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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Lawrence S. on January 23, 2003, at 1:27:31
Anyone know if this combo is safe? If I recall, serzone is a close relative to trazadone which can be taken with nardil.
Posted by djmmm on January 23, 2003, at 9:35:31
In reply to serzone and nardil ok??, posted by Lawrence S. on January 23, 2003, at 1:27:31
Most likely not. Serzone is more potent in terms of serotonin re-uptake. Both serzone and trazodone are 5ht-2 agonists, but, again Serzone has a far greater reuptake properties...
trazodone also differs in that it has an active metabolite (m-chloropiperazine) which is a potent dopamine blocker (D2)
Posted by Ame Sans Vie on January 23, 2003, at 13:18:20
In reply to serzone and nardil ok??, posted by Lawrence S. on January 23, 2003, at 1:27:31
As djmmm pointed out, Serzone is quite a bit more potent regarding its AD properties-- trazodone is rarely effective (except in very high doses) and is normally used as a sleep-aid (well... actually a 'knock-yourself-out" aid, if you ask me, lol). Though they are both 5HT2 antagonist reuptake inhibitors (SARIs), I speculate that the use of low-dose trazodone for insomnia carries with it very little risk of serotonin syndrome and NMS, as partially backed-up by the following links:
http://www.serzone.com/safety_info.html
http://www.rxlist.com/cgi/generic/nefaz_ad.htm
The nefazodone FAQ located in the tips section of this site also makes mention of the potential interaction.
I wasn't able to find any info (yet) regarding the specific P450 isozyme(s) involved in metabolism of Nardil... but I would *certainly* not attempt Serzone with Nardil if it so happens that the latter is largely metabolized through isozyme IIIA4,5,7. Serzone is a terribly potent inhibitor of this isozyme, even more so than Luvox.
Anyways, hope I was able to be of some help. Good luck!
--Michael
Posted by lostsailor on January 23, 2003, at 18:37:01
In reply to Re: serzone and nardil ok??, posted by Ame Sans Vie on January 23, 2003, at 13:18:20
>>Posted by SLS on January 21, 2003, at 12:25:03
Nefazodone is being withdrawn from all European markets. The reason cited is an unacceptably high rate of liver failure, including 26 deaths. No such plans have been announced for the US.
http://www.altapharm.org/college/news/PharmNewsDetails.cfm?ID=3600
- Scott
<<...I remember being treated with Serezone and hating the experience. Doc. had mentioned at the time that we would want to do LF tests. Last year I asked about trying it as an ajunt; I remember his pause, before saying :"the recent lit may be indicating...and I am mot prescrping that until I see 'new" test resluts.." --strange??? thanx for being on the ball, doc
This is the end of the thread.
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