![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by JackD on December 25, 2002, at 16:06:08
After starting Lamictal 300mg over the summer, i suddenly noticed an enormous difference in how my Klonopin would feel. It seemed much more powerful, and at first made me almost euphoric. Unfortunately this only lasted a week or so, or at least any euphoric effects. I later stopped the Klonopin for a while, and started again in September. The same thing happened: a week or two of euphoria and giddiness after each dose, and lasting most of the day. Now, do these two drugs get metabolized by the same enzymes or something? How can there be a synergy between Klonopin and Lamictal? I would LOVE some insight on this perplexing problem.
Posted by jimmygold70 on December 25, 2002, at 18:05:38
In reply to Lamictal + Klonopin... Any help from you medheds?, posted by JackD on December 25, 2002, at 16:06:08
Very simple. GABA and glutamate are the main neurotransmitters in the brain. GABA is inhibitory and glutamate is excitatory - negating each other. LAmictal lowers glutamate levels, and Klonopin raises GABA levels, and there you got - a SYNERGY!
Jimmy
Posted by JackD on December 28, 2002, at 1:02:21
In reply to Re: Lamictal + Klonopin... Any help from you medheds? » JackD, posted by jimmygold70 on December 25, 2002, at 18:05:38
Are high levels of GABA associated with pleasure or euphoric feelings? I would think more GABA would just depress the brain, as it is inhibitory like you said. Thanks for the help.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.