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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by falconman on December 9, 2003, at 8:24:17
Hi mate,
How has Nardil/Amisulpride mix effected you? Can you briefly explain the 'prolactin problem'with zyprexa/amisulpride?My Pdoc said when I reach the highest tolerable dose of Nardil he'd add zyprexa. I'm on 60mg of Nardil/day. I've been on it for 6 weeks and the side effects are pretty bad- Very low blood pressure,cognitive dysfunction(worst,I can't remember words for things etc.),Shakey limbs,can't exersize,disorientated,water retention,constipation,not to mention my little man doesn't work but I fully expected that one. When I begun it was much worse than now, butI seem to have stabalized at this point(which isn't great). This is very annoying cause it is helping the depression,social phobia,depersonalization a little bit. I wish I could get more down me, but this is the most I will get out of nardil.
I'm seeing my Pdoc tommorrow and its time to augment. I'm a bit weary of zyprexa, I don't want any more side effects + won't it actually reduce dopamine/seratonin levels? I know I need a dopamine hit so I'm going to push for the amisulpride instead.
I wish I could get more nardil in me man
peace Mark
Posted by ace on December 9, 2003, at 19:30:18
In reply to NARDIL QUESTION - ACE, posted by falconman on December 9, 2003, at 8:24:17
> Hi mate,
>'Mate'? Are you an Aussie too!! It's good to hear, with all the 'yanks' on this site!!!
How has Nardil/Amisulpride mix effected you?
No real effect yet. I feel confident but. I have been on 50mg for only 1 week 3 days. I'll give it a month- I'm sure it will kick in before that though. I let you know when it kicks in!
Can you briefly explain the 'prolactin problem'with zyprexa/amisulpride?Yeah sure. As you probably know both Amisulpride and Zyprexa both on their own raise prolactin levels. So when combine this will be more so. A high serum level concentration of prolactin can lead to potency, headaches, visual problems and more. I really don't think that there is too much chance of this however. Just monitor the two and all should be cool.
> My Pdoc said when I reach the highest tolerable dose of Nardil he'd add zyprexa. I'm on 60mg of Nardil/day.
I believe you should raise to 90mg after 4 weeks on 60mg. Also, I would keep Zyprexa at 2.5mg, no higher- this is my experience though. At higher than 2.5mg it felt like it worked against Nardil and cause me a bad depression.
I've been on it for 6 weeks and the side effects are pretty bad- Very low blood pressure,I've never has this really.
cognitive dysfunction(worst,I can't remember words for things etc.)
Had this BIG TIME for a short while- it passed though.
,Shakey limbs
Had a bit. Passed but.,can't exersize,
I never really exercise anyway!!
disorientated,Had this for a while too- it passed.
water retention,didn;t really have it I think.
constipation,
Yeah, got this right now. It does pass but does take quite some time usually. Eat bran.
not to mention my little man doesn't work but I fully expected that one.Dude, I know about that! Mine has just died recently after 9 weeks or so back on Nardil. I thought I had made it, but my penis just had to go on me!!!!!!!!!!! Can't believe it!!
When I begun it was much worse than now, butI seem to have stabalized at this point(which isn't great). This is very annoying
Please be patient. Nardil s/effects nearly all pass. Just time, sweet time.
cause it is helping the depression,social phobia,depersonalization a little bit. I wish I could get more down me, but this is the most I will get out of nardil.For the moment. Give it a bit more time for the s/effects to pass, then I recommend raising dosage again.
>
> I'm seeing my Pdoc tommorrow and its time to augment. I'm a bit weary of zyprexa, I don't want any more side effects + won't it actually reduce dopamine/seratonin levels?Probably not at 2.5mg that I'm aware off- but, yeah, I wouldn't be too confident at the moment with this. Why not try...
1 Amisulpride? (DA added activity completely)
2. Lithium? (5HT added activity mostly)
2. Pindolol? (5HT added activity mostly)
3. Trazadone? ( reckon this would be great with Nardil) (5HT added activity mostly)
I know I need a dopamine hit so I'm going to push for the amisulpride instead.Good idea!! Remeber there is Mirapex too. Too bad this is not in Australia- I would probably give it a go.
> I wish I could get more nardil in me man
> peace MarkPeace to you brother. I reckon give the Nardil some more time to lett s/eefects pass- believe me most do- just for some they take a while.
good luck!
Ace.
Posted by falconman on December 10, 2003, at 5:10:56
In reply to Re: NARDIL QUESTION - ACE » falconman, posted by ace on December 9, 2003, at 19:30:18
> > Hi mate,
> >
>
> 'Mate'? Are you an Aussie too!! It's good to hear, with all the 'yanks' on this site!!!
