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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by lonesomeloser on January 20, 2003, at 20:42:56
The latest news I have read about a possible
MAOI patch, that may be released as soon as 2003 or 2004, involves the use of the medication, Selegiline, a MAO-B (dopamine) agent rather then Nardil or Parnate which target MAO-A (Serotonin and Epinephrine)the classical antidepressant agent targets.Anyone have any ideas why this is so ?
Posted by River1924 on January 20, 2003, at 20:52:42
In reply to Nardil Patch: When or If ? , posted by lonesomeloser on January 20, 2003, at 20:42:56
Doesn't deprenyl (selegiline) act like a regular MAOI except at low doses? Deprenyl has a "cachet" among life-extension and nootropic people and has been approved for Parkinson's: my guess is that some company is just willing to put the money into a deprenyl patch.
Is there a reason for a patch of Nardil or Parnate? It is in your systems for days anyway.
Posted by lonesomeloser on January 20, 2003, at 21:06:08
In reply to Re: Nardil Patch: When or If ? , posted by River1924 on January 20, 2003, at 20:52:42
> Doesn't deprenyl (selegiline) act like a regular MAOI except at low doses? Deprenyl has a "cachet" among life-extension and nootropic people and has been approved for Parkinson's: my guess is that some company is just willing to put the money into a deprenyl patch.
>
> Is there a reason for a patch of Nardil or Parnate? It is in your systems for days anyway.I was under the impression, by the liturature I have read, that Deprenyl effected the MAO-B dopamine system in low-dose(below 10 mg/day and both MAO-A & MAO-B in doses over 10 mg/day, but I may well be mistaken.
The Patch would bypass the gastric route and thereby allow traditional Nardil or Parnate into the bloodstream and brain, allowing users to consume a more normal diet containing Tyramine, which cannot be allowed with the pill form.I hope that one of the Pharm companies come out with one soon because I sure miss my Avacados :)
Posted by Jumpy on January 20, 2003, at 21:51:06
In reply to Nardil Patch: When or If ? , posted by lonesomeloser on January 20, 2003, at 20:42:56
The patch is for selegiline ... not nardil or parnate. Your correct in that above 10mg, selegiline inhibits both MAOI A and B. With the patch, none of the medication gets bound to the gut MAOIs .... so a lower dosage can be used. The selegiline patch is going to help many many people .... maybe the SSRI companies are blocking it?
J
Posted by Jack Smith on January 21, 2003, at 11:54:20
In reply to Re: Nardil Patch: When or If ? » lonesomeloser, posted by Jumpy on January 20, 2003, at 21:51:06
What company is developing the selegeline patch? Anyway, I have heard of this being in development for years and still no approval and not on the market, probably never will be.
Posted by River1924 on January 21, 2003, at 17:45:21
In reply to Nardil Patch: When or If ? , posted by lonesomeloser on January 20, 2003, at 20:42:56
When I googled "deprenyl" and "patch", an article stated Somerset Pharmaceuticals would like to market a 20mg daily patch under the name EmSam. It was denied by the FDA a few years ago but new studies (one which was published Nov 2002) support its effectiveness and the company will try again.
Posted by Jack Smith on January 21, 2003, at 20:51:51
In reply to Re: Nardil Patch: When or If ? Deprenyl patch, posted by River1924 on January 21, 2003, at 17:45:21
Here's a link to an article from december. I still remain wary that it will be approved anytime soon. The FDA does a good job but perhaps they are too cautious. I mean there are so many things available in Europe that just aren't available here. And things come out quicker in Europe--ssris were around for several years before prozac hit the US.
Posted by River1924 on January 21, 2003, at 21:17:03
In reply to Re: Nardil Patch: When or If ? Deprenyl patch, posted by Jack Smith on January 21, 2003, at 20:51:51
I remain wary, also. Besides, I no longer believe in magic pills or patches. (Or, I try not to get my hopes too high.) [I bought liquid deprenyl and one drop of it daily (1mg) made me increasingly anxious and sweaty as the days went by...so I have $68.00 worth of a $69.00 bottle.] Getting back to the original question in this thread, I wouldn't want a Nardil patch. Nardil (like most meds) puts me into 12 to 16 hour sleeps. I hope it becomes available for those it would help. AIDs and cancer drugs are given fast tracks. If Congress and the FDA experienced chronic mental health probs, I'm sure drugs for my winter depression, suicidal impulses, wasted youth/missed opportunities/social phobia/ sleepiness....etc...I'm sure treatments would be more available. Too bad the nature of mental illness is self-involvement and not political activism. Oh well, River.
