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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by ben on February 21, 2001, at 4:45:51
Hi
Does anyone have experiences with Flupenthixol or (and) Melitracene ? I am taking Deanxit in addition to Celexa as an augmentation strategy (unipolar depression). Flupenthixol should have an antidepressant and mood-stabilizing effect with an early onset of action. Melitracene is a tricyclic AD from the imipramine-type. Any ideas or suggestions ?
Posted by JahL on February 21, 2001, at 10:17:22
In reply to Celexa and Deanxit (Melitracene + Flupenthixol), posted by ben on February 21, 2001, at 4:45:51
> Hi
> Does anyone have experiences with Flupenthixol or (and) Melitracene ? I am taking Deanxit in addition to Celexa as an augmentation strategy (unipolar depression). Flupenthixol should have an antidepressant and mood-stabilizing effect with an early onset of action.Hi Ben.
Theoretically you are right about Flupenthixol. In a no. of double-blind studies it was found to be of 'equivalent' efficacy to ami/nortriptylene, @ low doses.
However few studies have been done for severe depression (true test of AD) & most of the benefits are seen in mixed anxiety-depressive states.
The theory behind this is that the traditional neuroleptics reduce depression scores chiefly through reducing anxiety (a big component of the HRSD). A less anxious person will likely feel better. This has been my experience with Sulpiride.
My pdoc refused to prescribe Flupenthixol a while back due to unacceptable potential risk for developing Tardive Dyskinesia.
The newer APs supposedly carry much less risk for this, & through actions on receptors other than Dopamine, are better all-round AD augmentors. Recent studies have noted synergy btwn SSRIs (ie Celexa) & the likes of Risperdal & Zyprexa.
Jah.
Posted by ben on February 21, 2001, at 10:56:19
In reply to Re: Celexa and Flupenthixol » ben, posted by JahL on February 21, 2001, at 10:17:22
> > Hi
> > Does anyone have experiences with Flupenthixol or (and) Melitracene ? I am taking Deanxit in addition to Celexa as an augmentation strategy (unipolar depression). Flupenthixol should have an antidepressant and mood-stabilizing effect with an early onset of action.
>
> Hi Ben.
>
> Theoretically you are right about Flupenthixol. In a no. of double-blind studies it was found to be of 'equivalent' efficacy to ami/nortriptylene, @ low doses.
>
> However few studies have been done for severe depression (true test of AD) & most of the benefits are seen in mixed anxiety-depressive states.
>
> The theory behind this is that the traditional neuroleptics reduce depression scores chiefly through reducing anxiety (a big component of the HRSD). A less anxious person will likely feel better. This has been my experience with Sulpiride.
>
> My pdoc refused to prescribe Flupenthixol a while back due to unacceptable potential risk for developing Tardive Dyskinesia.
>
> The newer APs supposedly carry much less risk for this, & through actions on receptors other than Dopamine, are better all-round AD augmentors. Recent studies have noted synergy btwn SSRIs (ie Celexa) & the likes of Risperdal & Zyprexa.
>
> Jah.Many thanks Jahl
How could the effect of Risperidone in addition to SSRIS (like Citalopram) be
explained ? Is it the serotonin or the dopamine mechanism or both ? What do you think about
amisulpride instead of risperidone, i read a lot
of good things about amisulpride. I think Zyprexa wont be good for me because of the sedation and weight gain. I need a mood booster for my melancholic depression.
, not a sedating or activating drug. What could be a good option to celexa if de Deanxit fails ?
I tried Lithium (stopped about terrible nausea),
Remeron (too sedating and headaches), Effexor and Surmontil (Trimipramine).
without good success.ben
Posted by JahL on February 21, 2001, at 13:48:55
In reply to Re: Celexa and Flupenthixol, posted by ben on February 21, 2001, at 10:56:19
> > Many thanks Jahl
> > How could the effect of Risperidone in addition to SSRIS (like Citalopram) be explained ? Is it the serotonin or the dopamine mechanism or both ?I'm no pharmacologist but I think Risperdone et al are (weak?) 5-HT2 antagonists, which are thought to enhance the action of serotonin. I have seen a couple of very impressive (altho' small) studies documenting this synergy.
> >What do you think about amisulpride instead of risperidone, i read a lot of good things about amisulpride.
I would try Risperdone first, given you are on therapeutic levels of an SSRI. Successful augmentation will make itself apparent very quickly (1 day-1 week).
Amisulpiride seems to be helpful for dysthymia, social phobia but is not generally used to 'augment'.
> > I think Zyprexa wont be good for me because of the sedation and weight gain.
Don't write it off (could be useful adjunct).
> > I need a mood booster for my melancholic depression.
< You & me both! >
> > , not a sedating or activating drug. What could be a good option to celexa if de Deanxit fails ?
(Dean-what?)
I'll open this one to the others out there.
Jah.
Posted by freedom2001 on October 11, 2002, at 2:47:31
In reply to Celexa and Deanxit (Melitracene + Flupenthixol), posted by ben on February 21, 2001, at 4:45:51
> Hi
> Does anyone have experiences with Flupenthixol or (and) Melitracene ? I am taking Deanxit in addition to Celexa as an augmentation strategy (unipolar depression). Flupenthixol should have an antidepressant and mood-stabilizing effect with an early onset of action. Melitracene is a tricyclic AD from the imipramine-type. Any ideas or suggestions ?
May I know how does Deanxit work? Which neuro system does it work on? Is it similar to risperidone? Is it helpful with OCD? I'm taking it in addition to Prozac for OCD.
Posted by petters on October 12, 2002, at 4:30:02
In reply to Re: Celexa and Deanxit (Melitracene + Flupenthixol) » ben, posted by freedom2001 on October 11, 2002, at 2:47:31
Hi.
I hope you don´t mind me asking, how high dosage flupenthixol you take ?Result ?
Thanks in advance.
......//// Petters
Posted by freedom2001 on October 12, 2002, at 10:17:31
In reply to Re: Celexa and Deanxit (Melitracene + Flupenthixol), posted by petters on October 12, 2002, at 4:30:02
> Hi.
> I hope you don´t mind me asking, how high dosage flupenthixol you take ?0.5mg x 2, 10 mg x 2
I'm not sure which compound is which mg....
>
> Result ?
>
> Thanks in advance.
>
> ......//// Petters
This is the end of the thread.
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