Psycho-Babble Medication Thread 133306

Shown: posts 1 to 2 of 2. This is the beginning of the thread.

 

Substance P Antagonist Being Reviewed by FDA

Posted by EarlyWakening on December 26, 2002, at 23:10:32

Aprepitant is the generic name for MK-869.
It's in Phase III trials for depression, but it looks likely to be approved first for chemotherapy-induced nausea and vomiting, potentially by late Summer.

Theoretically, once it is approved for that indication, a physician could prescribe it for depression as well.

----------------------
FDA Grants Priority Review for EMENDâ„¢, Merck's Investigational
Medicine for Prevention of Chemotherapy-Induced
Nausea and Vomiting


UPPER GWYNEDD, Pa., Dec. 6, 2002 - Merck & Co., Inc. announced today that the U.S. Food and Drug Administration has assigned a six-month priority review to the company's New Drug Application (NDA) for EMENDâ„¢ (aprepitant), an investigational Substance P neurokinin-1 (NK-1) receptor antagonist studied in combination with other anti-emetic agents for the prevention of chemotherapy-induced nausea and vomiting (CINV).


Merck's application for EMEND includes results from seven safety and efficacy studies that evaluated this once-daily, oral medicine in combination with other anti-emetic drugs in patients with acute (0 to 24 hours) and delayed (2 to 5 days) nausea and vomiting associated with single and repeated courses of highly emetogenic chemotherapy, including cisplatin.

Merck researchers have been studying investigational agents that block the binding of Substance P to NK-1 receptors in the brain and gastrointestinal tract to determine if these agents may inhibit the nausea and vomiting frequently induced by anti-cancer medicines.


 

Re: Substance P Antagonist Being Reviewed by FDA

Posted by utopizen on December 28, 2002, at 17:49:01

In reply to Substance P Antagonist Being Reviewed by FDA, posted by EarlyWakening on December 26, 2002, at 23:10:32

I wonder if this is related to Marinol, which I think is like $40/pill (and as a result, prohibitive) also, Marinol isn't considered so cool of a drug.. heard it's not just "boring" but even annoying in its feel.

I think the $40 cost may have something to do with the bizarre security precautions it takes en route to distribution, a la DEA requirements for it... not that it has any abuse potential, but perhaps its precursors may.


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.