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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by bipolarspectrum on January 3, 2004, at 1:23:43
Hello all,
I just recently underwent ECT to no avail... although the treatment wasnt as bad in terms of side-effects, there was no significant improvement in my depression.. I'm going to see the old pdoc on Monday and I was wondering if anyone had any experience with this prozac and naltroxene-opiod antagonist combo... I know, its pretty absurb, but thats all I've got left..
Thanks for your attention..
Posted by brussell on January 3, 2004, at 3:37:48
In reply to Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by bipolarspectrum on January 3, 2004, at 1:23:43
I'm really sorry ECT didn't work for you.
I don't know anything about the combo that you're trying, but I'm glad you are trying something new.
This may be a dumb question, but I'm assuming you tried Nardil and Parnate at maximum dosages with no result?
Posted by SLS on January 3, 2004, at 7:58:51
In reply to Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by bipolarspectrum on January 3, 2004, at 1:23:43
> I'm going to see the old pdoc on Monday and I was wondering if anyone had any experience with this prozac and naltroxene-opiod antagonist combo... I know, its pretty absurb, but thats all I've got left..
Hi.
I just wanted to let you know that that combination is not without precedent. Naltrexone augmentation was a hot topic on Psycho-Babble a few years back. I can't comment on its effectiveness, but at least one person reported dramatic results in the treatment of depression.
- Scott
Posted by Asian Girl on January 3, 2004, at 8:21:42
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by SLS on January 3, 2004, at 7:58:51
Hello B.S.
I'm very sorry that ECT didn't work for you. I'm not knowlegable about meds. I just want to give you some emotional support. Hang in there, don't give up, you will find the right med combo eventually.
I am in a self medication state. I lowered my Topmax from 50 mg to 25 mg and added 12.5 paxil cr to my existing 1.5mg klonopin. My depression is improved a lot. ( My Pdoc wanted to stop treating me with meds and put me on ECT. I decided not do now before trying more med combos)
My new psy doc. appointment is in Feb.
I also thank you for your past support.
Asian Girl
Posted by bipolarspectrum on January 3, 2004, at 11:24:11
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by brussell on January 3, 2004, at 3:37:48
To whom it may concern,
My gratitude for the continued support, it always surprises me how much 'electronic' support can mean to an individual... concerning my meds, i tried nardil, but it was supplemented with risperidal, the atypical antipsychotic... i believe i 'may' have experienced hypomania on nardil, thats why the risperdal was added, in hopes of controlling hypomania... I'm wondering whether its useful to ask the pdoc if I may return to nardil monotherapy, this time at a lower dose, such that I will tip the balance...
Also, these new atypical antipsychotics, geodon and abilify, does anyone experience a significant antidepressant quality to them??"Although it may make you feel like you want to die, it will never kill you"
A cliche I know, but an appropriate one nevertheless..
Posted by Jaynee on January 3, 2004, at 12:56:30
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by bipolarspectrum on January 3, 2004, at 11:24:11
bipolarspectrum - I am sorry to hear the ECT didn't work. I may be out in left field, but I posted an article about an MRI that is helping bipolar patients. Maybe you could look this up and see if there are any clinical trials being done yet. I will look up Prozac and Naltroxene and see what links I come up with.
Here is the article on the MRI
http://www.sciencedaily.com/releases/2004/01/040101091614.htm
Good luck.
Posted by brussell on January 3, 2004, at 13:05:12
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by Jaynee on January 3, 2004, at 12:56:30
Hi,
I'm glad to hear your new combination has worked for some people. I just wanted to add that while Nardil and Parnate are both MAOIs, they are very different chemically and can have very different effects on the same person. There's a chance Parnate won't make you hypomanic even if Nardil does.
Posted by Jaynee on January 3, 2004, at 13:12:28
In reply to Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by bipolarspectrum on January 3, 2004, at 1:23:43
Here is some interesting info for you:
Am J Psychiatry. 2004 Jan 1;161(1):171-174. Related Articles, Links
An Open-Label Trial of Riluzole in Patients With Treatment-Resistant Major Depression.Zarate CA Jr, Payne JL, Quiroz J, Sporn J, Denicoff KK, Luckenbaugh D, Charney DS, Manji HK.
OBJECTIVE: This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in patients with recurrent major depression. METHOD: After a 1-week drug-free period, subjects 18 years or older with a diagnosis of recurrent major depression and a Montgomery-Asberg Depression Rating Scale score >/==" BORDER="0">20 received riluzole monotherapy (100-200 mg/day) openly for 6 weeks. RESULTS: Nineteen treatment-resistant depressed patients, 53% of whom were classified as having stage 2 treatment resistance or greater, received riluzole at a mean dose of 169 mg/day. Significant improvement occurred during weeks 3 through 6 for all patients and weeks 2 through 6 for completers. CONCLUSIONS: Although preliminary, these results indicate that riluzole may have antidepressant properties in some patients.
PMID: 14702270 [PubMed - as supplied by publisher]
Posted by bipolarspectrum on January 3, 2004, at 14:38:23
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by Jaynee on January 3, 2004, at 13:12:28
Thanks for the input everyone,
The glutamate antagonist and MRI seem very promising, but my pdoc is a fan of the evidence-based treatments... my problem is not so much treatment resistance, but rather a sensitivity to all medications.. I cannot seem to tolerate any antidepressants, mood stabilizers or anti-psychotics... prozac is the only one that i mildly tolerated, but it left me with broken, unrefreshing sleep and much anxiety...
im hoping for some similar stories with sunny endings??
Posted by wsj on January 3, 2004, at 19:14:26
In reply to Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by bipolarspectrum on January 3, 2004, at 1:23:43
what type ect did you under go? how many sessions?
best to ya!
wsj
Posted by bipolarspectrum on January 3, 2004, at 19:52:26
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene » bipolarspectrum, posted by wsj on January 3, 2004, at 19:14:26
Hey wsj,
I underwent 5 unilateral and 6 bilateral without significant improvement...> what type ect did you under go? how many sessions?
>
> best to ya!
>
> wsj
Posted by wsj on January 4, 2004, at 0:18:11
In reply to Re: Failed ECT- Prozac (fluoxetine) and Naltroxene, posted by bipolarspectrum on January 3, 2004, at 19:52:26
you say w/o significant improvement. i read b/t the lines that you had some improvement.
i am assuming your pdoc is the one that declared the ect a failure? i am curious what the failure was based on?best to ya!
wsj
Posted by bipolarspectrum on January 4, 2004, at 16:30:33
In reply to Re: Failed ECT- Prozac .... » bipolarspectrum, posted by wsj on January 4, 2004, at 0:18:11
Hey wsj,
Well I didnt experience this great improvement in mood that ect supposedly provides.. it may have improved my psychomotor functioning, but other than that, i am still very depressed... but my fate is coming down to whether the treatments can somehow make me more tolerant of medication, i can only hope
sincerely,
bipolarspectrum
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