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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Aadika on December 17, 2002, at 15:23:33
Hopefully someone can answer this question for me soon, but if not, I suppose I'll just have to find out for myself.
Oh, one other thing-- I could have sworn I read somewhere that naproxen (Aleve / Naprosyn) potentiates Klonopin. Anyone know if this is true? I've looked all over the appallingly incomplete p450 enzyme sites I've come across and have found no mention of either of these two interactions, but based entirely on anecdotal evidence, I wonder if this is true...
Thanks in advance,
~ Aadika
Posted by Larry Hoover on December 17, 2002, at 16:29:56
In reply to Does ibuprofen (Advil) really interact with Xanax?, posted by Aadika on December 17, 2002, at 15:23:33
> Hopefully someone can answer this question for me soon, but if not, I suppose I'll just have to find out for myself.
>
> Oh, one other thing-- I could have sworn I read somewhere that naproxen (Aleve / Naprosyn) potentiates Klonopin. Anyone know if this is true? I've looked all over the appallingly incomplete p450 enzyme sites I've come across and have found no mention of either of these two interactions, but based entirely on anecdotal evidence, I wonder if this is true...
>
> Thanks in advance,
>
> ~ AadikaThe tables I have studied show that ibuprofen and naproxen are both substracts of CYP2C9, whereas both alprazolam (Xanax) and clonazepam (Klonopin) are substrates of CYP3A4. There should be no interaction of any kind between either of naproxen and ibuprofen with either of Xanax or Klonopin. Grapefruit juice inhibits 3A4, as does fluvoxamine (Luvox) and nefazedone (Serzone). The latter is a profound inhibitor of 3A4.
Posted by Larry Hoover on December 17, 2002, at 16:37:18
In reply to Does ibuprofen (Advil) really interact with Xanax?, posted by Aadika on December 17, 2002, at 15:23:33
Here's a real easy-to-use site:
Posted by Aadika on December 17, 2002, at 16:39:50
In reply to Re: Does ibuprofen (Advil) really interact with Xanax? » Aadika, posted by Larry Hoover on December 17, 2002, at 16:29:56
Thanks a lot-- I knew about the 3A4 interactions, but glad to hear that there are no worries regarding the possible interactions I inquired about. In fact, the only reason I asked was because I believe I've read about naproxen having a potentiating effect on clonazepam (which I mentioned in my last post), and I've read some threads on this board that were related to the interaction between alprazolam and ibuprofen.
~ Aadika
Posted by Aadika on December 17, 2002, at 17:36:09
In reply to Re: Does ibuprofen (Advil) really interact with Xanax?, posted by Larry Hoover on December 17, 2002, at 16:37:18
Thanks a bunch for the link-- I've got it bookmarked. Though I swear there must be some interaction between ibuprofen and Xanax... I took 2mg alprazolam along with two Advil and it most certainly feels as if I'd taken twice that amount. Ah well, guess I'll research into this further, but your help is greatly appreciated. :-)
~ Aadika
Posted by Larry Hoover on December 19, 2002, at 11:14:43
In reply to Re: Does ibuprofen (Advil) really interact with Xanax? » Larry Hoover, posted by Aadika on December 17, 2002, at 16:39:50
> Thanks a lot-- I knew about the 3A4 interactions, but glad to hear that there are no worries regarding the possible interactions I inquired about. In fact, the only reason I asked was because I believe I've read about naproxen having a potentiating effect on clonazepam (which I mentioned in my last post), and I've read some threads on this board that were related to the interaction between alprazolam and ibuprofen.
>Perhaps there's a need to look at terminology a little bit. Interaction is usually used in the context of one drug changing the kinetics of another. That is to say, the normal metabolic processing of a drug is affected by the presence of another. There are other ways that drug combinations act, however. They might be called additive effects, or synergistic effects, but they are not, strictly speaking, interactions. There is an additive effect of ibuprofen and alprazolam. The following article demonstrates that. You'll need Adobe Acrobat to view it.
http://www.biomed.cas.cz/physiolres/2002/issue2/pdf/dolezal.pdf
> ~ Aadika
This is the end of the thread.
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