>
> How has Nardil/Amisulpride mix effected you?
>
> No real effect yet. I feel confident but. I have been on 50mg for only 1 week 3 days. I'll give it a month- I'm sure it will kick in before that though. I let you know when it kicks in!
>
>
> Can you briefly explain the 'prolactin problem'with zyprexa/amisulpride?
>
> Yeah sure. As you probably know both Amisulpride and Zyprexa both on their own raise prolactin levels. So when combine this will be more so. A high serum level concentration of prolactin can lead to potency, headaches, visual problems and more. I really don't think that there is too much chance of this however. Just monitor the two and all should be cool.
>
> > My Pdoc said when I reach the highest tolerable dose of Nardil he'd add zyprexa. I'm on 60mg of Nardil/day.
>
> I believe you should raise to 90mg after 4 weeks on 60mg. Also, I would keep Zyprexa at 2.5mg, no higher- this is my experience though. At higher than 2.5mg it felt like it worked against Nardil and cause me a bad depression.
>
>
> I've been on it for 6 weeks and the side effects are pretty bad- Very low blood pressure,
>
> I've never has this really.
>
> cognitive dysfunction(worst,I can't remember words for things etc.)
>
> Had this BIG TIME for a short while- it passed though.
>
>
> ,Shakey limbs
>
>
> Had a bit. Passed but.
>
> ,can't exersize,
>
>
> I never really exercise anyway!!
>
>
> disorientated,
>
> Had this for a while too- it passed.
>
>
> water retention,
>
> didn;t really have it I think.
>
> constipation,
>
>
> Yeah, got this right now. It does pass but does take quite some time usually. Eat bran.
>
>
> not to mention my little man doesn't work but I fully expected that one.
>
> Dude, I know about that! Mine has just died recently after 9 weeks or so back on Nardil. I thought I had made it, but my penis just had to go on me!!!!!!!!!!! Can't believe it!!
>
>
>
> When I begun it was much worse than now, butI seem to have stabalized at this point(which isn't great). This is very annoying
>
> Please be patient. Nardil s/effects nearly all pass. Just time, sweet time.
>
>
> cause it is helping the depression,social phobia,depersonalization a little bit. I wish I could get more down me, but this is the most I will get out of nardil.
>
> For the moment. Give it a bit more time for the s/effects to pass, then I recommend raising dosage again.
>
>
> >
> > I'm seeing my Pdoc tommorrow and its time to augment. I'm a bit weary of zyprexa, I don't want any more side effects + won't it actually reduce dopamine/seratonin levels?
>
> Probably not at 2.5mg that I'm aware off- but, yeah, I wouldn't be too confident at the moment with this. Why not try...
> 1 Amisulpride? (DA added activity completely)
> 2. Lithium? (5HT added activity mostly)
> 2. Pindolol? (5HT added activity mostly)
> 3. Trazadone? ( reckon this would be great with Nardil) (5HT added activity mostly)
>
>
> I know I need a dopamine hit so I'm going to push for the amisulpride instead.
>
> Good idea!! Remeber there is Mirapex too. Too bad this is not in Australia- I would probably give it a go.
>
>
> > I wish I could get more nardil in me man
> > peace Mark
>
> Peace to you brother. I reckon give the Nardil some more time to lett s/eefects pass- believe me most do- just for some they take a while.
>
> good luck!
>
> Ace.
Hi,
cheers man. Not an aussie, I'm from the UK. My pdoc reckons that I've been on nardil long enough and by know the side effects that I've got are here to stay. We both agreed that I've probably got the most out of it and I shouldn't raise the dose. He evan talked about dropping to 45mg. I convinced him that I'd like to keep on 60mg for the moment with the slight posability that the side effects would drop in the next 4 weeks or so.He wanted to stick me on 2.5 zyprexa but I spoke to him about the amisulpride, and I'm adding this instead at 100mg/day. I'll see how this effects me. Hopefully one day I can increase the Nardil though.
Cheers for your responce, its good to here from another budding psychiatrist who's in a similar position to me. I hope your amisulpride kicks in soon. I thought it was known to start working really rapidly. Would you not try and increase it to 100mg?
Peace
Posted by maryhelen on December 11, 2003, at 11:35:16
In reply to Re: NARDIL QUESTION - ACE » falconman, posted by ace on December 9, 2003, at 19:30:18
Ace:
You say that if Mirapex was available in Australia you would try it. Would this be in place of Nardil? My understanding is that Mirapex is indicated for Parkinson Disease. What would you try Mirapex for? It sounds like another type of MAOI that I have heard of. I am just trying to sort out what to do, as I am apparently taking the 'new' Nardil but have to try and remain hopeful that I will find a way to get the 'old' Nardil and it will help with my depression. You have been such a proponent of Nardil and your firm belief in it has been the main reason I have tried it and hold on to a glimmer of hope that it will also help me, that if you stopped taking it I would feel so discouraged.
