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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Squiggles on August 7, 2002, at 15:59:15
Sounds to me like the wisest choice
would be to try a lithium increase, if not
by 300, maybe by 250. It's the blood level
that is important NOT the dose in each individual.As for conversion of Lamactal to Lithium,
since one is a GABBA drug and the other
an inositol drug - yeah apples and oranges,
unless you compare them phenomenologically.If you feel better with in increase in Lamactal
at a certain dose, and keep the lithium at
the present one, I suppose that would be the answer.It is a pain in the neck to have to play around
with drugs but sometimes you hit the right key.good luck;
Squiggles
Posted by Maximus on August 7, 2002, at 20:46:50
In reply to Apples and oranges, posted by Squiggles on August 7, 2002, at 15:59:15
> As for conversion of Lamactal to Lithium,
> since one is a GABBA drug and the other
> an inositol drug - yeah apples and oranges,
> unless you compare them phenomenologically.I'm sorry but i don't know what you are talking about. However, both molecules have an extremely complexed mechanism of action. (Shortly), Lamictal is an inhibiter of the "glutamate" release. Even if Lithium has a slight enhancing action on GABA, its main action is on "glutamate" too. Both Lamictal and Lithium are associated with a reduction of NMDA receptor-mediated calcium-sodium influx.
They have both their weakness and their forces. Taking the two is taking the best of the both worlds (even if they aren't totally different), as you can see.
http://www.apa.org/monitor/sep98/lith.html
http://www.pslgroup.com/dg/8CF9A.htm
http://www.sciencenews.org/sn_arc98/3_14_98/fob3.htm
http://www.mddaboston.org/lect032200.htmlhttp://www.glaxowellcome.com.sa/Products/CNS.htm
http://www.nmhct.nhs.uk/pharmacy/epi2.htmAnd so on...
Hope that helps!
Posted by Squiggles on August 7, 2002, at 21:14:26
In reply to Re: Correction... » Squiggles, posted by Maximus on August 7, 2002, at 20:46:50
Thanks for the correction and information;
excuse me for being vague - i dumped the Lamactal
in the GABBA category, thinking that Lithium
only has an effect on inositol. I am a general
reader however and you seem to be a doctor.And it shows - thanks again.
Squiggles
Posted by Maximus on August 7, 2002, at 21:31:52
In reply to Re: Correction... » Maximus, posted by Squiggles on August 7, 2002, at 21:14:26
> in the GABBA category, thinking that Lithium
> only has an effect on inositol. I am a general
> reader however and you seem to be a doctor.No problem. However i'm not a doctor, but my wife is. Even if i don't get any treatment from her, she answers very well to many of my interrogations. I love to read too. My pdoc takes care of my mental health.
Bye!
This is the end of the thread.
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