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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by utopizen on April 8, 2003, at 19:56:45
Hey, doesn't GHB (Xyrem) act as a type of growth hormone? If so, would taking Xyrem help social anxiety disorder?
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A preliminary study of baclofen-induced growth hormone release in generalised social phobia.
Condren RM, Lucey JV, Thakore JH.
Neuroscience Department, St Vincent's Hospital, Richmond Road, Fairview, Dublin 3, Ireland.
OBJECTIVE: The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen. METHOD: Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period. RESULTS: The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response. CONCLUSIONS: The results suggest an abnormality of central GABA(B) receptor function in this disorder. Copyright 2002 John Wiley & Sons, Ltd.
PMID: 12590406 [PubMed - in process]
Posted by Questionmark on April 9, 2003, at 0:58:46
In reply to Growth Hormone? Social Anxiety?, posted by utopizen on April 8, 2003, at 19:56:45
> Hey, doesn't GHB (Xyrem) act as a type of growth hormone? If so, would taking Xyrem help social anxiety disorder?
>
> ----------
> A preliminary study of baclofen-induced growth hormone release in generalised social phobia.
> Condren RM, Lucey JV, Thakore JH.
> Neuroscience Department, St Vincent's Hospital, Richmond Road, Fairview, Dublin 3, Ireland.
> OBJECTIVE: The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen. METHOD: Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period. RESULTS: The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response. CONCLUSIONS: The results suggest an abnormality of central GABA(B) receptor function in this disorder. Copyright 2002 John Wiley & Sons, Ltd.
> PMID: 12590406 [PubMed - in process]Weird. Why would growth hormone help with social anxiety i wonder?
i believe GHB does not act as a growth hormone, it stimulates production and/or release of growth hormone. i thought it does this by means of elevating dopamine levels (as a rebound effect) though. Is GABA(B) stimulation responsible for the rebound DA then (judging from this abstract)? Or am i just mistaken about the involvement of DA? No, i don't think i am though.
Also, if increased DA activity stimulates more GH production/release, then why do psychostimulants suppress growth (and i believe growth HORMONE activity)??? CONFUSION!!
Posted by Carlos C on April 9, 2003, at 20:45:12
In reply to Re: Growth Hormone? Social Anxiety? ( more Q.s), posted by Questionmark on April 9, 2003, at 0:58:46
I've taken GHB for weeks at a time for depression and horrible anxiety. It works like a charm for both. It has a instant set-on (about 10 minutes) but unfortunately it also has a very short half-life of about one hour. The other bad side is how dramatically a small dose increase can cause such side-effects as heavy sedation/REM sleep induction and even vomiting. So, yes it dose work wonders for depression and anxiety (nothing works as good if you ask me) but if you decide to use it start off with a smaller than suggested does and go up very slowly till you reach desired effects. Don't worry about tolerance because there is only one "always-works" dose.
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