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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by EarlyWakening on December 26, 2002, at 23:10:32
Aprepitant is the generic name for MK-869.
It's in Phase III trials for depression, but it looks likely to be approved first for chemotherapy-induced nausea and vomiting, potentially by late Summer.Theoretically, once it is approved for that indication, a physician could prescribe it for depression as well.
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FDA Grants Priority Review for EMEND™, Merck's Investigational
Medicine for Prevention of Chemotherapy-Induced
Nausea and Vomiting
UPPER GWYNEDD, Pa., Dec. 6, 2002 - Merck & Co., Inc. announced today that the U.S. Food and Drug Administration has assigned a six-month priority review to the company's New Drug Application (NDA) for EMEND™ (aprepitant), an investigational Substance P neurokinin-1 (NK-1) receptor antagonist studied in combination with other anti-emetic agents for the prevention of chemotherapy-induced nausea and vomiting (CINV).
Merck's application for EMEND includes results from seven safety and efficacy studies that evaluated this once-daily, oral medicine in combination with other anti-emetic drugs in patients with acute (0 to 24 hours) and delayed (2 to 5 days) nausea and vomiting associated with single and repeated courses of highly emetogenic chemotherapy, including cisplatin.Merck researchers have been studying investigational agents that block the binding of Substance P to NK-1 receptors in the brain and gastrointestinal tract to determine if these agents may inhibit the nausea and vomiting frequently induced by anti-cancer medicines.
Posted by utopizen on December 28, 2002, at 17:49:01
In reply to Substance P Antagonist Being Reviewed by FDA, posted by EarlyWakening on December 26, 2002, at 23:10:32
I wonder if this is related to Marinol, which I think is like $40/pill (and as a result, prohibitive) also, Marinol isn't considered so cool of a drug.. heard it's not just "boring" but even annoying in its feel.
I think the $40 cost may have something to do with the bizarre security precautions it takes en route to distribution, a la DEA requirements for it... not that it has any abuse potential, but perhaps its precursors may.
This is the end of the thread.
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