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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by linkadge on October 14, 2003, at 8:53:12
I have been taking parnate for 1 week now.
Somtimes you hear things like - "increase dose untill full MAO inhibion is achieved - then lower dose to maintenance dose."
How do they know when "full MAO inhibition" has been achieved?Secondly what generally is a standard maintainace dose of this drug?
Can the same responce be had from a low maintaince dose (just take longer) as a high
dose? I'm just unsure about how MAO responds
to MAOI inhibitors.Linkadge
Posted by djmmm on October 14, 2003, at 11:40:55
In reply to Parnate questions, posted by linkadge on October 14, 2003, at 8:53:12
> I have been taking parnate for 1 week now.
>
> Somtimes you hear things like - "increase dose untill full MAO inhibion is achieved - then lower dose to maintenance dose."
>
>
> How do they know when "full MAO inhibition" has been achieved?
Officially..."When satisfactory response occurs, gradually reduce to maintenance level."
>
> Secondly what generally is a standard maintainace dose of this drug?
10mg in the morning...but I don't hear a lot about maintenance dose and MAOIs...everyone I seem to know, will take the med for months/years at the effective dose (30-40mg) and then gradually stop.
>
> Can the same responce be had from a low maintaince dose (just take longer) as a high
> dose? I'm just unsure about how MAO responds
> to MAOI inhibitors.
>
> Linkadge
Well, in theory, you should get the same response to a maintenance dose as you would the effective dose (after a full response to the effective dose)
When it comes to MAOIs, a maintenance dose is possible only because of the amount of time your cells need to re-synthesize MAO. If you have a full response to 40mg at week 8 (depending on your Dr.) s/he may decrease to a maintenance dose of 10mg, which whould still keep MAO activity down (since, in theory, theraputic response occurs @ 80% MAO inhibtion)
In my opinion, after being on both Nardil and Parnate, a lot of the theraputic effects are immediate...for example, parnate's immediate effects may involve stimulation of catecholamine release, etc.
This is the end of the thread.
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