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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by ace on February 17, 2003, at 20:12:19
Does Anybody have any literature which has statistics on the risk of Tardive Dyskinesia with Zyprexa and/or Risperidone? Kept at low-mid doses these atypical antipsychotics are ments to be safe for years. I heard of someone on Thorazine (an older neuroleptic) for ten years low dose for panic. She had no probs.
Posted by Thomas123 on February 17, 2003, at 21:12:48
In reply to Risk of TD with Zyprexa or Risperidone - figures?, posted by ace on February 17, 2003, at 20:12:19
Atypicals are not perfectly safe.
Nithsdale Schizophrenia Surveys 23: movement disorders. 20-year review.Halliday J, Farrington S, Macdonald S, MacEwan T, Sharkey V, McCreadie R.
Department of Clinical Research, Crichton Royal Hospital, Dumfries, UK. mikejenq@tinyworld.co.uk
BACKGROUND: In the past 10 years the new atypical antipsychotic drugs have stimulated further interest in the pharmacological management of schizophrenia. The risk of movement disorders has been reported to be less with these new agents. AIMS: To examine the current prevalence of movement disorders among all people with schizophrenia in a discrete geographical area, to compare the prevalence in patients receiving and not receiving atypical antipsychotic drugs; and to compare current prevalence with prevalence over the past 20 years. METHOD: In Nithsdale, south-west Scotland, in 1999/2000, we replicated previous studies by using the Abnormal Involuntary Movements Scale, Simpson-Angus scale and Barnes Akathisia Rating Scale to measure tardive dyskinesia, parkinsonism and akathisia, respectively. Mental state was assessed by the Positive and Negative Syndrome Scale. RESULTS: In 136 patients the prevalence of probable tardive dyskinesia was 43%, of parkinsonism 35% and of akathisia 15%. Parkinsonism was present as often in those receiving atypicals as in those receiving standard oral antipsychotics. The prevalence of tardive dyskinesia has doubled over 20 years. CONCLUSIONS: Movement disorders remain significant problems for patients despite the introduction of atypical antipsychotic drugs.
Posted by Guy on February 18, 2003, at 21:15:52
In reply to Re: Risk of TD with Zyprexa or Risperidone - figures?, posted by Thomas123 on February 17, 2003, at 21:12:48
I'm not sure this study is a good indicator
of TD risks with atypicals. The study would only be valid if those on atypicals had never been on the older AP's. Many of the TD cases may have been switched to atypicals after having used the old meds. Therefore, the results would be inconclusive. Also, TD can manifest itself long after drug cessation. More information is needed to convince me that this study is valid
This is the end of the thread.
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