that tandospirone and alprazolam can be clearly differentiated on the basis of subjective effects and performance measures. The overall profile indicates that tandospirone has a significantly lower abuse liability than does alprazolam.
Posted by Ilene on February 28, 2004, at 18:15:47
In reply to Okay, I want this drug ..........................., posted by Jaynee on February 28, 2004, at 17:39:53
> Here is more info on this drug. I know I am not supposed to ask, but desperation is desperation, how can I get this drug?
>
> J Pharmacol Exp Ther. 1994 Nov;271(2):683-94. Related Articles, Links
>
>
> Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans.
>
> Evans SM, Troisi JR 2nd, Griffiths RR.
>
> Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
>
> Tandospirone is a novel nonbenzodiazepine anxiolytic/antidepressant that acts primarily at the serotonin-1A receptor. In the present study, the behavioral effects and abuse liability of tandospirone were characterized relative to those of the benzodiazepine, alprazolam. In an outpatient setting, the acute effects of placebo, tandospirone citrate (40, 80 and 160 mg) and alprazolam (0.5, 1.0 and 2.0 mg) were assessed with a double-blind, cross-over design in 14 male volunteers with histories of sedative drug abuse. Drug effects were assessed on behavioral performance tasks; observer ratings of drug effect; and subject ratings of strength of drug effect, mood and drug liking. Both alprazolam and tandospirone produced comparable dose-related increases in subject- and observer-rated strength of drug effect. The peak drug effect occurred approximately 2 hr after drug administration; the time to peak did not differ between the two drugs. Alprazolam produced greater impairments on psychomotor performance than did tandospirone. Alprazolam produced dose-related increases in subject-rated drug liking; tandospirone, in contrast, produced dose-related increases in subject-rated drug disliking. The highest dose of alprazolam was predominantly classified by subjects as being a benzodiazepine or a barbiturate (71%) in contrast to the highest dose of tandospirone (29%). Across subjects, tandospirone plasma concentrations after a single dose of 160 mg were significantly correlated with several subjective and behavioral measures. The present study demonstrates that tandospirone and alprazolam can be clearly differentiated on the basis of subjective effects and performance measures. The overall profile indicates that tandospirone has a significantly lower abuse liability than does alprazolam.
>
>
I don't think this drug is marketed here. It's manufactured by a Japanese company. You can probably get it in Japan or perhaps by enrolling in a clinical trial, if there are any.I.
Posted by zeugma on February 28, 2004, at 18:45:52
In reply to Okay, I want this drug ..........................., posted by Jaynee on February 28, 2004, at 17:39:53
Posted by TheOutsider on February 29, 2004, at 12:05:39
In reply to this drug looks like buspirone (nm), posted by zeugma on February 28, 2004, at 18:45:52
It does seem to have some similarities, but I would not assume that it would be as useless as Buspirone!
You probably weren't doing this, but just to warn anyone who might think that.I don't think Buspirone proves that seretonin agonists don't work, in the same way that Moclobemide doesn't prove that all MAOI's are not very good.
What I'm trying to say is don't assume that one bad drug makes a whole class of drugs bad.Appologies for spelling-am dyslexic
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