Posted by Jack Smith on January 22, 2003, at 11:58:21
In reply to Re: Nardil Patch: When or If ? Deprenyl patch » Jack Smith, posted by River1924 on January 21, 2003, at 21:17:03
How long were you on Nardil? I have heard such good things about it, you are one of the first to say negative things, have you tried parnate?
Posted by ZeeZee on January 22, 2003, at 16:14:07
In reply to Re: Nardil Patch: When or If ?, posted by Jack Smith on January 21, 2003, at 11:54:20
MAOI patch revisited
Posted by ZeeZee on January 19, 2003, at 10:02:11
Antidepressant by Patch May Cut Risky Side Effects
Reuters HealthBy Merritt McKinney
******Monday, December 30, 2002*******
NEW YORK (Reuters Health) - An experimental skin patch may eliminate the need for dietary restrictions in people taking a certain type of antidepressant, according to a recent study.For some people with hard-to-treat depression, antidepressants called monoamine oxidase inhibitors (MAOIs) are the most effective treatment, but the drugs can have dangerous interactions with a long list of foods.
Now, researchers report that a skin patch containing the MAOI selegiline safely and effectively treats symptoms of depression. Because this was the first study to test an MAOI patch, participants avoided certain foods, but researchers believe that the patch will eliminate the need for a special diet.
For up to 20% of people with depressive and anxiety disorders, MAOIs are the most effective therapy, according to study co-author Dr. J. Alexander Bodkin.
"Despite this, only 1% of the antidepressant prescriptions in the US are for MAOIs," Bodkin, who is at McLean Hospital in Boston, Massachusetts, told Reuters Health. According to Bodkin, this is due "in large part" to the concerns that doctors and patients have about the drugs' interactions with certain foods.
MAOIs block enzymes involved in digesting substances called tyramines, which are fermented proteins found in a variety of foods, including cheeses and soy sauce. People taking MAOIs may experience the "cheese reaction"--a rapid rise in blood pressure that occurs if they eat foods containing tyramines.
Avoiding MAOIs "is keeping full recovery away for many, many people who are suffering more than they need to," Bodkin said.
A patch containing an MAOI "offers a very elegant way of avoiding the MAOI interaction," Bodkin said. He explained that the patch, by bypassing the gut, "leaves the enzymes in the gut relatively unaffected, while targeting the medication at the brain, where it is needed."
A patch containing the MAOI selegiline effectively relieved symptoms of depression in a short-term study, Bodkin and co-author Dr. Jay D. Amsterdam, of the University of Pennsylvania in Philadelphia, report in the November issue of the American Journal of Psychiatry.
In the 6-week study, 177 adults with major depressive disorder were randomly assigned to a daily selegiline patch or a placebo patch that did not contain any medication. Patients wearing the selegiline patch experienced significantly greater improvement in symptoms than those on the placebo. In addition, side effects were no more common in the treatment group than in the placebo group, with the exception of irritation at the site of the patch.
Since this was the first clinical trial to study an MAOI patch, participants abided by a diet that restricted tyramines. However, patients were given doses of tyramine to test their response. The dose required to trigger a response was much higher than consumed in a normal diet, so the authors conclude that dietary restrictions will be "unlikely" for an MOAI patch.
******The patch is not yet available, but Bodkin said that, pending the approval of the US Food and Drug Administration, the patch could be on the market within a year.*********
Somerset Pharmaceuticals, Inc., in Tampa, Florida, provided some of the funding for the study.
SOURCE: American Journal of Psychiatry 2002;159:1869-1875.
Posted by River1924 on January 22, 2003, at 17:19:12
In reply to Re: Nardil Patch: When or If ? Deprenyl patch, posted by Jack Smith on January 22, 2003, at 11:58:21
I did not like Nardil because it was too sedating, assisted in weight gain, and I felt depressed on it. Parnate was okay (stimulating and reduced anxiety), most of the restricted food I never ate any way (fava beans?) and it worked wonders for my normal chocolate cravings. I've never found the MAOI's wonder drugs. I would have continued the Parnate but because I have a seasonal aspect to my depression, I have to be able to take a stimulant. Obviously, MAOI's don't allow this.
This is the end of the thread.
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