Would you be able to explain what Mirapex is and why you would like to try it? I hope you don't mind me asking.
Thanks
maryhelen
Posted by ace on December 11, 2003, at 18:27:25
In reply to Ace, Mirapex question ...., posted by maryhelen on December 11, 2003, at 11:35:16
> Ace:
>
> You say that if Mirapex was available in Australia you would try it. Would this be in place of Nardil? My understanding is that Mirapex is indicated for Parkinson Disease. What would you try Mirapex for? It sounds like another type of MAOI that I have heard of. I am just trying to sort out what to do, as I am apparently taking the 'new' Nardil but have to try and remain hopeful that I will find a way to get the 'old' Nardil and it will help with my depression. You have been such a proponent of Nardil and your firm belief in it has been the main reason I have tried it and hold on to a glimmer of hope that it will also help me, that if you stopped taking it I would feel so discouraged.
>
> Would you be able to explain what Mirapex is and why you would like to try it? I hope you don't mind me asking.
>
> Thanks
>
> maryhelenOf course you can ask! Don't worry I will always stay on the wonder drug called Nardil. I Love it! Unfortunately, I suffer from very severe and atypical OCD- the Mirapex is a drug which will add more Dopamine in my brain along with Nardil. If my OCD is caused by low dopamine levels, the Mirapex will kill it.
Mirapex is not an MAOI.
Just to be clear, Nardil is a wonder drug, and it has helped me in so many ways. It has been good to me. For instance, it is absolutely Killing my anxiety. I am at my uni library now having fun- without Nardil I would probably be home scared and depressed.
Nardil is great...I LOVE IT-- PERIOD!!!!!
One question: did you get my last post- i could not see your response...you might be able to import the OLD Nardil from Australia. In the mean time, the new Nardil seems to work a lot for some users, but not those unfortunate ones who had to swap from old to new.
Keep in touch and I will always happily answer any questions.
Ace.
Posted by ace on December 11, 2003, at 18:34:50
In reply to Re: NARDIL QUESTION - ACE, posted by falconman on December 10, 2003, at 5:10:56
>
> Hi,
> cheers man. Not an aussie, I'm from the UK. My pdoc reckons that I've been on nardil long enough and by know the side effects that I've got are here to stay.I have to disagree with that. Rarely do some stay always. Mostly they all go...with time...some times lots!
We both agreed that I've probably got the most out of it and I shouldn't raise the dose.I'd beg to differ. I really would. 90mg is the killer dose. For some people NEED this dose due to indivual metabolic reasons.
But it's your decision of course.
He evan talked about dropping to 45mg. I convinced him that I'd like to keep on 60mg for the moment with the slight posability that the side effects would drop in the next 4 weeks or so.
Good idea.
> He wanted to stick me on 2.5 zyprexa but I spoke to him about the amisulpride, and I'm adding this instead at 100mg/day. I'll see how this effects me. Hopefully one day I can increase the Nardil though.
Yeah, I think you WILL be able ti increase it with time. But Amsisulpride is great. Man, you have to let me know how you go- we are on the same combo!!!!
> Cheers for your responce, its good to here from another budding psychiatrist who's in a similar position to me.Really?! You want to be a psychiatrist? Excellent! Technicall, I want to be a psychopharacologist. I am entering med school as a post graduate- i have some physics and chemistry units left then I go in. Also, I have studied a lot of philosophy units- they love that at the moment...they used to have brainiac doctors with no social skills!
I hope your amisulpride kicks in soon. I thought it was known to start working really rapidly.
Thanks dude. I've heard of it taking 4 weeks. I think it's started working now, but will show full effects after a week.
Would you not try and increase it to 100mg?
Possibly...I'll give it 4 weeks on 50mg. I am also on 90mg Nardil, but if I was on lower Nardil dose, yeah, I'd probably go straight for 100mg Ami.
Peace to you, keep in contact!Ace.
> Peace
Posted by maryhelen on December 12, 2003, at 11:08:12
In reply to Re: Ace, Mirapex question .... » maryhelen, posted by ace on December 11, 2003, at 18:27:25
Hi Ace:
I haven't been able to be on the computer often, hard to drag myself out of bed. I cannot find the post you mentioned talking about how to import Nardil from Australia. I am not sure what thread you put it on, but I did post to you on December 11th on .. Ace, please help... outraged. I don't know what other thread to look at. I do get confused lately.
As always, thanks Ace. Hope you are doing well.
maryhelen
This is the end of the thread.
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